550
Participants
Start Date
February 4, 2021
Primary Completion Date
September 30, 2027
Study Completion Date
September 30, 2027
ECMO support
ECMO prescribed by treating physicians for respiratory support in the setting of PARDS.
PROSpect protocolized therapies
"PROSpect is testing the impact of supine/prone positioning and conventional mechanical ventilation (CMV)/high-frequency oscillatory ventilation (HFOV) on clinical outcomes in 1,000 children with severe PARDS. PROSpect manages severe PARDS subjects using a protocol that reserves ECMO for protocol failure.~The CMV group targets an exhaled tidal volume of 5-7mL/kg of ideal body weight and a peak inspiratory pressure \<28 cm of H2O. The positive end expiratory pressure (PEEP) and FiO2 are titrated by a PEEP-FiO2 titration grid. The HFOV group titrates the mean airway pressure to target a FiO2 \< 0.5 and a goal hemoglobin oxygen saturation of 88-92%. The frequency is titrated between 8-12 Hz and amplitude from 60-90 to achieve a goal pH of 7.15-7.30. Ventilation protocols are implemented until 28 days or extubation. Children randomized to the prone positioning will remain prone for at least 16 consecutive hours per day. Children randomized to supine positioning group remain supine."
RECRUITING
Starship Children's Hospital, Grafton
RECRUITING
Hassenfeld Children's Hospital at NYU Langone, New York
RECRUITING
NewYork-Presbyterian Morgan Stanley Children's Hospital, New York
RECRUITING
NewYork-Presbyterian Komansky Children's Hospital, New York
RECRUITING
Cohen Children's Medical Center, Queens
RECRUITING
John R. Oishei Children's Hospital, Buffalo
RECRUITING
UPMC Children's Hospital of Pittsburgh, Pittsburgh
RECRUITING
Istituto Giannina Gaslini, Genoa
RECRUITING
Penn State Health Children's Hospital, Hershey
RECRUITING
ECMO Centrum Karolinska, Stockholm
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Nemours Children's Hospital, Delaware, Wilmington
WITHDRAWN
University of Maryland Children's Hospital, Baltimore
RECRUITING
Johns Hopkins Children's Center, Baltimore
RECRUITING
Inova L.J. Murphy Children's Hospital, Falls Church
RECRUITING
UVA Children's Hospital, Charlottesville
WITHDRAWN
Children's Hospital of Richmond at VCU, Richmond
RECRUITING
N.C. Children's Hospital, Chapel Hill
RECRUITING
Duke Children's Hospital & Health Center, Durham
RECRUITING
Hospital Gregorio Maranon, Madrid
RECRUITING
MUSC Shawn Jenkins Children's Hospital, Charleston
RECRUITING
Children's Healthcare of Atlanta, Atlanta
RECRUITING
UF Health Shands Children's Hospital, Gainesville
RECRUITING
Orlando Health Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Florida, Orlando
WITHDRAWN
Nicklaus Children's Hospital, Miami
RECRUITING
Children's of Alabama, Birmingham
RECRUITING
Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville
RECRUITING
Le Bonheur Children's Hospital, Memphis
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Cleveland Clinic Children's Hospital, Cleveland
RECRUITING
Akron Children's Hospital, Akron
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
University of Michigan - Mott Children's Hospital, Ann Arbor
RECRUITING
Children's Hospital of Michigan, Detroit
RECRUITING
Helen DeVos Children's Hospital, Grand Rapids
RECRUITING
University of Iowa Health Care Stead Family Children's Hospital, Iowa City
RECRUITING
Children's Wisconsin, Milwaukee
RECRUITING
UW Health American Family Children's Hospital, Madison
RECRUITING
Children's Minnesota Hospital, Minneapolis
WITHDRAWN
M Health Fairview Masonic Children's Hospital, Minneapolis
RECRUITING
Mayo Eugenio Litta Children's Hospital, Rochester
RECRUITING
Sanford Children's Hospital, Sious Falls
RECRUITING
Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
RECRUITING
Comer Children's Hospital, Chicago
RECRUITING
OSF Healthcare Children's Hospital of Illinois, Peoria
RECRUITING
Cardinal Glennon Children's Hospital, St Louis
RECRUITING
St. Louis Children's Hospital, St Louis
RECRUITING
Children's Mercy, Kansas City
RECRUITING
Children's Nebraska, Omaha
RECRUITING
Ochsner LSU Health Shreveport, Shreveport
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Oklahoma Children's Hospital OU Health, Oklahoma City
RECRUITING
Medical City Children's Hospital, Dallas
RECRUITING
Children's Medical Center Dallas, Dallas
RECRUITING
Children's Memorial Hermann Hospital, Houston
RECRUITING
Texas Children's Hospital, Houston
RECRUITING
University Health Women's & Children's Hospital, San Antonio
RECRUITING
Dell Children's Medical Center, Austin
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Primary Children's Hospital, Salt Lake City
RECRUITING
Phoenix Children's Hospital, Phoenix
RECRUITING
UNM Children's Hospital, Albuquerque
RECRUITING
UCLA Mattel Children's Hospital, Los Angeles
RECRUITING
Loma Linda University Children's Hospital, Loma Linda
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Benioff Children's Hospital - San Francisco, San Francisco
RECRUITING
Lucile Packard Children's Hospital Stanford, Palo Alto
RECRUITING
UCSF Benioff Children's Hospital Oakland, Oakland
RECRUITING
Kapi'olani Medical Center for Women & Children, Honolulu
RECRUITING
OHSU Doernbecher Children's Hospital, Portland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Fundacion Cardiovascular De Colombia, Floridablanca
RECRUITING
Pontificia Universidad, Santiago
RECRUITING
Connecticut Children's Medical Center, Hartford
RECRUITING
Yale New Haven Children's Hospital, New Haven
RECRUITING
Boston Children's Hospital, Boston
RECRUITING
"Atrium Health Wake Forest Baptist , Brenner Children's Hospital"
RECRUITING
Hasbro Children's, Providence
RECRUITING
The Royal Children's Hospital Melbourne, Melbourne
RECRUITING
Perth Children's Hospital, Perth
RECRUITING
Queensland Children's Hospital, South Brisbane
RECRUITING
The Children's Hospital at Westmead, Westmead
RECRUITING
Stollery Children's Hospital, Edmonton
RECRUITING
The Hospital for Sick Children, Toronto
RECRUITING
Hospital de Santa Maria, Lisbon
RECRUITING
Children's Hospital and Vall d' Hebron Women's Hospital, Barcelona
RECRUITING
Sant Joan de Deu Barcelona Hospital, Barcelona
RECRUITING
Royal Hospital for Children, Glasgow
RECRUITING
Leicester Children's Hospital, Leicester
RECRUITING
Alder Hey Children's Hospital, Liverpool
RECRUITING
Evelina London Children's Hospital, London
RECRUITING
Royal Brompton Hospital, London
RECRUITING
Great Ormond Street Hospital for Children, London
RECRUITING
Freeman Hospital, Newcastle upon Tyne
RECRUITING
Southampton Children's Hospital, Southampton
National Heart, Lung, and Blood Institute (NHLBI)
NIH
University of Michigan
OTHER