225
Participants
Start Date
February 20, 2023
Primary Completion Date
December 20, 2027
Study Completion Date
December 20, 2027
Audiometric Test
Ancillary studies
Auditory Brainstem Response
Ancillary studies
Biospecimen Collection
Undergo CSF and blood sample collection
Cisplatin
Given IV
Cyclophosphamide
Given IV
Lomustine
Given PO
Magnetic Resonance Imaging
Undergo MRI
Quality-of-Life Assessment
Ancillary studies
Radiation Therapy
Undergo radiation therapy
Sodium Thiosulfate
Given IV
Survey Administration
Ancillary studies
Vincristine
Given IV
SUSPENDED
Montefiore Medical Center - Moses Campus, The Bronx
RECRUITING
New York Medical College, Valhalla
RECRUITING
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park
RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Albany Medical Center, Albany
RECRUITING
State University of New York Upstate Medical University, Syracuse
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Geisinger Medical Center, Danville
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Alfred I duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Sinai Hospital of Baltimore, Baltimore
RECRUITING
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
RECRUITING
University of Virginia Cancer Center, Charlottesville
RECRUITING
VCU Massey Comprehensive Cancer Center, Richmond
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
East Carolina University, Greenville
RECRUITING
Prisma Health Richland Hospital, Columbia
RECRUITING
BI-LO Charities Children's Cancer Center, Greenville
RECRUITING
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta
RECRUITING
Nemours Children's Clinic-Jacksonville, Jacksonville
RECRUITING
Arnold Palmer Hospital for Children, Orlando
RECRUITING
Nemours Children's Hospital, Orlando
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Nicklaus Children's Hospital, Miami
RECRUITING
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa
RECRUITING
Golisano Children's Hospital of Southwest Florida, Fort Myers
SUSPENDED
Children's Hospital of Alabama, Birmingham
RECRUITING
USA Health Strada Patient Care Center, Mobile
RECRUITING
Vanderbilt University/Ingram Cancer Center, Nashville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
Norton Children's Hospital, Louisville
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo
RECRUITING
Rainbow Babies and Childrens Hospital, Cleveland
RECRUITING
Children's Hospital Medical Center of Akron, Akron
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Dayton Children's Hospital, Dayton
RECRUITING
Riley Hospital for Children, Indianapolis
RECRUITING
Corewell Health Children's, Royal Oak
RECRUITING
C S Mott Children's Hospital, Ann Arbor
RECRUITING
Children's Hospital of Michigan, Detroit
RECRUITING
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
SUSPENDED
Marshfield Medical Center-Marshfield, Marshfield
RECRUITING
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
University of Illinois, Chicago
RECRUITING
Saint Jude Midwest Affiliate, Peoria
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Children's Hospital and Medical Center of Omaha, Omaha
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Children's Hospital New Orleans, New Orleans
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Medical City Dallas Hospital, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
Children's Hospital of San Antonio, San Antonio
RECRUITING
University of Texas Health Science Center at San Antonio, San Antonio
RECRUITING
Dell Children's Medical Center of Central Texas, Austin
RECRUITING
El Paso Children's Hospital, El Paso
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Phoenix Childrens Hospital, Phoenix
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
Miller Children's and Women's Hospital Long Beach, Long Beach
RECRUITING
Rady Children's Hospital - San Diego, San Diego
RECRUITING
Loma Linda University Medical Center, Loma Linda
RECRUITING
Children's Hospital of Orange County, Orange
RECRUITING
Valley Children's Hospital, Madera
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Kaiser Permanente-Oakland, Oakland
RECRUITING
Legacy Emanuel Children's Hospital, Portland
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Seattle Children's Hospital, Seattle
RECRUITING
Mary Bridge Children's Hospital and Health Center, Tacoma
RECRUITING
Providence Sacred Heart Medical Center and Children's Hospital, Spokane
RECRUITING
Arkansas Children's Hospital, Little Rock
RECRUITING
Yale University, New Haven
RECRUITING
Massachusetts General Hospital Cancer Center, Boston
RECRUITING
Saint Peter's University Hospital, New Brunswick
RECRUITING
Newark Beth Israel Medical Center, Newark
RECRUITING
Saint Joseph's Regional Medical Center, Paterson
RECRUITING
Rhode Island Hospital, Providence
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Centre Hospitalier Universitaire Sainte-Justine, Montreal
National Cancer Institute (NCI)
NIH
Children's Oncology Group
NETWORK