240
Participants
Start Date
February 1, 2023
Primary Completion Date
June 15, 2028
Study Completion Date
June 15, 2028
Avelumab
Given IV
Axitinib
Given PO
Biospecimen Collection
Undergo collection of blood
Bone Scan
Undergo bone scan
Cabozantinib
Given PO
Computed Tomography
Undergo CT
Ipilimumab
Given IV
Lenvatinib
Given PO
Magnetic Resonance Imaging
Undergo MRI
Nivolumab
Given IV
Pembrolizumab
Given IV
Stereotactic Ablative Radiotherapy
42 Gy in 3 fractions
RECRUITING
Saint Lukes Hospital, Dublin
RECRUITING
Beacon Hospital, Dublin
RECRUITING
Peter MacCallum Cancer Centre, Melbourne
RECRUITING
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
RECRUITING
Memorial Sloan Kettering Cancer Center, New York
RECRUITING
Memorial Sloan Kettering Westchester, Harrison
RECRUITING
Memorial Sloan Kettering Nassau, Uniondale
RECRUITING
Memorial Sloan Kettering Commack, Commack
ACTIVE_NOT_RECRUITING
Stony Brook University Medical Center, Stony Brook
RECRUITING
Glens Falls Hospital, Glens Falls
RECRUITING
UPMC-Heritage Valley Health System Beaver, Beaver
RECRUITING
UPMC-Magee Womens Hospital, Pittsburgh
RECRUITING
UPMC-Saint Margaret, Pittsburgh
RECRUITING
University of Pittsburgh Cancer Institute (UPCI), Pittsburgh
RECRUITING
UPMC-Shadyside Hospital, Pittsburgh
RECRUITING
UPMC-Passavant Hospital, Pittsburgh
RECRUITING
UPMC-Saint Clair Hospital Cancer Center, Pittsburgh
RECRUITING
UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg
RECRUITING
UPMC Hillman Cancer Center - New Castle, New Castle
RECRUITING
UPMC Hillman Cancer Center Erie, Erie
RECRUITING
Carlisle Regional Cancer Center, Carlisle
RECRUITING
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion, Mechanicsburg
RECRUITING
UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Harrisburg
RECRUITING
UPMC Memorial, York
RECRUITING
Divine Providence Hospital, Williamsport
RECRUITING
Lehigh Valley Hospital - Muhlenberg, Bethlehem
RECRUITING
Lehigh Valley Hospital-Cedar Crest, Allentown
RECRUITING
Reading Hospital, West Reading
ACTIVE_NOT_RECRUITING
Central Maryland Radiation Oncology in Howard County, Columbia
ACTIVE_NOT_RECRUITING
UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie
ACTIVE_NOT_RECRUITING
University of Maryland/Greenebaum Cancer Center, Baltimore
RECRUITING
Bon Secours Saint Francis Medical Center, Midlothian
RECRUITING
Bon Secours Cancer Institute at Reynolds Crossing, Richmond
RECRUITING
West Virginia University Charleston Division, Charleston
RECRUITING
Edwards Comprehensive Cancer Center, Huntington
RECRUITING
Wake Forest University at Clemmons, Clemmons
RECRUITING
Wake Forest University Health Sciences, Winston-Salem
RECRUITING
Hayworth Cancer Center, High Point
RECRUITING
UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RECRUITING
Duke University Medical Center, Durham
RECRUITING
Atrium Health Cabarrus/LCI-Concord, Concord
RECRUITING
Levine Cancer Institute-Gaston, Gastonia
RECRUITING
Atrium Health Union/LCI-Union, Monroe
RECRUITING
Carolinas Medical Center/Levine Cancer Institute, Charlotte
RECRUITING
Atrium Health Pineville/LCI-Pineville, Charlotte
RECRUITING
Atrium Health University City/LCI-University, Charlotte
RECRUITING
Levine Cancer Institute-Ballantyne, Charlotte
RECRUITING
Wake Forest Baptist Health - Wilkes Medical Center, Wilkesboro
RECRUITING
Medical University of South Carolina, Charleston
RECRUITING
Self Regional Healthcare, Greenwood
RECRUITING
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood
RECRUITING
Memorial Hospital West, Pembroke Pines
RECRUITING
Mount Sinai Medical Center, Miami Beach
RECRUITING
Miami Cancer Institute, Miami
RECRUITING
Mount Sinai Comprehensive Cancer Center at Aventura, Aventura
ACTIVE_NOT_RECRUITING
University of Alabama at Birmingham Cancer Center, Birmingham
RECRUITING
Ohio State University Comprehensive Cancer Center, Columbus
RECRUITING
UH Seidman Cancer Center at UH Avon Health Center, Avon
RECRUITING
UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor
RECRUITING
Case Western Reserve University, Cleveland
RECRUITING
UHHS-Chagrin Highlands Medical Center, Beachwood
RECRUITING
University Hospitals Parma Medical Center, Parma
RECRUITING
University Hospitals Portage Medical Center, Ravenna
RECRUITING
Dayton Physicians LLC-Atrium, Franklin
RECRUITING
University of Cincinnati Cancer Center-West Chester, West Chester
RECRUITING
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
RECRUITING
Miami Valley Cancer Care and Infusion, Greenville
RECRUITING
Upper Valley Medical Center, Troy
RECRUITING
Miami Valley Hospital, Dayton
RECRUITING
Premier Blood and Cancer Center, Dayton
RECRUITING
Dayton Physician LLC - Englewood, Dayton
RECRUITING
Miami Valley Hospital North, Dayton
RECRUITING
Dayton Physicians LLC-Miami Valley South, Centerville
RECRUITING
Miami Valley Hospital South, Centerville
RECRUITING
Corewell Health William Beaumont University Hospital, Royal Oak
RECRUITING
Corewell Health Beaumont Troy Hospital, Troy
RECRUITING
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
RECRUITING
University of Michigan Comprehensive Cancer Center, Ann Arbor
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
RECRUITING
Trinity Health Medical Center - Brighton, Brighton
RECRUITING
Chelsea Hospital, Chelsea
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
RECRUITING
Corewell Health Dearborn Hospital, Dearborn
RECRUITING
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
RECRUITING
Trinity Health Medical Center - Canton, Canton
RECRUITING
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
RECRUITING
Corewell Health Farmington Hills Hospital, Farmington Hills
RECRUITING
University of Michigan Health - Sparrow Lansing, Lansing
RECRUITING
Mary Greeley Medical Center, Ames
RECRUITING
McFarland Clinic - Ames, Ames
RECRUITING
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny
RECRUITING
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee
RECRUITING
Iowa Methodist Medical Center, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines
RECRUITING
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive
RECRUITING
Froedtert Menomonee Falls Hospital, Menomonee Falls
RECRUITING
ProHealth Oconomowoc Memorial Hospital, Oconomowoc
RECRUITING
Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend
RECRUITING
ProHealth D N Greenwald Center, Mukwonago
RECRUITING
Drexel Town Square Health Center, Oak Creek
RECRUITING
UW Cancer Center at ProHealth Care, Waukesha
RECRUITING
Medical College of Wisconsin, Milwaukee
RECRUITING
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
RECRUITING
University of Wisconsin Carbone Cancer Center - University Hospital, Madison
RECRUITING
Cancer Center of Western Wisconsin, New Richmond
RECRUITING
Aspirus Regional Cancer Center, Wausau
RECRUITING
Langlade Hospital and Cancer Center, Antigo
RECRUITING
Marshfield Medical Center-Marshfield, Marshfield
ACTIVE_NOT_RECRUITING
Marshfield Medical Center - Neillsville, Neillsville
RECRUITING
Marshfield Medical Center - Weston, Weston
RECRUITING
Aspirus Cancer Care - Stevens Point, Stevens Point
RECRUITING
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
RECRUITING
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
ACTIVE_NOT_RECRUITING
Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids
RECRUITING
Aspirus Cancer Care - James Beck Cancer Center, Rhinelander
RECRUITING
Marshfield Medical Center - Minocqua, Minocqua
RECRUITING
Marshfield Medical Center-EC Cancer Center, Eau Claire
RECRUITING
