120
Participants
Start Date
June 1, 2015
Primary Completion Date
January 15, 2016
Study Completion Date
February 22, 2016
Hypoxic-hyperoxic preconditioning
Patients were intubated and mechanically ventilated with the target values of PaO2 and PaCO2 (80 - 120 mm Hg and 35 - 45 mm Hg, respectively) under the inhalation anesthesia. HHP was carried out as follows: breathing with a hypoxic gas mixture for 10 min with the development of hypoxemia, then breathing with a hyperoxic gas mixture for 30 minutes, then a period of breathing with atmospheric air (normoxia and normocapnia) until the cardio-pulmonary bypass is connected.
Placebo
Patients were intubated and mechanically ventilated with the target values of PaO2 and PaCO2 (80 - 120 mm Hg and 35 - 45 mm Hg, respectively) under the inhalation anesthesia until the cardio-pulmonary bypass is connected.
Tomsk National Research Medical Center of the Russian Academy of Sciences
OTHER
Siberian State Medical University
OTHER
I.M. Sechenov First Moscow State Medical University
OTHER
Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
OTHER_GOV