ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

June 15, 2022

Primary Completion Date

October 31, 2026

Study Completion Date

April 30, 2027

Conditions
Advanced/Metastatic Solid Tumors
Interventions
DRUG

ADG126

ADG126 is an anti-CTLA-4 fully human monoclonal antibody that specifically binds to human CTLA-4.

DRUG

Pembrolizumab (KEYTRUDA®)

Pembrolizumab (KEYTRUDA®) is a PD-1 receptor-blocking antibody (a humanized IgG4 monoclonal antibody).

DRUG

Standard of Care (Trifluridine/Tipiracil-Bevacizumab)

The standard of care therapies will include Trifluridine/Tipiracil-Bevacizumab, approved for treating metastatic colorectal cancer (CRC)and various solid tumors.

DRUG

Standard of care (Fruquintinib)

The standard of care therapy, Fruquintinib, is approved for treating metastatic colorectal cancer (CRC) and various solid tumors.

Trial Locations (17)

3722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

13496

RECRUITING

CHA Bundang Medical Center, CHA university, Seongnam

16247

RECRUITING

The Catholic University of Korea Street. Vincent Hospital, Suwon

28644

RECRUITING

Chungbuk National University Hospital, Cheongju-si

34232

RECRUITING

Florida cancer specialist/Sarah Cannon Research Institute, Sarasota

41931

RECRUITING

Keimyung University Dongsan Hospital, Daegu

49201

RECRUITING

Dong -A University Hospital, Seogu

85251

RECRUITING

Honor Health Research Institute, Scottsdale

91010

RECRUITING

City of Hope National Medical Center, Duarte

Unknown

RECRUITING

Fujian Cancer Hospital, Fuzhou

RECRUITING

SunYat-Sen University Cancer Center, Guangzhou

RECRUITING

Hong Kong Humanity & Health Clinical Trial Center, Hong Kong

RECRUITING

Prince of Wales Hospital, Hong Kong

06351

RECRUITING

Samsung Medical Center, Seoul

03080

RECRUITING

Seoul National University Hospital, Seoul

03081

RECRUITING

KangBuk Samsung Hospital, Seoul

05505

RECRUITING

Asan Medical Center, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Adagene Inc

INDUSTRY

NCT05405595 - ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors | Biotech Hunter | Biotech Hunter