Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

February 1, 2023

Primary Completion Date

June 15, 2028

Study Completion Date

June 15, 2028

Conditions
Metastatic Renal Cell CarcinomaStage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Unresectable Renal Cell Carcinoma
Interventions
BIOLOGICAL

Avelumab

Given IV

DRUG

Axitinib

Given PO

PROCEDURE

Biospecimen Collection

Undergo collection of blood

PROCEDURE

Bone Scan

Undergo bone scan

DRUG

Cabozantinib

Given PO

PROCEDURE

Computed Tomography

Undergo CT

BIOLOGICAL

Ipilimumab

Given IV

DRUG

Lenvatinib

Given PO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

BIOLOGICAL

Nivolumab

Given IV

BIOLOGICAL

Pembrolizumab

Given IV

RADIATION

Stereotactic Ablative Radiotherapy

42 Gy in 3 fractions

Trial Locations (258)

6

RECRUITING

Saint Lukes Hospital, Dublin

18

RECRUITING

Beacon Hospital, Dublin

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10604

RECRUITING

Memorial Sloan Kettering Westchester, Harrison

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

11725

RECRUITING

Memorial Sloan Kettering Commack, Commack

11794

ACTIVE_NOT_RECRUITING

Stony Brook University Medical Center, Stony Brook

12801

RECRUITING

Glens Falls Hospital, Glens Falls

15009

RECRUITING

UPMC-Heritage Valley Health System Beaver, Beaver

15213

RECRUITING

UPMC-Magee Womens Hospital, Pittsburgh

15215

RECRUITING

UPMC-Saint Margaret, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

RECRUITING

UPMC-Shadyside Hospital, Pittsburgh

15237

RECRUITING

UPMC-Passavant Hospital, Pittsburgh

15243

RECRUITING

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh

15601

RECRUITING

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg

16105

RECRUITING

UPMC Hillman Cancer Center - New Castle, New Castle

16505

RECRUITING

UPMC Hillman Cancer Center Erie, Erie

17015

RECRUITING

Carlisle Regional Cancer Center, Carlisle

17050

RECRUITING

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg

17109

RECRUITING

UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg

17408

RECRUITING

UPMC Memorial, York

17754

RECRUITING

Divine Providence Hospital, Williamsport

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

19611

RECRUITING

Reading Hospital, West Reading

21044

ACTIVE_NOT_RECRUITING

Central Maryland Radiation Oncology in Howard County, Columbia

21061

ACTIVE_NOT_RECRUITING

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie

21201

ACTIVE_NOT_RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

23114

RECRUITING

Bon Secours Saint Francis Medical Center, Midlothian

23230

RECRUITING

Bon Secours Cancer Institute at Reynolds Crossing, Richmond

25304

RECRUITING

West Virginia University Charleston Division, Charleston

25701

RECRUITING

Edwards Comprehensive Cancer Center, Huntington

27012

RECRUITING

Wake Forest University at Clemmons, Clemmons

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27262

RECRUITING

Hayworth Cancer Center, High Point

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

RECRUITING

Duke University Medical Center, Durham

28025

RECRUITING

Atrium Health Cabarrus/LCI-Concord, Concord

28054

RECRUITING

Levine Cancer Institute-Gaston, Gastonia

28112

RECRUITING

Atrium Health Union/LCI-Union, Monroe

28203

RECRUITING

Carolinas Medical Center/Levine Cancer Institute, Charlotte

28210

RECRUITING

Atrium Health Pineville/LCI-Pineville, Charlotte

28262

RECRUITING

Atrium Health University City/LCI-University, Charlotte

28277

RECRUITING

Levine Cancer Institute-Ballantyne, Charlotte

28659

RECRUITING

Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro

29425

RECRUITING

Medical University of South Carolina, Charleston

29646

RECRUITING

Self Regional Healthcare, Greenwood

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33028

RECRUITING

Memorial Hospital West, Pembroke Pines

33140

RECRUITING

Mount Sinai Medical Center, Miami Beach

33176

RECRUITING

Miami Cancer Institute, Miami

33180

RECRUITING

