Research Study Investigating How Well NDec Works in People With Sickle Cell Disease

PHASE2CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

July 7, 2022

Primary Completion Date

December 10, 2024

Study Completion Date

July 24, 2025

Conditions
Sickle Cell Disease
Interventions
DRUG

NDec - oral decitabine-tetrahydrouridine

Participants will get capsules (oral administration) to take once or twice weekly. The number of capsules will be based on their body weight

DRUG

HU - Hydroxyurea

Participants will get capsules daily (oral administration) according to local labelling

DRUG

Placebo

Participants will get capsules (oral administration) to take once or twice weekly. The number of capsules will be based on their body weight

Trial Locations (48)

123

Sultan Qaboos University Hospital, Muscat

2193

Charlotte Maxeke Johannesburg Academic Hospital, Parktown, Johannesburg

10029

Mount Sinai School of Medicine, New York

11527

Aghia Sophia Childrens' Hospital, Goudi

19134

St Christopher Hosp for Child, Philadelphia

20122

Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico, Milan

26504

Gen Univ Hospital of Patras, Thalassemia/Hemoglobinopathies, Pátrai

28046

Hospital Universitario La Paz, Madrid

33110

Mersin University Medical Faculty Hospital, Hematology, Mersin

35128

Azienda Ospedale Universita Padova, Padua

37134

Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma, Verona

Policlinico GB Rossi, Verona

38043

Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-3, Grenoble

39110

Mississippi Center Advanced Medicine, Madison

41221

General Hospital Of Larissa Koutlibaneio And Triantafylleio, Larissa

60612

University Of Illinois at Chicago, Chicago

69437

Hospices Civils de Lyon-Hopital Edouard Herriot, Lyon

70014

NRS Medical College & Hospital, Kolkata

73104

University of Oklahoma Health Sciences Center_Oklahoma City, Oklahoma City

77030

Univ Texas HSC-Houston, Houston

80045

Clinical and Transl Res Center, Aurora

89135

Cure 4 the Kids Foundation, Las Vegas

94609

UCSF Oakland Benioff Children's Hospital, Oakland

390001

SSG Hospital, Baroda, Vadodara

390006

SSG Hospital, Baroda, Vadodara

395002

Nirmal Hospital Pvt. Ltd., Surat

395009

BAPS Pramukh Swami Hospital, Surat

440001

KIMS - Kingsway Hospital, Nagpur

440003

Government Medical College and Hospital, Nagpur

Government Medical College and Super Speciality Hospital, Nagpur, Nagpur

560002

Victoria Hospital (Bangalore Medical College and Research Institute), Bangalore

632517

Christian Medical College Hospital, Vellore, Ranipet

673008

Government Medical College, Kozhikode, Kozhikode

700014

NRS Medical College & Hospital, Kolkata

751003

IMS and SUM Hospital, Bhubaneswar

753007

S.C.B. Medical College, Cuttack

90502-2004

Harbor-UCLA Medical Center, Torrance

ON N6A 5W9

LHSC - Victoria Hospital, London

M5G 2C4

Toronto General Hospital, Liver Clinic, Toronto

M5G2C4

Toronto General Hospital, Liver Clinic, Toronto

H4A 3J1

McGill University Health Centre, Montreal

01130

Acibadem Adana Hastanesi, Adana

Cukurova Universitesi, Adana

06230

Hacettepe University Hematology, Ankara

CF14 4XW

University Hospital of Wales, Cardiff

NW10 7NS

Central Middlesex Hospital, London

SE1 9RT

Guy's Hosptial, London

SE5 9RS

Kings College Hospital, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY