511
Participants
Start Date
May 17, 2022
Primary Completion Date
July 30, 2025
Study Completion Date
December 30, 2026
HLX10
"Serplulimab is an innovative monoclonal antibody targeting PD-1,developed by Shanghai Henlius Biotech, Inc.~300mg Q3W"
carboplatin/cisplatin-etoposide
"Etoposide: 100 mg/m2, IV, on Days 1, 2, and 3 of each cycle. Carboplatin: AUC = 5, IV, on Day 1 of each cycle up to a dose of 750 mg. investigator's choice.~Cisplatin: 75mg/m2, IV, on Days 1 of each cycle. investigator's choice."
Thoracic radiotherapy
Standard Thoracic Radiotherapy
Placebo
Placebo Q3W
Prophylactic Cranial Irradiation (PCI)
PCI will be strongly recommended for participants who achieve CR or PR after completion of chemoradiation treatment.
Karl Landsteiner Institut für Lungenforschung und pneumologische Onkologie, c/o Klinik Floridsdorf Abteilung für Innere Medizin und Pneumologie, Vienna
Karl Landsteiner Institute for Lung Research and Pneumological Oncology, c/o Klinik Floridsdorf Department for Inner Medicine und Pneumology, Vienna
Pulmonary Institute of Torokbalint, Törökbálint
Hospital Universitario Puerta de Hierro, Madrid
Hospital St. Jansdal, Harderwijk
Hospital Universitario de Badajoz, Badajoz
Fejer County Szent Gyorgy University Teaching Hospital, Székesfehérvár
Isala Hospital, Zwolle
Hospital de la Santa Creu i Sant Pau, Barcelona
Hospital German Trias i Pujol/ ICO Badalona, Badalona
Klinikum Klagenfurt am Worthersee, Klagenfurt
Klinikum Klagenfurt am Wörthersee, Klagenfurt
Montefiore Medical Center, The Bronx
Northwell Health, Queens
New York City Health+HospitalsCorporation Elmhurst Hospital Center, Elmhurst
"General Hospital of Athens Alexandra", Athens
Hospital Universitario Reina Sofía, Córdoba
Innova Schar Cancer Insitute, Fairfax
University hospital Schleswig-Holstein, Travemünde
Hospital Gregorio Marañon, Madrid
Cancer Specialists of North Florida, Jacksonville
Mid Florida Hematology and Oncology Center, Orange City
Advent Health Orlando, Orlando
Napa Research, Pompano Beach
Hospital Marques de Valdecilla, Valdecilla
Hospital Quironsalud Sagrado Corazón, Seville
Tricounty Hematology and Oncology Associates, Massillon
Cleveland Clinic Mercy Hospital, Canton
Gabrail Cancer Center, Canton
University Hospital La Fe, Valencia
Kliniken der Stadt Cologne GmbH, Cologne
Health Partners, Bloomington
Kansas University Mediacal Center, Fairway
Tulane University, New Orleans
Pontchartrain Cancer Center, Covington
The University of Texas - Hope Cancer Center, Tyler
The Center for Cancer and Blood Disorders, Fort Worth
The University of Texas MD Anderson Cancer Center, Houston
Millennium Research & Clinical Development, Houston
Pro Research Tools, INC DBA Lumi Research, Kingwood
Lutheran Medical Center - Cancer Centers of Colorado, Golden
Renown Health, Reno
Southern California Permanente Group, Los Angeles
OPN-Los Alamitos, Los Alamitos
OPN-Glendale, Arcadia
Emad Ibrahim, MD, Inc, Redlands
Providence Medical Foundation, Santa Rosa
Kaiser Permanente Northwest, Portland
Northwest Medical Specialties, Tacoma
Cancer Hospital Chinese Academy of Medical Sciences, Beijing
Beijing Cancer Hospital, Beijing
Liaoning Cancer Hospital & Institute, Shenyang
Shenyang The Tenth People's Hospital, Shenyang
Jilin Cancer Hospital, Changchun
Harbin Medical University Cancer Hospital, Harbin
Jiamusi Cancer Hospital, Jiamusi
Shanghai Chest Hospital, Shanghai
Fudan University Shanghai Cancer Center, Shanghai
Zhongshan Hospital of Fudan University, Shanghai
Wenzhou University Hospital, Wenzhou
Northern Jiangsu people's Hospital, Yangzhou
Xuzhou Central Hospital, Xuzhou
Anhui Chest Hospital, Hefei
The First Affiliated Hospital of Bengbu Medical College, Bengbu
Qilu Hospital of Shandong University, Jinan
Shandong Cancer Hospital, Jinan
Affiliated Hospital of Qingdao University, Qingdao
Linyi Tumor Hospital, Linyi
Tianjin Medical University Cancer Institute & Hospital, Tianjin
Tianjin Medical University General Hospital, Tianjin
Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou
Yuhang Branch of the First Affiliated Hospital of Zhejiang University, Hangzhou
Zhejiang Cancer Hospital, Hangzhou
The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou
Taizhou Hospital of Zhejiang Province, Taizhou
The 1st Affiliated Hospital of WMU, Wenzhou
The First Affiliated Hospital of Nanchang University, Nanchang
First Affiliated Hospital of Gannan Medical University, Ganzhou
Ganzhou Cancer Hospital, Ganzhou
Fujian Cancer Hospital, Fuzhou
The First Affiliated Hospital of Chongqing Medical, Chongqing
Chongqing University Cancer Hospital, Chongqing
The Second Xiangya Hospita, Changsha
Hunan Cancer Hospital, Changsha
Xiangya Hospital Central South University, Changsha
The First People's Hospital Of Changde City, Changde
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan
Zhongnan hospital of wuhan university, Wuhan
Hubei Cancer Hospital, Wuhan
TaiHe Hospital Affiliated Hospital of Hubei University of Medicine, Shiyan
Henan Cancer Hospital, Zhengzhou
The First Affiliated Hospital of Zhengzhou University, Zhengzhou
The First Affiliated Hospital of Xinxiang Medical University, Xinxiang
The First Affiliated Hospital of Henan University of Science and Technology, Luoyang
The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou
Sun Yat-Sen University Cancer Center, Guangzhou
Gungzhouyikedaxuefushuzhongliuyiyuan, Guangzhou
Peking University Shenzhen Hospital, Shenzhen
Guangxi Medical University Cancer Hospital, Nanning
The Second Affiliated Hospital of Guilin Medical University, Guilin
University Hospital Ostrava (oncology department), Ostrava-Poruba
West China Hospital of Sichuan University, Chengdu
The Second People's Hospital Of Yibin, Sichuan
Yunnan Cancer Hospital, Kunming
First Affiliated Hospital of Xi'an Jiaotong University, Xi’an
Baoji Central Hospital, Baoji
Hong Kong United Oncology Centre, Hong Kong
Queen Elizabeth Hospital, Hong Kong
Queen Mary Hospital, Hong Kong
Eastern Connecticut Hematology & Oncology Associates, Norwich
Dartmouth Hitchcock Medical Center, Lebanon
Affiliated Hospital of Hebei University, Baoding
Cangzhou People's Hospital, Cangzhou
Tangshan People's Hospital, Tangshan
Shanxi Provincial Cancer Hospital, Taiyuan
University Hospital Brno (Clinic For Lung Diseases and Tuberculosis), Brno
University Hospital Brno, Brno
University Hospital Olomouc (Oncology Clinic), Olomouc
University Hospital Ostrava, Ostrava-Poruba
University Hospital Motol (Pneumology Clinic 2.LF UK and FN Motol), Prague
Nemocnice AGEL Ostrava-Vítkovice, Ostrava-Vitkovice
Nemocnice AGEL Ostrava-Vítkovice, Ostrava-Vítkovice
General University hospital in Prague (Oncology department), Prague
University Hospital Motol, Prague
"Sotiria Thoracic Diseases General Hospital of Athens", Athens
Riga East University Hospital, Latvian Oncology Center, Riga
Clinic of Oncology, Pauls Stradins Clinical university hospital, Riga
MedPoloniaSp. z o.o., Poznan
Lung and Chest Cancer Clinic, National Institute of Oncology, Warsaw
Shanghai Henlius Biotech
INDUSTRY