Biomarker-Driven Radiation Therapy Dose Reduction After Transoral Robotic Surgery for the Treatment of HPV-Positive Oropharyngeal Cancer

PHASE2Active, not recruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

June 6, 2022

Primary Completion Date

December 10, 2025

Study Completion Date

May 5, 2026

Conditions

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Oropharyngeal HPV-Positive Squamous Cell Carcinoma

Interventions

RADIATION

Radiation Therapy

Undergo reduced dose radiation therapy

Trial Locations (3)

Emory University Midtown Hospital, Atlanta

Emory University Hospital/Winship Cancer Institute, Atlanta

Vanderbilt University Medical Center, Nashville

All Listed Sponsors

collaborator

National Cancer Institute (NCI)

NIH

lead

Emory University

OTHER