A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).

PHASE3RecruitingINTERVENTIONAL
Enrollment

406

Participants

Timeline

Start Date

April 7, 2021

Primary Completion Date

March 31, 2031

Study Completion Date

March 31, 2031

Conditions
Oligodendroglioma
Interventions
DRUG

CETEG

At progression, patients without prior radiotherapy will undergo radiotherapy and PCV as an adjunct chemotherapy if bone marrow reserve allows in the experimental arm.

DRUG

PCV

In the comparator arm there is the option for second radiotherapy or even reuse of the full radiochemotherapy regimen as it had been given at diagnosis (BIC).

RADIATION

RT

Radiotherapy at 50.4/54 Gy in 1.8 Gy fractions for grade 2 and 59.4 Gy in 1.8 Gy fractions for grade 3 gliomas

Trial Locations (19)

10117

RECRUITING

Charité, University Medicine Berlin, Neurosurgery, Berlin

19049

RECRUITING

Helios Hospital Schwerin, Neurosurgery, Schwerin

32429

RECRUITING

University Clinic Muehlenkreis, Minden, Minden

37075

RECRUITING

University Hospital Göttingen, Neurosurgery, Göttingen

40225

RECRUITING

University Hospital Duesseldorf, Neurooncology, Düsseldorf

44892

RECRUITING

Knappschaftskrankenhaus Bochum GmbH, Neurology Clinic, Bochum

50937

RECRUITING

University Hospital Cologne, Neurosurgery, Cologne

53127

RECRUITING

University Hospital Bonn, Neurology Clinic, Bonn

60528

RECRUITING

University Hospital Frankfurt, Neurooncology, Frankfurt

66421

RECRUITING

University Hospital Saarland, Neurosurgery, Homburg

68167

RECRUITING

University Hospital Mannheim, Neurology Clinic, Mannheim

69120

RECRUITING

University Hospital Heidelberg, Department of Neurooncology, Heidelberg

72076

RECRUITING

University Hospital Tuebingen, Neurooncology, Tübingen

81675

RECRUITING

University Hospital rechts der Isar, Radiation Oncology, Munich

93053

RECRUITING

University Hospital Regensburg, Neurology Clinic, Regensburg

97080

RECRUITING

University Hospital Wuerzburg, Neurosurgery, Würzburg

09116

RECRUITING

Chemnitz Hospital, Neurosurgery, Chemnitz

07747

RECRUITING

University Hospital of Jena, Neurosurgery, Jena

04103

RECRUITING

University Hospital Leipzig, Radiation Therapy, Leipzig

All Listed Sponsors
collaborator

Universitätsmedizin Mannheim

OTHER

collaborator

Ruhr University of Bochum

OTHER

lead

University Hospital Heidelberg

OTHER

NCT05331521 - A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas). | Biotech Hunter | Biotech Hunter