Essentia Health-Spooner Clinic, Spooner
RECRUITING
Duluth Clinic Ashland, Ashland
RECRUITING
Northwest Wisconsin Cancer Center, Ashland
RECRUITING
Essentia Health-Hayward Clinic, Hayward
ACTIVE_NOT_RECRUITING
Marshfield Medical Center - Ladysmith, Ladysmith
RECRUITING
Marshfield Medical Center-Rice Lake, Rice Lake
RECRUITING
Essentia Health Saint Mary's Hospital - Superior, Superior
RECRUITING
Essentia Health Sandstone, Sandstone
RECRUITING
Lakeview Hospital, Stillwater
RECRUITING
Regions Hospital, Saint Paul
RECRUITING
Hennepin County Medical Center, Minneapolis
RECRUITING
Fairview Southdale Hospital, Edina
RECRUITING
Essentia Health Hibbing Clinic, Hibbing
RECRUITING
Essentia Health Virginia Clinic, Virginia
RECRUITING
Essentia Health Cancer Center, Duluth
RECRUITING
Essentia Health Saint Mary's Medical Center, Duluth
RECRUITING
Miller-Dwan Hospital, Duluth
RECRUITING
Mayo Clinic in Rochester, Rochester
RECRUITING
Essentia Health Saint Joseph's Medical Center, Brainerd
RECRUITING
Sanford Joe Lueken Cancer Center, Bemidji
RECRUITING
Essentia Health - Deer River Clinic, Deer River
RECRUITING
Sanford Cancer Center Oncology Clinic, Sioux Falls
RECRUITING
Sanford Broadway Medical Center, Fargo
RECRUITING
Sanford Roger Maris Cancer Center, Fargo
RECRUITING
Sanford Bismarck Medical Center, Bismarck
RECRUITING
Northwestern Medicine Glenview Outpatient Center, Glenview
RECRUITING
Northwestern Medicine Grayslake Outpatient Center, Grayslake
RECRUITING
Northwestern Medicine Lake Forest Hospital, Lake Forest
RECRUITING
Northwestern Medicine Cancer Center Kishwaukee, DeKalb
RECRUITING
Northwestern Medicine Cancer Center Delnor, Geneva
RECRUITING
Northwestern Medicine Cancer Center Warrenville, Warrenville
RECRUITING
Northwestern University, Chicago
RECRUITING
UW Health Carbone Cancer Center Rockford, Rockford
RECRUITING
Carle Cancer Center, Urbana
RECRUITING
The Carle Foundation Hospital, Urbana
RECRUITING
Carle at The Riverfront, Danville
RECRUITING
Carle Physician Group-Mattoon/Charleston, Mattoon
RECRUITING
Alton Memorial Hospital, Alton
RECRUITING
Cancer Care Center of O'Fallon, O'Fallon
RECRUITING
HSHS Saint Elizabeth's Hospital, O'Fallon
RECRUITING
Memorial Hospital East, Shiloh
RECRUITING
Carle Physician Group-Effingham, Effingham
RECRUITING
Crossroads Cancer Center, Effingham
RECRUITING
Cancer Care Specialists of Illinois - Decatur, Decatur
RECRUITING
Decatur Memorial Hospital, Decatur
RECRUITING
Southern Illinois University School of Medicine, Springfield
RECRUITING
Springfield Clinic, Springfield
RECRUITING
Springfield Memorial Hospital, Springfield
RECRUITING
Centralia Oncology Clinic, Centralia
RECRUITING
Washington University School of Medicine, St Louis
RECRUITING
Mercy Hospital South, St Louis
RECRUITING
Siteman Cancer Center-South County, St Louis
RECRUITING
Siteman Cancer Center at Christian Hospital, St Louis
RECRUITING
Siteman Cancer Center at West County Hospital, Creve Coeur
RECRUITING
Mercy Hospital Saint Louis, St Louis
RECRUITING
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
RECRUITING
Saint Francis Medical Center, Cape Girardeau
RECRUITING
MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia
RECRUITING
Mercy Hospital Springfield, Springfield
RECRUITING
Nebraska Medicine-Village Pointe, Omaha
RECRUITING
Nebraska Medicine-Bellevue, Bellevue
RECRUITING
University of Nebraska Medical Center, Omaha
RECRUITING
Mary Bird Perkins Cancer Center - Metairie, Metairie
ACTIVE_NOT_RECRUITING
East Jefferson General Hospital, Metairie
ACTIVE_NOT_RECRUITING
LSU Healthcare Network / Metairie Multi-Specialty Clinic, Metairie
ACTIVE_NOT_RECRUITING
Louisiana State University Health Science Center, New Orleans
ACTIVE_NOT_RECRUITING
University Medical Center New Orleans, New Orleans
