A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

418

Participants

Timeline

Start Date

August 5, 2022

Primary Completion Date

January 3, 2024

Study Completion Date

June 30, 2026

Conditions
Advanced or Metastatic Non-small Cell Lung Cancer
Interventions
DRUG

Lazertinib

Lazertinib tablets will be administered orally.

DRUG

Amivantamab Subcutaneous and Co-Formulated with Recombinant Human Hyaluronidase (SC CF)

Amivantamab injection will be administered subcutaneously by manual injection.

DRUG

Amivantamab Intravenous

Amivantamab will be administered by IV infusion.

Trial Locations (187)

106

National Taiwan University Cancer Center, Taipei

403

Chung Shan Medical University Hospital, Taichung

833

Chang Kung Memorial Hospital, Kaohsiung City

1431

CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires

2050

Chris O'Brien Lifehouse, Camperdown

2145

Westmead Hospital, Westmead

3000

Peter MacCallum Cancer Centre, Melbourne

4102

Princess Alexandra Hospital, Woolloongabba

5000

Cemaic Centro Privado de Especialidades Medicas Ambulatorias e Investigacion Clinica, Córdoba

Sanatorio Allende, Córdoba

Cancer Research SA, Adelaide

6150

St John of God Hospital Murdoch, Murdoch

8028

Hosp. Univ. Quiron Dexeus, Barcelona

10016

NYU Langone Health Laura and Isaac Perlmutter Cancer Center, New York

10043

Aou San Luigi Gonzaga, Orbassano

10048

National Taiwan University Hospital, Taipei

10400

Phramongkutklao Hospital and Medical College, Bangkok

10408

National Cancer Center, Gyeonggi-do

10461

Montefiore Medical Center, The Bronx

10700

Siriraj Hospital, Bangkok

13125

Evangelische Lungenklinik Berlin, Berlin

13496

CHA Bundang Medical Center, CHA University, Gyeonggi-do

13620

Seoul National University Bundang Hospital, Seongnam-si

13915

Hopital Nord, Marseille

14004

Hosp Reina Sofia, Córdoba

15006

Hosp Univ A Coruna, A Coruña

19104

University of Pennsylvania Division of Hematology Oncology Perelman Center for Advanced Medicine, Philadelphia

20089

Istituto Clinico Humanitas, Rozzano

20141

European Institute of Oncology, Milan

22030

Trakya University Medical Faculty, Edirne

22031

Virginia Cancer Specialists, Fairfax

27003

Hosp. Univ. Lucus Augusti, Lugo

28009

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28046

Hosp. Univ. La Paz, Madrid

28222

Hosp. Univ. Pta. de Hierro Majadahonda, Majadahonda

29011

Hosp Regional Univ de Malaga, Málaga

29425

Medical University of South Carolina, Charleston

32806

Orlando Health, Orlando

33011

Hosp. Univ. Central de Asturias, Oviedo

33382

Linkou Chang Gung Memorial Hospital, Taoyuan District

33486

Baptist Lynn Cancer Institute, Boca Raton

34098

Istanbul University Cerrahpasa Medical Faculty, Istanbul

34457

Acıbadem Maslak Hospital, Istanbul

35016

Hosp. Univ. Insular de Gran Canaria, Las Palmas de Gran Canaria

35128

Istituto Oncologico Veneto - IRCCS, Padua

35330

Dokuz Eylul University Medical Faculty, Izmir

35392

Universitaetsklinikum Giessen und Marburg GmbH, Giessen

35575

IEU Medical Point Hospital, Izmir

38700

CHU Grenoble, La Tronche

40138

A O U Sant Orsola Malpighi, Bologna

41013

Hosp. Virgen Del Rocio, Seville

44281

Meir Medical Center, Kfar Saba

45659

Oncologianova GmbH, Recklinghausen

46026

Hosp. Univ. I Politecni La Fe, Valencia

46050

Beacon Hospital Sdn Bhd, Petaling Jaya

47500

Sunway Medical Centre, Petaling Jaya

48109

University of Michigan, Ann Arbor

48121

Ospedale S. Maria Delle Croci, Ravenna

48149

Munster University Hospital, Münster

49100

Rabin Medical Center, Petah Tikva

49124

Niels-Stensen-Kliniken Franziskus-Hospital Harderberg, Georgsmarienhütte

50006

Changhua Christian Hospital, Changhua

50200

Chiang Mai University, Chiang Mai

50450

Prince Court Medical Centre, Kuala Lumpur

52727

GyeongSang National University Hospital, Gyeongsangnam-do

55200

Medical Park Samsun Hastanesi, Samsun

58128

Chonnam National University Hwasun Hospital, Jeollanam-do

59000

Institute Coeur Poumon, Lille

59100

Pantai Hospital Kuala Lumpur, Kuala Lumpur

University Malaya Medical Centre, Kuala Lumpur

66160

University of Kansas, Kansas City

70124

Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo II, Bari

70403

National Cheng Kung University Hospital, Tainan City

74189

Onkologische Schwerpunktpraxis, Weinsberg

80206

National Jewish Health, Denver

80756

Kaohsiung Medical University Chung Ho Memorial Hospital, Kaohsiung City

87000

CHU de Limoges Hopital Dupuytren, Limoges

90813

City of Hope Long Beach Elm, Long Beach

91010

City of Hope Duarte, Duarte

91031

Shaare Zedek Medical Center, Jerusalem

92618

City of Hope Orange County Lennar Foundation Cancer Center, Irvine

93586

Hospital Umum Sarawak, Kuching

97213

Providence Portland Medical Center, Portland

97225

Providence Oncology and Hematology Care Clinic Westside, Portland

100038

Beijing Shijitan Hospital, Capital Medical University, Beijing

100050

Beijing Friendship Hospital Capital Medical University, Beijing

100191

Peking University Third Hospital, Beijing

101149

Beijing Chest hospital, Capital medical university, Beijing

110004

Shengjing Hospital Of China Medical University, Shenyang

130012

Jilin cancer hospital, Changchun

150081

Harbin medical university cancer hospital, Harbin

200032

Fudan University Shanghai Cancer Center, Shanghai

200240

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

213004

The First People's Hospital Of Changzhou, Changzhou

264000

Yantai Yuhuangding Hospital, Yantai

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310009

The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou

310016

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

341000

First Affiliated Hospital of Gannan Medical University, Ganzhou

400030

Chongqing University Cancer Hospital, Chongqing

400038

Southwest Hospital, Chongqing

430022

Union Hospital Tongji Medical College of Huazhong University of Science and Technology, Wuhan

