STOPS Trial: Total vs Subtotal Colectomy for Slow Transit Constipation

NARecruitingINTERVENTIONAL
Enrollment

252

Participants

Timeline

Start Date

March 27, 2022

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2028

Conditions
Slow Transit ConstipationSurgery
Interventions
PROCEDURE

Total colectomy with ileorectal anastomosis

Following complete colonic mobilization without preservation of the ileocolic vascular pedicle, the surgical specimen was extracted by extending the right lower quadrant trocar incision to approximately 4-5 cm. A resection of ileum, 2-3 cm proximal to the ileocecal junction, will be conducted by stapler. The anvil of a 29-mm circular stapler was inserted into the proximal ileal lumen and repositioned intra-abdominally. Ileorectal anastomosis was performed by transanal insertion of the circular stapler, aiming to achieve a tension-free, contamination-minimized reconstruction. Finally, a closed suction drain was placed in the rectouterine pouch (Douglas pouch), and all abdominal incisions were closed in layers.

PROCEDURE

Subtotal colectomy with cecal-rectal anastomosis

Following complete colonic mobilization with preservation of the ileocolic vascular pedicle and its branches, the surgical specimen was extracted by extending the right lower quadrant trocar incision to 4-5 cm. After insertion of the anvil from a 29-mm circular stapler through the ascending colon resection margin, a resection about 3 cm distal to the ileocecal junction will be conducted. The cecum was then positioned in the pelvis without rotational torsion, and an antiperistaltic cecorectal anastomosis was created between cecal fundus (after appendectomy) and the rectal stump. The anastomosis was performed via transanal insertion of the circular stapler to ensure tension-free, contamination-controlled reconstruction. Finally, a closed suction drain was placed in the rectouterine pouch (Douglas pouch), and all abdominal incisions were closed in a layered fashion.

Trial Locations (16)

110001

RECRUITING

The First Hospital of China Medical University, Shengyang

150007

WITHDRAWN

The First Affiliated Hospital of Harbin Medical University, Harbin

200127

RECRUITING

Renji Hospital, Shanghai Jiaotong University, Pudong

201299

RECRUITING

Shanghai Pudong New Area People's Hospital, Pudong

210002

RECRUITING

General Hospital of the Eastern Theater Cammand of the PLA, Nanjing

266011

RECRUITING

Qingdao Municipal Hospital, Qingdao

310014

RECRUITING

Zhejiang Provincial People's Hospital, Hangzhou

400042

RECRUITING

Army Medical Center (Daping Hospital), Yuzhong

430060

RECRUITING

Renmin Hospital of Wuhan University, Wuhan

430062

RECRUITING

Zhongnan Hospital of Wuhan University, Wuhan

530016

WITHDRAWN

The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning

610017

RECRUITING

Chengdu Analrectal Hospital, Chengdu

610036

RECRUITING

The General Hospital of Western Theater Command, Chengdu

644000

RECRUITING

The Second People's Hospital of Yibin, Yibin

710032

RECRUITING

Xijing Hospital, Xi’an

730050

RECRUITING

No. 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou

All Listed Sponsors
lead

Third Military Medical University

OTHER