A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

PHASE3RecruitingINTERVENTIONAL
Enrollment

225

Participants

Timeline

Start Date

February 20, 2023

Primary Completion Date

December 20, 2027

Study Completion Date

December 20, 2027

Conditions
Childhood Medulloblastoma
Interventions
PROCEDURE

Audiometric Test

Ancillary studies

PROCEDURE

Auditory Brainstem Response

Ancillary studies

PROCEDURE

Biospecimen Collection

Undergo CSF and blood sample collection

DRUG

Cisplatin

Given IV

DRUG

Cyclophosphamide

Given IV

DRUG

Lomustine

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Quality-of-Life Assessment

Ancillary studies

RADIATION

Radiation Therapy

Undergo radiation therapy

DRUG

Sodium Thiosulfate

Given IV

OTHER

Survey Administration

Ancillary studies

DRUG

Vincristine

Given IV

Trial Locations (91)

10467

SUSPENDED

Montefiore Medical Center - Moses Campus, The Bronx

10595

RECRUITING

New York Medical College, Valhalla

11040

RECRUITING

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

12208

RECRUITING

Albany Medical Center, Albany

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17822

RECRUITING

Geisinger Medical Center, Danville

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27834

RECRUITING

East Carolina University, Greenville

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

29605

RECRUITING

BI-LO Charities Children's Cancer Center, Greenville

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33155

RECRUITING

Nicklaus Children's Hospital, Miami

33607

RECRUITING

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa

33908

RECRUITING

Golisano Children's Hospital of Southwest Florida, Fort Myers

35233

SUSPENDED

Children's Hospital of Alabama, Birmingham

36604

RECRUITING

USA Health Strada Patient Care Center, Mobile

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40202

RECRUITING

Norton Children's Hospital, Louisville

43205

RECRUITING

Nationwide Children's Hospital, Columbus

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44106

RECRUITING

Rainbow Babies and Childrens Hospital, Cleveland

44308

RECRUITING

Children's Hospital Medical Center of Akron, Akron

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

RECRUITING

Dayton Children's Hospital, Dayton

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48073

RECRUITING

Corewell Health Children's, Royal Oak

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

48201

RECRUITING

Children's Hospital of Michigan, Detroit

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

RECRUITING

Children's Hospital of Wisconsin, Milwaukee

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54449

SUSPENDED

Marshfield Medical Center-Marshfield, Marshfield

55404

RECRUITING

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

60612

RECRUITING

University of Illinois, Chicago

61637

RECRUITING

Saint Jude Midwest Affiliate, Peoria

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

63104

RECRUITING

Cardinal Glennon Children's Medical Center, St Louis

63110

RECRUITING

Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70118

RECRUITING

Children's Hospital New Orleans, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75230

RECRUITING

Medical City Dallas Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79905

RECRUITING

El Paso Children's Hospital, El Paso

80045

RECRUITING

Children's Hospital Colorado, Aurora

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

90806

RECRUITING

Miller Children's and Women's Hospital Long Beach, Long Beach

92123

RECRUITING

Rady Children's Hospital - San Diego, San Diego

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92868

RECRUITING

Children's Hospital of Orange County, Orange

93636

RECRUITING

Valley Children's Hospital, Madera

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

97227

RECRUITING

Legacy Emanuel Children's Hospital, Portland

97239

RECRUITING

Oregon Health and Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

06520

RECRUITING

Yale University, New Haven

02114

RECRUITING

Massachusetts General Hospital Cancer Center, Boston

08901

RECRUITING

Saint Peter's University Hospital, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07503

RECRUITING

Saint Joseph's Regional Medical Center, Paterson

02903

RECRUITING

Rhode Island Hospital, Providence

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK