An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study

RecruitingOBSERVATIONAL
Enrollment

2,100

Participants

Timeline

Start Date

April 26, 2022

Primary Completion Date

October 31, 2026

Study Completion Date

January 31, 2030

Conditions
Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Interventions
PROCEDURE

Biospecimen Collection

Undergo collection of tumor, blood, saliva and stool samples

OTHER

Electronic Health Record Review

Review of medical records

OTHER

Interview

Complete an interview

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Complete questionnaires

Trial Locations (259)

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

14642

RECRUITING

University of Rochester, Rochester

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19718

RECRUITING

Christiana Care Health System-Christiana Hospital, Newark

19801

RECRUITING

Christiana Care Health System-Wilmington Hospital, Wilmington

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

20010

RECRUITING

MedStar Washington Hospital Center, Washington D.C.

21921

RECRUITING

Christiana Care - Union Hospital, Elkton

23113

RECRUITING

Bon Secours Westchester Emergency Center, Midlothian

23114

RECRUITING

Bon Secours Saint Francis Medical Center, Midlothian

23116

RECRUITING

Bon Secours Memorial Regional Medical Center, Mechanicsville

23226

RECRUITING

Bon Secours Saint Mary's Hospital, Richmond

23230

RECRUITING

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

28054

RECRUITING

CaroMont Regional Medical Center, Gastonia

28374

RECRUITING

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28561

RECRUITING

CarolinaEast Medical Center, New Bern

28721

RECRUITING

AdventHealth Infusion Center Haywood, Clyde

28787

RECRUITING

AdventHealth Infusion Center Weaverville, Weaverville

28792

RECRUITING

AdventHealth Hendersonville, Hendersonville

28803

RECRUITING

AdventHealth Infusion Center Asheville, Asheville

29303

RECRUITING

Spartanburg Medical Center, Spartanburg

29316

RECRUITING

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29341

RECRUITING

Gibbs Cancer Center-Gaffney, Gaffney

29379

RECRUITING

SMC Center for Hematology Oncology Union, Union

29425

RECRUITING

Medical University of South Carolina, Charleston

29440

RECRUITING

Tidelands Georgetown Memorial Hospital, Georgetown

RECRUITING

Waccamaw Oncology - Georgetown, Georgetown

29576

RECRUITING

Waccamaw Oncology-Murrells Inlet, Murrells Inlet

29577

RECRUITING

Waccamaw Oncology-Myrtle Beach, Myrtle Beach

29601

RECRUITING

Saint Francis Hospital, Greenville

29605

RECRUITING

Prisma Health Cancer Institute - Butternut, Greenville

RECRUITING

Prisma Health Cancer Institute - Faris, Greenville

29607

RECRUITING

Saint Francis Cancer Center, Greenville

29615

RECRUITING

Prisma Health Cancer Institute - Eastside, Greenville

29621

RECRUITING

AnMed Health Cancer Center, Anderson

29640

RECRUITING

Prisma Health Cancer Institute - Easley, Easley

29646

RECRUITING

Self Regional Healthcare, Greenwood

29650

RECRUITING

Prisma Health Cancer Institute - Greer, Greer

29651

RECRUITING

Gibbs Cancer Center-Pelham, Greer

29672

RECRUITING

Prisma Health Cancer Institute - Seneca, Seneca

29902

RECRUITING

Beaufort Memorial Hospital, Beaufort

29909

RECRUITING

Beaufort Memorial/New River Cancer Center, Okatie

29910

RECRUITING

Saint Joseph's/Candler - Bluffton Campus, Bluffton

30046

RECRUITING

Northside Hospital - Gwinnett, Lawrenceville

30078

RECRUITING

Suburban Hematology Oncology Associates - Snellville, Snellville

30096

RECRUITING

Northside Hospital - Duluth, Duluth

30342

RECRUITING

Northside Hospital, Atlanta

30912

RECRUITING

Augusta University Medical Center, Augusta

31405

RECRUITING

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah

31602

RECRUITING

South Georgia Medical Center/Pearlman Cancer Center, Valdosta

31794

RECRUITING

Tift Regional Medical Center, Tifton

31904

RECRUITING

John B Amos Cancer Center, Columbus

38017

RECRUITING

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

RECRUITING

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38652

RECRUITING

Baptist Memorial Hospital and Cancer Center-Union County, New Albany

38655

RECRUITING

Baptist Memorial Hospital and Cancer Center-Oxford, Oxford

38671

RECRUITING

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

38901

RECRUITING

Baptist Cancer Center-Grenada, Grenada

39202

RECRUITING

Jackson Oncology Associates PLLC, Jackson

RECRUITING

Mississippi Baptist Medical Center, Jackson

39502

RECRUITING

Gulfport Memorial Hospital, Gulfport

39705

RECRUITING

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus

45005

RECRUITING

Dayton Physicians LLC-Atrium, Franklin

45429

RECRUITING

Kettering Medical Center, Kettering

45431

RECRUITING

Indu and Raj Soin Medical Center, Beavercreek

45840

RECRUITING

Armes Family Cancer Center, Findlay

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48114

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health Medical Center - Canton, Canton

48341

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48503

RECRUITING

Cancer Hematology Centers - Flint, Flint

RECRUITING

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

49444

RECRUITING

Trinity Health Muskegon Hospital, Muskegon

RECRUITING

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

49519

RECRUITING

University of Michigan Health - West, Wyoming

49677

RECRUITING

Corewell Health Reed City Hospital, Reed City

53014

RECRUITING

Ascension Calumet Hospital, Chilton

53045

RECRUITING

Ascension Southeast Wisconsin Hospital - Elmbrook Campus, Brookfield

53097

RECRUITING

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon

53132

RECRUITING

Ascension Saint Francis - Reiman Cancer Center, Franklin

53211

RECRUITING

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee

53226

RECRUITING

Ascension Medical Group Southeast Wisconsin - Mayfair Road, Wauwatosa

53405

RECRUITING

Ascension All Saints Hospital, Racine

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54166

RECRUITING

ThedaCare Cancer Care - Shawano, Shawano

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

RECRUITING

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

54701

SUSPENDED

HSHS Sacred Heart Hospital, Eau Claire

54904

RECRUITING

Ascension Mercy Hospital, Oshkosh

RECRUITING

ThedaCare Cancer Care - Oshkosh, Oshkosh

54911

RECRUITING

ThedaCare Regional Cancer Center, Appleton

54915

RECRUITING

Ascension Saint Elizabeth Hospital, Appleton

54923

RECRUITING

ThedaCare Cancer Care - Berlin, Berlin

54956

RECRUITING

ThedaCare Regional Medical Center - Neenah, Neenah

54961

RECRUITING

ThedaCare Cancer Care - New London, New London

54981

RECRUITING

ThedaCare Cancer Care - Waupaca, Waupaca

55082

RECRUITING

Lakeview Hospital, Stillwater

55092

RECRUITING

Fairview Lakes Medical Center, Wyoming

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55109

RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

RECRUITING

Saint John's Hospital - Healtheast, Maplewood

55125

RECRUITING

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55362

RECRUITING

Monticello Cancer Center, Monticello

55369

RECRUITING

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55379

RECRUITING

Saint Francis Regional Medical Center, Shakopee

55387

RECRUITING

Ridgeview Medical Center, Waconia

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

RECRUITING

North Memorial Medical Health Center, Robbinsdale

55432

ACTIVE_NOT_RECRUITING

Unity Hospital, Fridley

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

56073

RECRUITING

New Ulm Medical Center, New Ulm

56201

RECRUITING

Rice Memorial Hospital, Willmar

60612

RECRUITING

John H Stroger Jr Hospital of Cook County, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

RECRUITING

OSF Saint Anthony's Health Center, Alton

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

62902

RECRUITING

Memorial Hospital of Carbondale, Carbondale

62918

RECRUITING

SIH Cancer Institute, Carterville

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Mercy Hospital Saint Louis, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64108

