HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

586

Participants

Timeline

Start Date

July 8, 2022

Primary Completion Date

May 31, 2024

Study Completion Date

June 30, 2026

Conditions
Nonsquamous Non-small Cell Lung CancerEGFR L858REGFR Exon 19 Deletion
Interventions
DRUG

Patritumab Deruxtecan

Intravenous administration, 5.6 mg/kg every 3 weeks (q3W)

DRUG

Platinum-based chemotherapy

Intravenous, pemetrexed 500 mg/m\^2 plus either cisplatin (75 mg/m\^2) or carboplatin (target area under the plasma concentration time curve of 5 \[AUC5\] by using the Calvert formula) q3W

Trial Locations (182)

100

National Taiwan University Hospital NTUH, Taipei

333

Chang Gung Memorial Hospital-Linkou Branch, Taoyuan District

704

National Cheng Kung University Hospital NCKUH, Tainan City

824

E-Da Hospital, Kaohsiung City

1200

Cliniques Universitaires Saint-Luc, Brussels

1210

Karl Landsteiner Institut fur Lungenforschung und pneumologische Onkologie c/o Klinik Floridsdorf, Vienna

1478

Akershus University Hospital, Nordbyhagen

2050

The Chris O'Brien Lifehouse, Camperdown

2170

Liverpool Hospital, Liverpool

2217

St George Public Hospital, Kogarah

2800

AZ Sint Maarten Mechelen, Mechelen

3000

UZ Leuven, Leuven

3084

Austin Hospital, Melbourne

4102

Princess Alexandra Hospital, Woolloongabba

4600

Klinikum Wels-Grieskirchen, Wels

6008

St John of God Subiaco Hospital, Subiaco

6020

Medizinische Universitaet Innsbruck, Innsbruck

6800

Landeskrankenhaus Feldkirch, Feldkirch

7000

Kantonsspital Graubuenden - Hauptstandort, Chur

8100

Stavanger University Hospital, Stavanger

8400

Kantonsspital Winterthur KSW, Winterthur

8800

AZ Delta, Roeselare

9020

Klinikum Klagenfurt Pulmologie, Klagenfurt

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano

10065

Memorial Sloan Kettering Cancer Center, New York

10323

National Cancer Center, Goyang

10467

Montefiore Medical Center, The Bronx

11217

Taipei Veterans General Hospital, Taipei

14076

Centre Francois Baclesse, Caen

15006

Hospital Teresa Herrera C.H.U.A.C., A Coruña

20089

IRCCS Humanitas Research Hospital, Rozzano

20141

IRCCS Istituto Europeo di Oncologia, Milan

20162

Asst Grande Ospedale Metropolitano Niguarda, Milan

20817

American Oncology Partners of Maryland, Bethesda

21100

ASST Sette Laghi, Varese

22031

Inova Schar Cancer Institute, Fairfax

Virginia Cancer Specialists, Fairfax

22927

LungenClinic Grosshansdorf, Großhansdorf

26121

Pius-Hospital Oldenburg, Oldenburg

28007

Hospital General Universitario Gregorio Maranon, Madrid

28033

MD Anderson Cancer Center, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Regional Universitario Malaga, Málaga

29609

Hopital Morvan CHU de Brest, Brest

30322

Emory University, Atlanta

33980

Sarah Cannon/Florida Cancer Specialists - FCS South, Port Charlotte

34298

Montpellier Cancer Institute ICM, Montpellier

34376

LKI Lungenfachklinik Immenhausen, Immenhausen

35000

Centre Hospitalier Universitaire (CHU) de Rennes - Hopital de Pontchaillou, Rennes

35016

Complejo Hospitalario Materno-Insular - Hospital Insular de Gran Canaria, Las Palmas de Gran Canaria

