Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock

PHASE4CompletedINTERVENTIONAL
Enrollment

85

Participants

Timeline

Start Date

December 2, 2019

Primary Completion Date

September 10, 2022

Study Completion Date

September 21, 2022

Conditions
Septic ShockSepticemiaIntraabdominal HypertensionRenal Injury
Interventions
DRUG

Vasopressor Agent

"Patients will receive vasopressor agents according to Surviving Sepsis Campaign Guidelines 2021"

DRUG

Crystalloid Solutions

"Patients will receive crystalloid solutions according to Surviving Sepsis Campaign Guidelines 2021"

PROCEDURE

Invasive Blood Pressure Monitoring

Invasive blood pressure monitoring will be performed through an intra-arterial cannula placed in the radial artery. Philips Intellivue mx 500 monitors will be used for bedside monitoring.

PROCEDURE

Intra-Abdominal Pressure Monitoring

"IAP will be measured indirectly by monitoring the pressure in the bladder.~Bladder pressure will be measured through an indwelling Foley catheter every twelve hours. Twenty-five mL of sterile normal saline will be injected in each measurement and readings will be recorded with a pressure transducer."

OTHER

Abdominal Perfusion Pressure

APP will be calculated with the following formula: (Mean arterial pressure) - (Intra-abdominal Pressure)

Trial Locations (1)

35100

UHS Izmir Bozyaka Education and Research Hospital, Izmir

All Listed Sponsors
lead

Bozyaka Training and Research Hospital

OTHER

NCT05358912 - Efficacy of Targeted Abdominal Perfusion Pressure in Septic Shock | Biotech Hunter | Biotech Hunter