A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight

PHASE3CompletedINTERVENTIONAL
Enrollment

1,200

Participants

Timeline

Start Date

February 1, 2023

Primary Completion Date

January 28, 2025

Study Completion Date

February 3, 2025

Conditions
OverweightObesityType 2 Diabetes Mellitus
Interventions
DRUG

Cagrilintide

Cagrilintide administered subcutaneously (s.c., under the skin) once-weekly

DRUG

Semaglutide

Semaglutide administered subcutaneously (s.c., under the skin) once-weekly

DRUG

Placebo cagrilintide

Placebo cagrilintide administered subcutaneously (s.c., under the skin) once-weekly

DRUG

Placebo semaglutide

Placebo semaglutide administered subcutaneously (s.c., under the skin) once-weekly

Trial Locations (173)

1030

Klinik Landstraße, Vienna

1033

Clinexpert Egészségügyi Szolgáltató és Kereskedelmi Kft., Budapest

1042

Szőcs Depot Egészségügyi Szolgáltató Kft., Budapest

1090

Universitätsklinikum AKH Wien, Vienna

1106

Bajcsy-Zsilinszky Kórház, Budapest

1190

Imed 19- privat, Vienna

2900

Komáromi Selye János Kórház, Komárom

Selye János Kórház és Rendelőintézet, Komárom

4032

Debreceni Egyetem Belgyógyászati Klinika, Debrecen

5000

Hetényi Géza Kórház, Szolnok

5004

Hetényi Géza Kórház, Szolnok

6725

Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ, Szeged

8036

Universitätsklinik für Innere Medizin Graz, Graz

8511

Fließer-Görzer [Ordination], Saint Stefan

10330

King Chulalongkorn Memorial Hospital_Bangkok, Bangkok

King Chulalongkorn Memorial Hospital_Endocrinology, Bangkok

10400

Ramathibodi Hospital, Bangkok

Rajavithi Hospital_Diabetes and Endocrinology, Bangkok

Rajavithi Hospital, Bangkok

Ramathibodi Hospital, Bangkok

10700

Siriraj Hospital_Bangkoknoi, Bangkok, Bangkoknoi, Bangkok

SI-Dvs of Endocrinology, Bangkok

12120

Thammasat Hospital, Pathum Thani

12203

AMC Community Endocrinology, Albany

14224

Southgate Medical Group, LLP, West Seneca

14787

Great Lakes Medical Research, Westfield

22607

Wendisch/Dahl Hamburg (DZHW), Hamburg

23294

National Clin Res Inc., Richmond

27408

PharmQuest Life Sciences LLC, Greensboro

30076

Endo Res Solutions Inc, Roswell

32003

Northeast Research Institute, Fleming Island

32040

Hospital Seri Manjung, Seri Manjung

32216

Jacksonville Ctr For Clin Res, Jacksonville

32765

Oviedo Medical Research, LLC, Oviedo

32804

AdventHealth Diab Inst, Orlando

32825

Florida Institute for Clinical Research, LLC, Orlando

33765

Clinical Res Of W Florida Inc, Clearwater

34470

Renstar Medical Research, Ocala

37660

Holston Medical Group, Kingsport

40002

Srinagarind Hospital, Khon Kaen

40213

L-MARC Research Center, Louisville

45136

InnoDiab Forschung GmbH, Essen

47000

University Technology MARA (UiTM) - Sg Buloh, Sungai Buloh

48145

Institut für Diabetesforschung GmbH Münster - Dr. med. Rose, Münster

49620

Northern Pines Hlth Ctr, PC, Buckley

50266

Iowa Diab & Endo Res Center, West Des Moines

55416

International Diabetes Center, Minneapolis

56000

Hospital Universiti Kebangsaan Malaysia, Cheras

59701

