432
Participants
Start Date
July 1, 2022
Primary Completion Date
July 2, 2025
Study Completion Date
June 30, 2026
TQB3616 capsule
TQB3616 capsule is a CDK (cyclin-dependent kinases) 4/6 kinase inhibitor, which can selectively inhibit THE activity of CDK4/6 kinase, make it form a complex with Cyclin D, reduce the phosphorylation level of retinoblastoma protein (Rb) in cancer cells, and prevent cells from entering S phase from G1 phase
Placebo
It is a placebo
Fulvestrant injection
Fulvestrant is a competitive estrogen receptor antagonist, and its mechanism is related to the down-regulation of estrogen receptor (ER) protein level
Henan Cancer Hospital, Zhengzhou
Peking University First Hospital, Beijing
Beijing Cancer Hospital, Beijing
The First Affiliated Hospital of China Medical University, Shenyang
Liaoning Cancer Hospital & Institute, Shenyang
The Second Hosptial of DaLian Medical University, Dalian
Affiliated Zhongshan Hospital of Dalian University, Dalian
The First Affiliated Hospital of Jinzhou Medical University, Jinzhou
Jilin Cancer Hospital, Changchun
The First Hospital of Jilin University, Changchun
Second Hospital of Jilin University, Changchun
Affiliated Cancer Hospital of Harbin Medical University, Harbin
The Second Affiliated Hospital of Harbin Medical University, Harbin
Jiamusi Cancer Hospital, Jiamusi
Huadong Hospital, Shanghai
Shanghai Oriental Hospital, Shanghai
Shanghai Changhai Hospital, Shanghai
Nanjing Drum Tower Hospital, Nanjing
Jiangsu province hospital, Nanjing
Changzhou Cancer Hospital, Changzhou
The Affiliated Hospital of Xuzhou Medical University, Xuzhou
Huai'an First People's Hospital, Huai'an
Affiliated Hospital of Nantong University, Nantong
The First Affiliated Hospital of Bengbu Medical College, Bengbu
The First Affiliated Hospital of Wannan Medical College, Wuhu
Shandong Cancer Hospital, Jinan
Zibo Central Hospital, Zibo
Binzhou Medical College Affiliated Hospital, Binzhou
Weifang Hospital of Traditional Chinese Midicine, Weifang
Yantai Yantai Mountain hospital, Yantai
Qingdao University Affiliated Hospital, Qingdao
Affiliated Hospital of Jining Medical University, Jining
Linyin Cancer Hospital, Linyi
Tianjin Medical University Cancer Hospital, Tianjin
Tianjin Medical University Cancer Hospital Konggang Hospital, Tianjin
Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medcine, Hangzhou
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
The Third Hospital of Nanchang, Nanchang
The First Affiliated Hospital of Gannan Medical University, Ganzhou
Fujian Provincial Cancer Hospital, Fuzhou
Chongqing University Cancer Hospital, Chongqing
The Southwest Hospital of AMU, Chongqing
The Second Xiangya Hospital of Central South University, Changsha
Xiangya Hospital of Central South University, Changsha
Hunan Cancer Hospital, Changsha
The First People's Hospital of Changde, Changde
Yichang Central People's Hospital, Yichang
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
Luoyang Central Hospital, Luoyang
Nanyang Central Hospital, Nanyang
Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou
Nanfang Hospital Southern Medical University, Guangzhou
The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou
Yue Bei People's Hospital, Shaoguan
ShenZhen People's Hospital, Shenzhen
PeKing University ShenZhen Hosipital, Shenzhen
The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai
Jieyang People's Hospital, Jieyang
Maoming people's hospital, Maoming
Zhongshan City People's Hospital, Zhongshan
Yulin First People's Hospital, Yulin
The Second Affiliated Hospital of Guilin Medical University, Guilin
Chinese People's Liberation Army Western Theater General Hospital, Chengdu
Suining Central Hospital, Suining
The Affiliated Hospital of Southwest Medical University, Luzhou
Yunnan Cancel Hospital, Kunming
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an
First Affiliated University Hospital of PLA Air Force Military Medical, Xi'an
Second Affiliated Hospital of PLA Air Force Military Medical, Xi'an
Xi'an International Medical Center Hospital, Xi'an
Gansu Provincial Cancer Hospital, Lanzhou
Gansu Wuwei Tumour Hospital, Wuwei
Lanzhou University Second Hospital, Lanzhou
General Hospital of Ningxia Medical, Yinchuan
Qinghai University affiliated hospital, Xining
Cancer Hospital affiliated to Xinjiang Medical University, Ürümqi
The Affiliated Hospital of Hebei University, Baoding
Cangzhou Central Hospital, Cangzhou
Hebei Cangzhou Hospital of Integrated Traditional Chinese, Cangzhou
Affiliated Hospital of Chengde Medical University, Chengde
Hebei Petro China Central Hospital, Langfang
The Fourth Hospital of Hebei Medical University, Shijiazhuang
Affiliated Hospital of Chifeng University, Chifeng
Inner Mongolia Autonomous Region Cancer Hospital, Hohhot
The Affilliate Hospital of Inner Mongolia Medical Univercity, Hohhot
Changzhi People's Hospital, Changzhi
Shanxi Cancer Hospital, Taiyuan
Lead Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
INDUSTRY