A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

770

Participants

Timeline

Start Date

April 28, 2022

Primary Completion Date

July 14, 2025

Study Completion Date

July 14, 2025

Conditions
Colorectal Neoplasms
Interventions
DRUG

Nivolumab-relatlimab FDC

Specified dose on specified days

DRUG

Regorafenib

Specified dose on specified days

DRUG

TAS-102

Specified dose on specified days

Trial Locations (139)

100

Local Institution - 0121, Zhongzheng

500

Local Institution - 0128, Changhua

704

Local Institution - 0076, Tainan City

1200

Local Institution - 0062, Woluwé-Saint-Lambert

1425

Local Institution - 0022, Ciudad Autónoma Buenos Aires

1834

Local Institution - 0024, Ciudad Autónoma Buenos Aires

2145

Local Institution - 0114, Westmead

2650

Local Institution - 0098, Wagga Wagga

Local Institution - 0070, Edegem

3000

Local Institution - 0120, Leuven

3010

Local Institution - 0069, Bern

3084

Local Institution - 0021, Melbourne

3168

Local Institution - 0010, Clayton

4120

Local Institution - 0001, Greenslopes

5000

Local Institution - 0057, Aarau

5020

Local Institution - 0131, Salzburg

6150

Local Institution - 0027, Murdoch

6800

Local Institution - 0030, Graz

8500

Local Institution - 0023, Río Grande

9000

Local Institution - 0068, Ghent

9020

Local Institution - 0078, Klagenfurt

10408

Local Institution - 0073, Goyang-si, Gyeonggi-do

13353

Local Institution - 0055, Berlin

13620

Local Institution - 0129, Seongnamsi Bundanggu

14000

Local Institution - 0017, Caen

15006

Local Institution - 0112, A Coruña

16132

Local Institution - 0091, Genova

20133

Local Institution - 0045, Milan

20162

Local Institution - 0046, Milan

20249

Local Institution - 0040, Hamburg

21000

Local Institution - 0090, Dijon

23284

Local Institution - 0132, Richmond

26801

Local Institution - 0099, Hořovice

27710

Local Institution - 0009, Durham

28041

Local Institution - 0102, Madrid

28046

Local Institution - 0113, Madrid

29414

Local Institution - 0008, Charleston

30342

Local Institution - 0031, Atlanta

33000

Local Institution - 0066, Bordeaux

33176

Local Institution - 0025, Miami

35128

Local Institution - 0148, Padua

41013

Local Institution - 0035, Seville

42123

Local Institution - 0059, Reggio Emilia

45147

Local Institution - 0101, Essen

45220

Local Institution - 0082, Cincinnati

46805

Local Institution - 0081, Fort Wayne

50009

Local Institution - 0116, Zaragoza

57104

Local Institution - 0096, Sioux Falls

60488

Local Institution - 0041, Frankfurt A. Main

68167

Local Institution - 0054, Mannheim

69008

Local Institution - 0036, Lyon

70403

Local Institution - 0077, Tainan City

72764

Local Institution - 0056, Reutlingen

75012

Local Institution - 0089, Paris

80131

Local Institution - 0115, Napoli

80138

Local Institution - 0061, Napoli

81377

Local Institution - 0034, München

83301

Local Institution - 0111, Kaohsiung City

92151

Local Institution - 0039, Suresnes

92300

Local Institution - 0020, Levallois-Perret

95122

Local Institution - 0060, Catania

97080

Local Institution - 0053, Würzburg

100142

Local Institution - 0122, Beijing

110042

Local Institution - 0149, Shenyang

169610

Local Institution - 0109, Singapore

200032

Local Institution - 0153, Shanghai

210008

Local Institution - 0143, Nanjing

223300

Local Institution - 0146, Huaian

250117

Local Institution - 0142, Jinan

300121

Local Institution - 0150, Tianjin

310003

Local Institution - 0139, Hangzhou

310022

Local Institution - 0160, Hangzhou

329563

Local Institution - 0087, Singapore

400030

Local Institution - 0134, Chongqing

410013

Local Institution - 0138, Changsha

Local Institution - 0158, Changsha

430071

Local Institution - 0126, Wuhan

430079

Local Institution - 0164, Wuhan

510655

Local Institution - 0151, Guangzhou

610041

Local Institution - 0144, Chengdu

710038

Local Institution - 0152, Xi'an

5418567

Local Institution - 0110, Osaka

7560908

Local Institution - 0015, Santiago

8380456

Local Institution - 0033, Santiago

72762-5328

Local Institution - 0044, Springdale

90089-0112

Local Institution - 0012, Los Angeles

06360-2753

Local Institution - 0117, Norwich

83712-6267

Local Institution - 0071, Boise

02214

Massachusetts General Hospital,, Boston

48109-1382

Local Institution - 0042, Ann Arbor

08816-3340

Local Institution - 0043, East Brunswick

43210-1240

Local Institution - 0095, Columbus

19111-2434

Local Institution - 0147, Philadelphia

37203-2173

Local Institution - 0127, Nashville

76104-4611

Local Institution - 0097, Fort Worth

53705-2275

Local Institution - 0005, Madison

C1181ACH

Local Institution - 0026, Ciudad Autónoma Buenos Aires

T6G 1Z2

Local Institution - 0003, Edmonton

K1H 8L6

Local Institution - 0014, Ottawa

M5G 2M9

Local Institution - 0007, Toronto

H2X 3E4

Local Institution - 0019, Montreal

H4A 3J1

Local Institution - 0104, Montreal

J1H 5N4

Local Institution - 0004, Sherbrooke

030013

Local Institution - 0141, Taiyuan

500 05

Local Institution - 0016, Hradec Králové

775 20

Local Institution - 0100, Olomouc

708 52

Local Institution - 0123, Ostrava

150 06

Local Institution - 0064, Prague

260-8717

Local Institution - 0107, Chiba

104-0045

Local Institution - 0103, Chūōku

350-1298

Local Institution - 0105, Hidaka-shi

309-1793

Local Institution - 0154, Kasama-Shi

277-8577

Local Institution - 0084, Kashiwa-Shi

216-8511

Local Institution - 0086, Kawasaki-Shi

362-0806

Local Institution - 0119, Kitaadachi-gun

135-8550

Local Institution - 0108, Kōtoku

791-0280

Local Institution - 0118, Matsuyama

060-8648

Local Institution - 0088, Sapporo

565-0871

Local Institution - 0083, Suita-Shi

411-8777

Local Institution - 0085, Sunto-gun

241-8515

Local Institution - 0124, Yokohama

1066 CX

Local Institution - 0050, Amsterdam

02-507

Local Institution - 0051, Warsaw

05-400

Local Institution - 0037, Warsaw

30-727

Local Institution - 0018, Krakow

02-781

Local Institution - 0052, Warsaw

00927

Local Institution - 0106, San Juan

03722

Local Institution - 0072, Seoul

05505

Local Institution - 0092, Seoul

06351

Local Institution - 0075, Seoul

110-744

Local Institution - 0074, Seoul

08916

Local Institution - 0029, Badalona

08036

Local Institution - 0093, Barcelona

08035

Local Institution - 0080, Barcelona

112 81

Local Institution - 0038, Stockholm

171 76

Local Institution - 0135, Stockholm

751 85

Local Institution - 0058, Uppsala

413 45

Local Institution - 0067, Gothenburg

214 28

Local Institution - 0094, Malmo

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT05328908 - A Study of Nivolumab-relatlimab Fixed-dose Combination Versus Regorafenib or TAS-102 in Participants With Later-lines of Metastatic Colorectal Cancer | Biotech Hunter | Biotech Hunter