Mount Sinai Comprehensive Cancer Center at Aventura, Aventura

35233

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

44011

RECRUITING

UH Seidman Cancer Center at UH Avon Health Center, Avon

44060

RECRUITING

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

RECRUITING

Case Western Reserve University, Cleveland

44122

RECRUITING

UHHS-Chagrin Highlands Medical Center, Beachwood

44129

RECRUITING

University Hospitals Parma Medical Center, Parma

44266

RECRUITING

University Hospitals Portage Medical Center, Ravenna

45005

RECRUITING

Dayton Physicians LLC-Atrium, Franklin

45069

RECRUITING

University of Cincinnati Cancer Center-West Chester, West Chester

45219

RECRUITING

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

45415

RECRUITING

Dayton Physician LLC - Englewood, Dayton

RECRUITING

Miami Valley Hospital North, Dayton

45459

RECRUITING

Dayton Physicians LLC-Miami Valley South, Centerville

RECRUITING

Miami Valley Hospital South, Centerville

48073

RECRUITING

Corewell Health William Beaumont University Hospital, Royal Oak

48085

RECRUITING

Corewell Health Beaumont Troy Hospital, Troy

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48124

RECRUITING

Corewell Health Dearborn Hospital, Dearborn

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48336

RECRUITING

Corewell Health Farmington Hills Hospital, Farmington Hills

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

50010

RECRUITING

Mary Greeley Medical Center, Ames

RECRUITING

McFarland Clinic - Ames, Ames

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

53051

RECRUITING

Froedtert Menomonee Falls Hospital, Menomonee Falls

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

53095

RECRUITING

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53154

RECRUITING

Drexel Town Square Health Center, Oak Creek

53188

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

54401

RECRUITING

Aspirus Regional Cancer Center, Wausau

54409

RECRUITING

Langlade Hospital and Cancer Center, Antigo

54449

RECRUITING

Marshfield Medical Center-Marshfield, Marshfield

54456

ACTIVE_NOT_RECRUITING

Marshfield Medical Center - Neillsville, Neillsville

54476

RECRUITING

Marshfield Medical Center - Weston, Weston

54481

RECRUITING

Aspirus Cancer Care - Stevens Point, Stevens Point

54482

RECRUITING

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

RECRUITING

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

ACTIVE_NOT_RECRUITING

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54501

RECRUITING

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander

54548

RECRUITING

Marshfield Medical Center - Minocqua, Minocqua

54701

RECRUITING

Marshfield Medical Center-EC Cancer Center, Eau Claire

54801

RECRUITING

Essentia Health-Spooner Clinic, Spooner

54806

RECRUITING

Duluth Clinic Ashland, Ashland

RECRUITING

Northwest Wisconsin Cancer Center, Ashland

54843

RECRUITING

Essentia Health-Hayward Clinic, Hayward

54848

ACTIVE_NOT_RECRUITING

Marshfield Medical Center - Ladysmith, Ladysmith

54868

RECRUITING

Marshfield Medical Center-Rice Lake, Rice Lake

54880

RECRUITING

Essentia Health Saint Mary's Hospital - Superior, Superior

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55082

RECRUITING

Lakeview Hospital, Stillwater

55101

RECRUITING

Regions Hospital, Saint Paul

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55435

RECRUITING

Fairview Southdale Hospital, Edina

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

RECRUITING

Essentia Health Saint Mary's Medical Center, Duluth

RECRUITING

Miller-Dwan Hospital, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56401

RECRUITING

Essentia Health Saint Joseph's Medical Center, Brainerd

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

61114

RECRUITING

UW Health Carbone Cancer Center Rockford, Rockford

61801

RECRUITING

Carle Cancer Center, Urbana

RECRUITING

The Carle Foundation Hospital, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

RECRUITING

Alton Memorial Hospital, Alton

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

RECRUITING

Memorial Hospital East, Shiloh

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63110

RECRUITING

Washington University School of Medicine, St Louis

63128

RECRUITING

Mercy Hospital South, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

RECRUITING

Mercy Hospital Saint Louis, St Louis

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

65212

RECRUITING

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia

65804

RECRUITING

Mercy Hospital Springfield, Springfield

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70002

RECRUITING

Mary Bird Perkins Cancer Center - Metairie, Metairie

70006

ACTIVE_NOT_RECRUITING

East Jefferson General Hospital, Metairie

ACTIVE_NOT_RECRUITING

LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie

70112

ACTIVE_NOT_RECRUITING

Louisiana State University Health Science Center, New Orleans

ACTIVE_NOT_RECRUITING

University Medical Center New Orleans, New Orleans

70115

ACTIVE_NOT_RECRUITING

Touro Infirmary, New Orleans

70809

RECRUITING

Louisiana Hematology Oncology Associates LLC, Baton Rouge

RECRUITING

Mary Bird Perkins Cancer Center, Baton Rouge

72205

RECRUITING

University of Arkansas for Medical Sciences, Little Rock

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

74146

RECRUITING

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75080

RECRUITING

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75235

RECRUITING

Parkland Memorial Hospital, Dallas

75237

RECRUITING

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80124

RECRUITING

UCHealth Lone Tree Health Center, Lone Tree

80129

RECRUITING

UCHealth Highlands Ranch Hospital, Highlands Ranch

80206

RECRUITING

UCHealth - Cherry Creek, Denver

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80631

RECRUITING

UCHealth Greeley Hospital, Greeley

87102

RECRUITING

Lovelace Medical Center-Saint Joseph Square, Albuquerque

87109

RECRUITING

Lovelace Radiation Oncology, Albuquerque

91010

ACTIVE_NOT_RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92024

RECRUITING

UC San Diego Health System - Encinitas, Encinitas

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93105

RECRUITING

Ridley-Tree Cancer Center, Santa Barbara

93401

ACTIVE_NOT_RECRUITING

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

RECRUITING

PCR Oncology, Arroyo Grande

94010

RECRUITING

Mills-Peninsula Medical Center, Burlingame

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94401

RECRUITING

Mills Health Center, San Mateo

95355

RECRUITING

Memorial Medical Center, Modesto

95403

RECRUITING

Sutter Pacific Medical Foundation, Santa Rosa

95661

RECRUITING

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

RECRUITING

Sutter Roseville Medical Center, Roseville

95816

RECRUITING

Sutter Medical Center Sacramento, Sacramento

98101

RECRUITING

Virginia Mason Medical Center, Seattle

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

04530

ACTIVE_NOT_RECRUITING

MaineHealth Coastal Cancer Treatment Center, Bath

04005

ACTIVE_NOT_RECRUITING

MaineHealth Maine Medical Center - Biddeford, Biddeford

04102

ACTIVE_NOT_RECRUITING

MaineHealth Maine Medical Center - Portland, Portland

04073

ACTIVE_NOT_RECRUITING

MaineHealth Cancer Care and IV Therapy - Sanford, Sanford

ACTIVE_NOT_RECRUITING

MaineHealth Cancer Care Center of York County, Sanford

04074

ACTIVE_NOT_RECRUITING

MaineHealth Maine Medical Center- Scarborough, Scarborough

04106

ACTIVE_NOT_RECRUITING

MaineHealth Cancer Care and IV Therapy - South Portland, South Portland

01915

RECRUITING

Beverly Hospital, Beverly

02114

RECRUITING

Massachusetts General Hospital Cancer Center, Boston

02115

RECRUITING

Brigham and Women's Hospital, Boston

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

01805

RECRUITING

Lahey Hospital and Medical Center, Burlington

01930

RECRUITING

Addison Gilbert Hospital, Gloucester

01960

RECRUITING

Lahey Medical Center-Peabody, Peabody

01890

ACTIVE_NOT_RECRUITING

Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08103

RECRUITING

Cooper Hospital University Medical Center, Camden

08701

RECRUITING

Monmouth Medical Center Southern Campus, Lakewood

07740

RECRUITING

Monmouth Medical Center, Long Branch

07748

RECRUITING

Memorial Sloan Kettering Monmouth, Middletown

07645

RECRUITING

Memorial Sloan Kettering Bergen, Montvale

08054

RECRUITING

Cooper CyberKnife Center, Mount Laurel

08903

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

07101

RECRUITING

Rutgers New Jersey Medical School, Newark

08755

RECRUITING

Community Medical Center, Toms River

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

05602

RECRUITING

Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners

05401

RECRUITING

University of Vermont Medical Center, Burlington

05405

RECRUITING

University of Vermont and State Agricultural College, Burlington

M5G 2M9

SUSPENDED

University Health Network-Princess Margaret Hospital, Toronto

G1R 2J6

SUSPENDED

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER

NCT05327686 - Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial | Biotech Hunter | Biotech Hunter