RECRUITING

University Health Truman Medical Center, Kansas City

64116

RECRUITING

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

64804

RECRUITING

Freeman Health System, Joplin

65109

SUSPENDED

MU Health Care Goldschmidt Cancer Center, Jefferson City

66044

RECRUITING

Lawrence Memorial Hospital, Lawrence

66061

RECRUITING

The University of Kansas Cancer Center - Olathe, Olathe

66205

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66606

RECRUITING

University of Kansas Health System Saint Francis Campus, Topeka

67401

RECRUITING

Salina Regional Health Center, Salina

67601

RECRUITING

HaysMed, Hays

67846

RECRUITING

Central Care Cancer Center - Garden City, Garden City

70065

RECRUITING

Ochsner Medical Center Kenner, Kenner

70072

RECRUITING

West Jefferson Medical Center, Marrero

70112

RECRUITING

University Medical Center New Orleans, New Orleans

70115

RECRUITING

Ochsner Baptist Medical Center, New Orleans

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

70360

RECRUITING

Terrebonne General Medical Center, Houma

70433

RECRUITING

Mary Bird Perkins Cancer Center - Covington, Covington

RECRUITING

Northshore Oncology Associates-Covington, Covington

RECRUITING

Ochsner Hematology Oncology North Shore - Covington (West Region), Covington

70503

RECRUITING

Cancer Center of Acadiana, Lafayette

70805

RECRUITING

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

RECRUITING

Our Lady of the Lake Physician Group, Baton Rouge

70809

RECRUITING

Louisiana Hematology Oncology Associates LLC, Baton Rouge

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

RECRUITING

MBP Cancer Center - Baton Rouge General, Baton Rouge

70816

RECRUITING

Medical Center of Baton Rouge, Baton Rouge

70817

RECRUITING

Louisiana Hematology Oncology Associates, Baton Rouge

RECRUITING

Our Lady of the Lake Medical Oncology, Baton Rouge

70836

RECRUITING

Ochsner High Grove, Baton Rouge

71103

RECRUITING

LSU Health Sciences Center at Shreveport, Shreveport

71202

RECRUITING

Ochsner LSU Health Monroe Medical Center, Monroe

71301

RECRUITING

Christus Saint Frances Cabrini Hospital, Alexandria

72401

RECRUITING

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro, Jonesboro

73120

RECRUITING

Mercy Hospital Oklahoma City, Oklahoma City

80026

RECRUITING

Kaiser Permanente-Rock Creek, Lafayette

80124

RECRUITING

Kaiser Permanente-Lone Tree, Lone Tree

80205

RECRUITING

Kaiser Permanente-Franklin, Denver

89052

RECRUITING

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

RECRUITING

OptumCare Cancer Care at Seven Hills, Henderson

89074

RECRUITING

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

RECRUITING

Urology Specialists of Nevada - Green Valley, Henderson

89102

RECRUITING

OptumCare Cancer Care at Charleston, Las Vegas

89113

RECRUITING

Urology Specialists of Nevada - Southwest, Las Vegas

89128

RECRUITING

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

RECRUITING

OptumCare Cancer Care at MountainView, Las Vegas

RECRUITING

Urology Specialists of Nevada - Northwest, Las Vegas

89135

RECRUITING

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

89144

RECRUITING

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

RECRUITING

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

RECRUITING

Summerlin Hospital Medical Center, Las Vegas

89148

RECRUITING

OptumCare Cancer Care at Fort Apache, Las Vegas

89169

RECRUITING

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

90027

RECRUITING

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90034

RECRUITING

Kaiser Permanente West Los Angeles, Los Angeles

90706

RECRUITING

Kaiser Permanente-Bellflower, Bellflower

90710

RECRUITING

Kaiser Permanente South Bay, Harbor City

91367

RECRUITING

Kaiser Permanente-Woodland Hills, Woodland Hills

91402

RECRUITING

Kaiser Permanente - Panorama City, Panorama City

91706

RECRUITING

Kaiser Permanente-Baldwin Park, Baldwin Park

91761

RECRUITING

Kaiser Permanente-Ontario, Ontario

92078

RECRUITING

Kaiser Permanente-San Marcos, San Marcos

92108

RECRUITING

Kaiser Permanente-San Diego Mission, San Diego

92120

RECRUITING

Kaiser Permanente-San Diego Zion, San Diego

92335

RECRUITING

Kaiser Permanente-Fontana, Fontana

92505

RECRUITING

Kaiser Permanente-Riverside, Riverside

92618

RECRUITING

Kaiser Permanente-Irvine, Irvine

92806

RECRUITING

Kaiser Permanente-Anaheim, Anaheim

93720

RECRUITING

Kaiser Permanente-Fresno, Fresno

94063

RECRUITING

Kaiser Permanente- Marshall Medical Offices, Redwood City

94080

RECRUITING

Kaiser Permanente-South San Francisco, South San Francisco

94115

RECRUITING

Kaiser Permanente-San Francisco, San Francisco

94531

RECRUITING

Kaiser Permanente-Deer Valley Medical Center, Antioch

94538

RECRUITING

Kaiser Permanente-Fremont, Fremont

94568

RECRUITING

Kaiser Permanente Dublin, Dublin

94577

RECRUITING

Kaiser Permanente San Leandro, San Leandro

94589

RECRUITING

Kaiser Permanente-Vallejo, Vallejo

94596

RECRUITING

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

94801

RECRUITING

Kaiser Permanente-Richmond, Richmond

94903

RECRUITING

Kaiser San Rafael-Gallinas, San Rafael

95051

RECRUITING

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

RECRUITING

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95210

RECRUITING

Kaiser Permanente-Stockton, Stockton

95356

RECRUITING

Kaiser Permanente-Modesto, Modesto

95403

RECRUITING

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

RECRUITING

Kaiser Permanente-Roseville, Roseville

95688

RECRUITING

Kaiser Permanente Medical Center-Vacaville, Vacaville

95814

RECRUITING

Kaiser Permanente Downtown Commons, Sacramento

95823

RECRUITING

Kaiser Permanente-South Sacramento, Sacramento

96819

RECRUITING

Kaiser Permanente Moanalua Medical Center, Honolulu

97132

RECRUITING

Providence Newberg Medical Center, Newberg

97213

RECRUITING

Providence Portland Medical Center, Portland

97225

RECRUITING

Providence Saint Vincent Medical Center, Portland

98055

RECRUITING

Valley Medical Center, Renton

29926-3827

RECRUITING

South Carolina Cancer Specialists PC, Hilton Head Island

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

University of Rochester NCORP Research Base

OTHER