Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease

PHASE3CompletedINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

July 22, 2022

Primary Completion Date

April 4, 2023

Study Completion Date

April 4, 2023

Conditions
Dry Eye Disease
Interventions
DRUG

Varenicline Tartrate Nasal Spray

Intranasal delivery of OC-01 (varenicline solution) 0.6 mg/mL twice a day (BID) for 28 days

DRUG

Placebo (vehicle)

Intranasal delivery of placebo (vehicle) twice a day (BID) for 28 days

Trial Locations (20)

100730

Beijing Tongren Hospital, Beijing

Unknown

The Second Hospital of Anhui Medical University, Hefei

Beijing Hospital, Beijing

Peking University Third Hospital, Beijing

Zhujiang Hospital of Southern Medical University, Guangzhou

The Affiliated Hospital of Guizhou Medical University, Guiyang

Shijiazhuang People's Hospital, Shijiazhuang

Hebei Eye Hospital, Xingtai

The First Affiliated Hospital of Harbin Medical University, Harbin

Henan Eye Hospital, Zhengzhou

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

Wuhan Aier Eye Hospital Hankou Hospital, Wuhan

Nanjing First Hospital, Nanjing

The First Bethune Hospital of Jilin University, Changchun

Eye Hospital of Shandong First Medical University, Jinan

Weifang Eye Hospital, Weifang

Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

Tongji Hospital of Tongji University, Shanghai

Tianjin Medical University Eye Hospital, Tianjin

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

Sponsors
All Listed Sponsors
collaborator

Oyster Point Pharma, Inc.

INDUSTRY

lead

Corxel Pharmaceuticals

INDUSTRY

NCT05378945 - Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease | Biotech Hunter | Biotech Hunter