35392

Universitatsklinik Giessen und Marburg, Giessen

37203

Sarah Cannon Research Institute, Nashville

39120

Hospital Univeritario Marques de Valdecilla, Santander

40705

Taichung Veterans General Hospital, Taichung

41009

Hospital Universitario Virgen Macarena, Seville

41071

Hospital Universitario Virgen Macarena, Seville

43126

Azienda Ospedaliero Universitaria di Parma, Parma

44805

Institut de Cancrologie de lOuest ICO, Saint-Herblain

45147

Universitaetsklinikum Essen, Essen

53792

University of Wisconsin Carbone Cancer Center, Madison

55100

Ospedale San Luca, Lucca

60488

IKF Krankenhaus Nordwest, Frankfurt am Main

66100

University G. D'Annunzio Chieti, Chieti

69008

Centre Leon Berard, Lyon

69126

Thoraxklinik Heidelberg gGmbH, Heidelberg

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70124

IRCCS Istituto Oncologico Giovanni Paolo II, Bari

72762

Highlands Oncology, Springdale

73730

Klinikum Esslingen GmbH, Esslingen am Neckar

75005

Institut Curie, Paris

75010

APHP - Hopital Saint Louis, Paris

75235

University of Texas Southwestern Medical Center, Dallas

82131

Asklepios Fachklinik Muenchen-Gauting, Gauting

83712

St Luke's Cancer Institute, Boise

87439

Klinikverbund Allgaeu, Kempten

90033

USC Norris Comprehensive Cancer Center, Los Angeles

90603

Innovative Clinical Research Institute, Whittier

91010

City of Hope, Duarte

92037

Moores Cancer Center at the UC San Diego Health, La Jolla

Scripps MD Anderson Cancer Center, La Jolla

94589

Kaiser Permanente - Vallejo Medical Center, Vallejo

94805

Gustave Roussy, Villejuif

97213

Providence Portland Medical Center, Portland

99508

Alaska Oncology and Hematology LLC, Anchorage

100142

Peking University Cancer Hospital, Beijing

100191

Pecking University Third Hospital, Haidian

110001

The First Hospital of China Medical University, Shenyang

119074

National University Cancer Institute National University Hospital, Singapore

130021

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University - Tumor Hospital The Third Affiliated Hospital, Harbin

169610

National Cancer Centre Singapore NCCS, Singapore

200032

Fudan University - Shanghai Cancer Center FUSCC, Shanghai

210002

General Hospital of Eastern Theater Command, Nanjing

230022

The First Affiliated Hospital - Anhui Medical University Dept of Medical Oncology, Hefei

276000

Lin Yi Cancer Hospital, Linyi

308433

Tan Tock Seng Hospital, Singapore

310003

The First Affiliated Hospital of College of Medicine Zhejiang University, Hangzhou

310022

Zhejiang Cancer hospital, Hangzhou

329563

ICON Cancer Centre, Singapore

350001

Fujian Medical University - Union Hospital Foochow Christian Union Hospital, Fuzhou

410013

Hunan Cancer Hospital, Changsha

430022

Union Hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan

430030

Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital TJH, Wuhan

450003

Henan Provincial Peoples Hospital, Henan

450008

Henan Cancer Hospital, Zhengzhou

510080

Guangdong Academy of Medical Science (GAMS) - Guangdong Provincial Peoples Hospital, Guangzhou

The First Affiliated Hospital Sun-Yat-Sen University, Guangzhou

515041

Cancer Hospital of Shantou University Medical College, Shantou

530021

The First Affiliated Hospital of Guangxi Medical University, Nanning

610041

University of Electronic Science Technology of China UESTC - Sichuan Cancer Hospital Institute Sichuan Provincial Tumor Hospital, Chengdu

