1
Participants
Start Date
June 15, 2022
Primary Completion Date
December 31, 2023
Study Completion Date
December 31, 2023
Inspiratory hold
A short period (\< 30 seconds) during which both inspiratory and expiratory valves of the ventilator circuit are closed at the end of inspiration. It is used to asses expiratory force generation (maximal expiratory pressure, MEP) and frequently used in clinical practice.
Expiratory hold
A short period (\< 30 seconds) during which both inspiratory and expiratory valves of the ventilator circuit are closed at the end of expiration. It is used to asses static PEEP and inspiratory force generation (maximal inspiratory pressure, MIP \& occlusion pressure, ∆Pocc) and is frequently used in clinical practice.
Ultrasound of respiratory muscles
Ultrasound of the diaphragm, parasternal intercostal muscle and internal oblique muscle will be performed during each block. Thickening fractions, calculated as thickness at end-inspiration minus thickness at end-expiration divided by thickness at end-expiration, are used to assess the contribution of the muscle to the tidal volume. A median over 5 breaths will be calculated.
PEEP 10
Positive End-Expiratory Pressure of 10cmH2O for 30 minutes
PEEP 5
Positive End-Expiratory Pressure of 5cmH2O for 30 minutes
PEEP 0
Positive End-Expiratory Pressure of 0cmH2O for 30 minutes
Antwerp University Hospital, Edegem
Research Foundation Flanders
OTHER
University Hospital, Antwerp
OTHER