Mercury Str Med Grp, PLLC, Butte

60607

Cedar-Crosse Research Center, Chicago

62250

Hospital Putrajaya, Putrajaya

63303

StudyMetrix Research LLC, City of Saint Peters

66386

Zentrum für klinische Studien Alexander Segner, Saint Ingbert-Oberwürzbach

68000

Hospital Ampang, Ampang, Selangor

70300

Hospital Tuanku Jaafar, Seremban

70378

MZM Praxis Drs. Erlinger, Stuttgart

70808

Pennington Biom Res Ctr, Baton Rouge

75230

Velocity Clinical Res-Dallas, Dallas

75231

North Texas Endocrine Center, Dallas

75400

Hospital Melaka, Malacca

75605

DCOL Ctr for Clin Res, Longview

77079

PlanIt Research, PLLC, Houston

78231

Consano Clinical Research, LLC, Shavano Park

78731

Texas Diab & Endo, P.A., Austin

78749

Texas Diab & Endo, P.A., Austin

79106

Amarillo Med Spec LLP, Amarillo

80401

New West Physicians,Inc., Golden

84790

Chrysalis Clinical Research, St. George

88239

Zentrum für klinische Studien Allgäu Oberschwaben, Wangen

90017

Velocity Clin Res Los Angeles, Los Angeles

90057

Velocity Clin Res Wstlke, Los Angeles

92025

Headlands Research California, LLC, Escondido

92262

Desert Oasis Hlthcr Med Group, Palm Springs

92648

Diabetes/Lipid Mgmt & Res Ctr, Huntington Beach

92835

Providence Medical Foundation, Fullerton

St. Jos Heritage Hlthcr_Fllrtn, Fullerton

93586

Sarawak General Hospital, Kuching

94520

John Muir Physicians Network, Concord

94598

Diablo Clinical Research, Inc., Walnut Creek

95648

Clinical Trials Research, Lincoln

96814

East West Med Res Inst, Honolulu

97980

Diabetespraxis Mergentheim, Bad Mergentheim

98000

Hospital Miri, Miri

98502

Capital Clin Res Ctr,LLC, Olympia

110001

Lady Hardinge Medical College, New Delhi

110029

All India Institute of Medical Sciences_Delhi, Ansārinagar

160012

Post Graduate Institute of Medical Education & Research_Chandigarh, Chandigarh

302004

J K Lon Hospital, SMS Medical College & Attached Hospitals, Jaipur

SMS Medical College & Hospital, Jaipur

380006

HCG Hospitals, Ahmedabad

400008

BYL Nair Hospital and T N Medical College Department of endo, Mumbai

400012

Seth GS medical college and KEM Hospital, Mumbai

411013

Noble Hospitals Pvt Ltd., Pune

416008

Excel Endocrine Centre, Kolhāpur

440010

Sunil's Diabetes Care n' Research Centre Pvt Ltd, Nagpur

Sunil's Diabetes Care n' Research Centre Pvt Ltd, Nagpur

500004

Gleneagles Hospitals, Hyderabad

560054

Ramaiah Memorial Hospital, Bangalore

600006

Apollo Research & Innovation (ARI), Chennai

600086

Madras Diabetes Research Foundation, Chennai

673008

Calicut Medical College, Kozhikode

695033

Indian Institute of Diabetes, Thiruvnanthapuram

700054

Apollo Multispeciality Hospital, Kolkata, Kolkata

Apollo Multispeciality Hospitals Limited, Kolkata

66606-2806

Cotton-Oneill Diabetes and End, Topeka

29681-1538

Hillcrest Clinical Research, Simpsonville

75390-9302

UT Southwestern Med Cntr, Dallas

22601-3834

Selma Medical Associates, Winchester

T2H 2G4

LMC Clin Res Inc. Calgary, Calgary

T2V 4J2

C-endo Diab Endo Clin Calgery, Calgary

V8V 4A1

Dr. M.B. Jones Inc, Victoria