441021

Xiangyang Central Hospital, Xiangyang

450008

Henan Cancer Hospital, Zhengzhou

510000

Sun Yat-Sen Memorial Hospital Sun Yat-sen University, Guangzhou

510080

The First Affiliated Hospital Sun Yat sen University, Guangzhou

516001

Huizhou Municipal Central Hospital, Huizhou

516003

Huizhou First Hospital, Huizhou

518001

Shenzhen People s Hospital, Shenzhen

518055

Shenzhen university General Hospital, Shenzhen

545026

Liuzhou people's Hospital, Liuzhou

610041

Sichuan Cancer Hospital, Chengdu

610047

West China Hospital Sichuan University, Chengdu

637100

Affiliated Hospital of North Sichuan Medical College, Nanchong

710061

The First Affiliated Hospital of Xian Jiaotong University, Xi'an

3109601

Rambam Medical Center, Haifa

5262100

Chaim Sheba Medical Center, Ramat Gan

08816

Astera Cancer Care, East Brunswick

08901

Rutgers Cancer Institute of New Jersey, New Brunswick

C1426AGE

Centro Oncológico Korben, Buenos Aires

C1122

IADT Instituto Argentino de Diagnostico y Tratamiento, CABA

R8500ACE

Clínica Viedma, Viedma

14784-400

Fundacao Pio XII, Barretos

30110-017

Cetus Oncologia, Belo Horizonte

80810-050

Instituto Cionc de Ensino e Pesquisa S/S, Curitiba

88020-210

Ynova Pesquisa Clinica, Florianópolis

35162 189

Fundacao Sao Francisco Xavier HMC Unidade de Oncologia, Ipatinga

96020 080

UPCO Unidade de Pesquisa Clinica em Oncologia, Pelotas

90610-000

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre

22061-080

Impar Servicos Hospitalares S/A, Rio de Janeiro

22250 905

Oncoclinicas Rio de Janeiro S A, Rio de Janeiro

22281 100

Instituto D Or de Pesquisa e Ensino IDOR, Rio de Janeiro

40170 110

Nucleo de Oncologia da Bahia, Salvador

09060-650

CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia, Santo André

01409-002

Impar Servicos Hospitalares SA Hospital Nove de Julho, São Paulo

04014-002

Núcleo de Pesquisa São Camilo, São Paulo

04543-000

Onco Star SP Oncologia Ltda, São Paulo

05652 900

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

K1H 8L6

The Ottawa Hospital Cancer Centre, Ottawa

M5G 1Z5

Princess Margaret Hospital, Toronto

00152

A.O. San Camillo Forlanini, Roma

00144

Istituto Nazionale Tumori Regina Elena, Rome

104 0045

National Cancer Center Hospital, Chūōku

670-8520

National Hospital Organization Himeji Medical Center, Himeji

573 1191

Kansai Medical University Hospital, Hirakata

241-8515

Kanagawa Cancer Center, Kanagawa

710-8602

Kurashiki Central Hospital, Kurashiki

830-0011

Kurume University Hospital, Kurume

515-8544

Matsusaka Municipal Hospital, Matsusaka

951-8566

Niigata Cancer Center Hospital, Niigata

700 8558

Okayama University Hospital, Okayama

541 8567

Osaka International Cancer Institute, Osaka

060-8648

Hokkaido University Hospital, Sapporo

411 8777

Shizuoka Cancer Center, Shizuoka

135 8550

The Cancer Institute Hospital of JFCR, Tokyo

470-1192

Fujita Health University Hospital, Toyoake

560-8552

National Hospital Organization Osaka Toneyama Medical Center, Toyonaka-shi

641 8510

Wakayama Medical University Hospital, Wakayama

740-8510

National Hospital Organization Iwakuni Clinical Center, Yamaguchi

755-0241

National Hospital Organization Yamaguchi Ube Medical Center, Yamaguchi

85 796

Centrum Onkologii im Prof F Lukaszczyka w Bydgoszczy, Bydgoszcz

31-202

Krakowski Szpital Specjalityczny im. Jana Pawla II, Krakow

05 400

Mazowieckie Centrum Leczenia Chorob Pluc, Otwock

60-693

Private Specialist Hospitals - MedPolonia, Poznan

02-781

Narodowy Instytut Onkologii im Marii Sklodowskiej Curie Panstwowy Instytut Badawczy, Warsaw

4710-243

Hospital de Braga, Braga

1500-650

Hospital da Luz, SA, Lisbon

1998-018

Hosp. Cuf Descobertas, Lisbon

4464-513

Ulsm - Hosp. Pedro Hispano, Senhora da Hora

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

03010

Hosp. Gral. Univ. de Alicante, Alicante

08035

Hosp Univ Vall D Hebron, Barcelona

08036

Hosp Clinic de Barcelona, Barcelona

07120

Hosp. Univ. Son Espases, Palma de Mallorca

01060

Adana City Hospital, Adana

01120

Adana Baskent Hospital, Adana

06520

Memorial Ankara Hastanesi, Ankara

06560

Gazi University Hospital, Ankara

06800

Ankara Bilkent City Hospital, Ankara

B9 5SS

Birmingham Heartlands Hospital, Birmingham

W2 1NY

Imperial College Healthcare, London

NE7 7DN

Newcastle Freeman Hospital, Newcastle upon Tyne

SM2 5PT

Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY