Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery

NACompletedINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

April 6, 2021

Primary Completion Date

January 27, 2022

Study Completion Date

April 30, 2022

Conditions
Postoperative Cognitive Dysfunction
Interventions
PROCEDURE

Thoracic paravertebral block

"The patient was placed in lateral supine position, and the T5 spinous process was moved 2 to 3cm laterally to the operative side as the puncture point, and the pleura and T5 transverse process were observed, and the paraspinal space was observed on the lower lateral side of the transverse process. Using in-plane technique, the needle position was adjusted under ultrasound visualization to reach the paraspinal space. 20ml 0.375% ropivacaine was injected into the suction syringe when there was no blood or gas, and the drug liquid could be seen spreading outside the pleura. Landscape sign appeared, indicating successful block"

DRUG

Esketamine

Group TE received s-ketamine anesthesia induction dose of 0.3 mg/kg on the basis of TA group. Anesthesia maintenance dose of 0.2ug/kg/h was pumped to 30min before the end of the operation

BEHAVIORAL

Measurement of cognitive function

Patients undergoing thoracoscopic surgery underwent general anesthesia.MMSE was assessed at one day before surgery, one day after surgery, and three months after surgery

BEHAVIORAL

The assessment of cognitive function

Participants were assessed for MMSE at the same period as the group C

Trial Locations (1)

Unknown

The First hosptial of Qinhuangdao, Qinhuangdao

All Listed Sponsors
lead

The First Hospital of Qinhuangdao

OTHER_GOV

NCT05341375 - Effects of Thoracic Paravertebral Block Combined With S-ketamine on Postoperative Pain and Cognitive Function After Thoracoscopic Surgery | Biotech Hunter | Biotech Hunter