A1N 1W7

Commonwealth Medical Clinic, Mount Pearl

L6S 0C6

Dr. Harpreet Bajaj, Brampton

M9R 4E1

Centricity Research Etobicoke, Etobicoke

L8L 5G8

Wharton Med Clin Trials, Hamilton

K2J 0V2

LMC Research Inc. Ottawa, Nepean

M6G 1M2

Diabetes Heart Research Centre, Toronto

H4N 2W2

Centre Medical Acadie, Montreal

H4T 1Z9

LMC Clin Rsrch Inc. (Montreal), Saint-Laurent

04910

Zentrum fuer klinische Studien Suedbrandenburg GmbH, Elsterwerda

04107

AmBeNet GmbH, Leipzig

H91 YR71

CRF - Galway, Galway

CRF HRB - Galway, Galway

D04 T6F4

Clinical Research Centre, St. Vincent's University Hospital,, Dublin

D07 XAO9

Mater Miscericordiae Hospital, Dublin

D08 A978

St James's CRF, Dublin

D15 X40D

Connolly Hospital_Blanchardstown_Diabetes Day Centre, Dublin

DUBLIN 15

Connolly Hospital, Dublin

DUBLIN 7

Mater Miscericordiae Hospital, Dublin

468-0009

TOSAKI Clinic for Diabetes and Endocrinology_Diabetes and Endocrinology, Aichi

261-0004

Tokuyama clinic_Diabetic internal medicine, Chiba

311-0113

Naka Kinen Clinic_Internal medicine, Ibaraki

530-0001

Osaka Nishiumeda Clinic_Diabetes Internal Medicine, Osaka

565-0871

Osaka University Hospital, Osaka

569-1045

Takatsuki Red Cross Hospital, Osaka

85-796

Gierach-Med, Bygdoszcz

Gierach-Med, Bygdoszcz

30-721

Linden sp. z o.o. sp. k., Krakow

Linden sp. z o.o. sp. k., Krakow

59-220

"Beata Mikłaszewicz & Dariusz Dąbrowski CARDIAMED s.j.", Legnica

20-333

Terpa Sp. z o.o. Sp. k., Lublin

Terpa Sp. z o.o. Sp. k., Lublin

00-416

Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orłowskiego Centrum Medycznego Kształcenia Podyplomowego, Warsaw

02-798

Medical Concierge Centrum Medyczne, Warsaw

02-117

Instytut Diabetologii Sp. z o.o., Warsaw

Instytut Diabetologii Sp. z o.o., Warsaw

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

15-281

Gabinet Leczenia Otylosci i Chorob Dietozaleznych, Bialystok

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

40-772

Centrum Medyczne Salvia, Katowice

82-300

Klinika Bellamed, Elblag

60-589

Centrum Zdrowia Metabolicznego, Poznan

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

97-300

Trialmed CRS, Piotrkow Trybunalski

00716

Ponce Med School Found Inc, Ponce

HG2 7SX

Harrogate District Hospital, Harrogate

KT15 2BH

Crouch Oak Family Practice, Addlestone

BT42 2RL

Antrim Area Hospital, Antrim

FY3 7EN

Layton Medical Centre, Blackpool

BA15 1DQ

The Health Centre, Bradford-on-Avon

BS10 5NB

Southmead Hospital, Bristol

SN14 6GT

Hathaway Medical Centre, Chippenham

TW5 9ER

HMC Health Heston, Hounslow

LE5 4PW

Leicester General Hospital, Leicester

CW5 5NX

Kiltearn Medical Centre, Nantwich

S65 1DA

Clifton Medical Centre, Rotherham

CW11 1EQ

Ashfields Primary Care Centre, Sandbach

CB7 5JD

The Staploe Medical Centre, Soham

SA2 8PP

Joint Clinical Research Facility - Swansea, Swansea

TA1 5DA

Musgrove Park Hospital, Taunton

TR1 3LJ

Royal Cornwall Hospital (Treliske), Truro

NN8 4RW

Albany House Medical Centre, Wellingborough

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY