HPV Screening With Triage by HPV Genotyping Versus Visual Inspection With Acetic Acid

NARecruitingINTERVENTIONAL
Enrollment

5,500

Participants

Timeline

Start Date

December 6, 2022

Primary Completion Date

June 30, 2025

Study Completion Date

June 30, 2026

Conditions
Cervical Cancer
Interventions
DIAGNOSTIC_TEST

HPV genotyping

Genotyping will be obtained by the Xpert system which uses 5 color channels containing primers and probes for the detection of specific genotypes or pooled results as follows: i) HPV 16, ii) HPV 18/45 in pooled result, iii) HPV types 31, 33, 35 52, or 58, in pooled result, iv) HPV types 51 or 59, in pooled result, and v) HPV types 39, 56, 66 or 68 in pooled result.

DIAGNOSTIC_TEST

Visual inspection after application of acetic acid

"After application of acetic acid and Lugol's iodine, the cervix will be assessed using simplified ABCD criteria (A= acetowhite lesion within the transformation zone, B = spontaneous bleeding or upon slight touch, C (optional) = Lugol-positive coloring of acetowhite lesions, D = diameter \> 5mm of acetowhite lesion)."

Trial Locations (2)

Unknown

RECRUITING

Dschang Annex Regional Hospital, Dschang

NOT_YET_RECRUITING

Bafoussam Regional Hospital, Bafoussam

All Listed Sponsors
collaborator

University Hospital, Geneva

OTHER

collaborator

Bafoussam Regional Hospital, Cameroon

UNKNOWN

collaborator

Dschang District Hospital, Cameroon

UNKNOWN

collaborator

University of Dschang

OTHER

lead

Prof. Patrick Petignat

OTHER