650033

The Second Affiliated Hospital of Kunming Medical University, Kunming

710061

The First Affiliate Hospital of Xi'an Jiaotong University, Xi'an

830000

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

999077

Prince of Wales Hospital, Hong Kong

University of Hong Kong/Queen Mary Hospital, Hong Kong

02215

Dana-Farber Cancer Institute, Boston

03756

Dartmouth Hitchcock Medical Center, Lebanon

08050

Hackensack Meridian Health-Southern Ocean Medical Center, Manahawkin

L6R 3J7

William Osler Health System - Brampton Civic Hospital, Brampton

260-0013

National Cancer Center Hospital East, Chibi

14076 CEDEX 05

Centre Francois Baclesse, Caen

00852

Pamela Youde Nethersole Eastern Hospital, Hong Kong

Unknown

Queen Elizabeth Hospital, Hong Kong

06132

Ospedale Santa Maria della Misericordia, Perugia

00144

IFO Regina Elena, Roma

673-8558

Hyogo Cancer Center, Akashi

812-8582

Kyushu University Hospital, Fukuoka

350-1298

Saitama Medical University International Medical Center, Hidaka

573-1191

Kansai Medical University Hospital, Hirakata

740-8510

Iwakuni Clinical Center, Iwakuni

594-0073

Izumi City General Hospital, Izumi

920-8641

Kanazawa University Hospital, Kanazawa

135-8550

The Cancer Institute Hospital of JFCR, Kōtoku

861- 4193

Saiseikai Kumamoto Hospital, Kumamoto

710-8602

Kurashiki Central Hospital, Kurashiki

830-0011

Kurume University Hospital, Kurume

515-8544

Matsusaka Municipal Hospital, Matsusaka

791-0280

NHO Shikoku Cancer Center, Matsuyama

460-0001

National Hospital Organization Nagoya Medical Center, Nagoya

951-8566

Niigata Cancer Center Hospital, Niigata

700-8558

Okayama University Hospital, Okayama

589-8511

Kindai University Hospital, Ōsaka-sayama

003-0804

National Hospital Organization Hokkaido Cancer Center, Sapporo

980-0873

Sendai Kousei Hospital, Sendai

113-8677

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo

470-1192

Fujita Health University Hospital, Toyoake

641-8509

Wakayama Medical University Hospital, Wakayama

1066 CX

Netherlands Cancer Institute, Amsterdam

6815 AD

Rijnstate Ziekenhuis, Arnhem

3844 DG

St. Jansdal Ziekenhuis, Harderwijk

2333ZA

Leiden University Medical Center, Leiden

3015 CD

Erasmus MC, Rotterdam

3584 CX

University Medical Center Utrecht, Utrecht

0379

Oslo University Hospital-The Norwegian Radium Hospital, Oslo

15-450

II Klinika Chorob Pluc i Gruzlicy, Bialystok

20-250

Onko-Centrum Sp. z o.o., Lublin

60-693

Med Polonia Sp. z o.o., Poznan

1400-038

Centro Clinico Champalimaud, Lisbon

1908-072

Instituto Portugues de Oncologio de Lisboa, Lisbon

4099-001

Centro Hospitalar Universitario do Porto - Hospital de Santo Antonio, Porto

4434-502

Centro Hospitalar de Vila Nova de Gaia - Espinho, Porto

463-707

Seoul National University Bundang Hospital, Seongnam

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital, Seoul

135-710

Samsung Medical Center, Seoul

08003

Hospital del Mar, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clinic i Provincial de Barcelona, Barcelona

B9 5SS

University Hospital Birmingham NHS Trust, Birmingham

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

LS9 7TF

Leeds Cancer Centre, Leeds

LE15WW

University Hospitals of Leicester, Leicester

EC1A 7BE

Barts and The London NHS Trust - St Bartholomew s hospital - PET CT Centre, London

SW3 6JJ

The Royal Marsden Hospital NHS Foundation Trust, London

The Royal Marsden NHS Foundation Trust, London

M20 4BX

The Christie Hospital, Manchester

WV10 0QP

The Royal Wolverhampton NHS Trust, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY

NCT05338970 - HERTHENA-Lung02: A Study of Patritumab Deruxtecan Versus Platinum-based Chemotherapy in Metastatic or Locally Advanced EGFRm NSCLC After Failure of EGFR TKI Therapy | Biotech Hunter | Biotech Hunter