Genotype-guided Treatment in DLBCL

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,100

Participants

Timeline

Start Date

June 1, 2022

Primary Completion Date

June 1, 2026

Study Completion Date

June 1, 2026

Conditions
Diffuse Large B Cell Lymphoma
Interventions
DRUG

Rituximab

Rituximab IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Cyclophosphamide

Cyclophosphamide IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Doxorubicin

Doxorubicin IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Vincristine

Vincristine IV infusion will be administered as per the schedule specified in the respective arm.

DRUG

Prednisone

Prednisone PO will be administered as per the schedule specified in the respective arm.

DRUG

Orelabrutinib

Orelabrutinib PO will be administered as per the schedule specified in the respective arm.

DRUG

Lenalidomide

Lenalidomide PO will be administered as per the schedule specified in the respective arm.

DRUG

Decitabine

Decitabine IV infusion will be administered as per the schedule specified in the respective arm.

Trial Locations (1)

200025

RECRUITING

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai

All Listed Sponsors
collaborator

West China Hospital, Sichuan

UNKNOWN

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

OTHER

collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

The Second Hospital of Anhui Medical University

OTHER

collaborator

Zhongda Hospital

OTHER

collaborator

The First Affiliated Hospital of Soochow University

OTHER

collaborator

China-Japan Friendship Hospital

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

Beijing Hospital

OTHER_GOV

collaborator

The Second Affiliated Hospital of Dalian Medical University

OTHER

collaborator

Zhujiang Hospital

OTHER

collaborator

The First Affiliated Hospital of Anhui Medical University North District

UNKNOWN

collaborator

Hunan Cancer Hospital

OTHER

collaborator

Liaoning Cancer Hospital & Institute

OTHER

collaborator

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

OTHER

collaborator

Cancer Hospital Affiliated to Xinjiang Medical University

UNKNOWN

collaborator

The First Affiliated Hospital of Xiamen University

OTHER

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

collaborator

LanZhou University

OTHER

collaborator

Central South University

OTHER

collaborator

The Affiliated Hospital of Xuzhou Medical University

OTHER

collaborator

Yunnan Cancer Hospital

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Fujian Medical University Union Hospital

OTHER

collaborator

The First Hospital of Jilin University

OTHER

collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

collaborator

Gansu Cancer Hospital

OTHER

collaborator

The First Affiliated Hospital of University of Science and Technology of China

OTHER

collaborator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

Second Affiliated Hospital of Xi'an Jiaotong University

OTHER

collaborator

First Affiliated Hospital Xi'an Jiaotong University

OTHER

collaborator

RenJi Hospital

OTHER

collaborator

Shandong Cancer Hospital and Institute

OTHER

collaborator

Affiliated Cancer Hospital of Harbin Medical University

UNKNOWN

collaborator

First Affiliated Hospital of Chongqing Medical University

OTHER

collaborator

Fudan University

OTHER

collaborator

Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences and Pekcing Union Medical College

UNKNOWN

collaborator

Affiliated Hospital of Nantong University

OTHER

collaborator

Yunnan First People's Hospital

UNKNOWN

collaborator

Shanxi Province Cancer Hospital

OTHER

collaborator

Fifth Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Beijing Tongren Hospital

OTHER

collaborator

First Affiliated Hospital of Harbin Medical University

OTHER

collaborator

The Third Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Harbin Institute of Hematology

UNKNOWN

collaborator

The First Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Affiliated Hospital of Guilin Medical College

UNKNOWN

collaborator

Air Force Military Medical University, China

OTHER

collaborator

Affiliated Zhongshan Hospital of Dalian University

OTHER

collaborator

Yantai Yuhuangding Hospital

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Peking University Third Hospital

OTHER

lead

Ruijin Hospital

OTHER