ACTIVE_NOT_RECRUITING
Touro Infirmary, New Orleans
RECRUITING
Louisiana Hematology Oncology Associates LLC, Baton Rouge
RECRUITING
Mary Bird Perkins Cancer Center, Baton Rouge
RECRUITING
University of Arkansas for Medical Sciences, Little Rock
RECRUITING
University of Oklahoma Health Sciences Center, Oklahoma City
RECRUITING
Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa
RECRUITING
UT Southwestern Clinical Center at Richardson/Plano, Richardson
RECRUITING
Parkland Memorial Hospital, Dallas
RECRUITING
UT Southwestern Simmons Cancer Center - RedBird, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
RECRUITING
UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth
RECRUITING
UCHealth University of Colorado Hospital, Aurora
RECRUITING
UCHealth Lone Tree Health Center, Lone Tree
RECRUITING
UCHealth Highlands Ranch Hospital, Highlands Ranch
RECRUITING
UCHealth - Cherry Creek, Denver
RECRUITING
Poudre Valley Hospital, Fort Collins
RECRUITING
Cancer Care and Hematology-Fort Collins, Fort Collins
RECRUITING
Medical Center of the Rockies, Loveland
RECRUITING
UCHealth Greeley Hospital, Greeley
RECRUITING
Lovelace Medical Center-Saint Joseph Square, Albuquerque
RECRUITING
Lovelace Radiation Oncology, Albuquerque
ACTIVE_NOT_RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
UC San Diego Health System - Encinitas, Encinitas
RECRUITING
UC San Diego Moores Cancer Center, La Jolla
RECRUITING
UC San Diego Medical Center - Hillcrest, San Diego
RECRUITING
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
RECRUITING
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
RECRUITING
Ridley-Tree Cancer Center, Santa Barbara
ACTIVE_NOT_RECRUITING
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
RECRUITING
PCR Oncology, Arroyo Grande
RECRUITING
Mills-Peninsula Medical Center, Burlingame
RECRUITING
UCSF Medical Center-Mission Bay, San Francisco
RECRUITING
Mills Health Center, San Mateo
RECRUITING
Memorial Medical Center, Modesto
RECRUITING
Sutter Pacific Medical Foundation, Santa Rosa
RECRUITING
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
RECRUITING
Sutter Roseville Medical Center, Roseville
RECRUITING
Sutter Medical Center Sacramento, Sacramento
RECRUITING
Virginia Mason Medical Center, Seattle
RECRUITING
Mayo Clinic in Florida, Jacksonville
ACTIVE_NOT_RECRUITING
MaineHealth Coastal Cancer Treatment Center, Bath
ACTIVE_NOT_RECRUITING
MaineHealth Maine Medical Center - Biddeford, Biddeford
ACTIVE_NOT_RECRUITING
MaineHealth Maine Medical Center - Portland, Portland
ACTIVE_NOT_RECRUITING
MaineHealth Cancer Care and IV Therapy - Sanford, Sanford
ACTIVE_NOT_RECRUITING
MaineHealth Cancer Care Center of York County, Sanford
ACTIVE_NOT_RECRUITING
MaineHealth Maine Medical Center- Scarborough, Scarborough
ACTIVE_NOT_RECRUITING
MaineHealth Cancer Care and IV Therapy - South Portland, South Portland
RECRUITING
Beverly Hospital, Beverly
RECRUITING
Massachusetts General Hospital Cancer Center, Boston
RECRUITING
Brigham and Women's Hospital, Boston
RECRUITING
Dana-Farber Cancer Institute, Boston
RECRUITING
Lahey Hospital and Medical Center, Burlington
RECRUITING
Addison Gilbert Hospital, Gloucester
RECRUITING
Lahey Medical Center-Peabody, Peabody
ACTIVE_NOT_RECRUITING
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care, Winchester
RECRUITING
Memorial Sloan Kettering Basking Ridge, Basking Ridge
RECRUITING
Cooper Hospital University Medical Center, Camden
RECRUITING
Monmouth Medical Center Southern Campus, Lakewood
RECRUITING
Monmouth Medical Center, Long Branch
RECRUITING
Memorial Sloan Kettering Monmouth, Middletown
RECRUITING
Memorial Sloan Kettering Bergen, Montvale
RECRUITING
Cooper CyberKnife Center, Mount Laurel
RECRUITING
Rutgers Cancer Institute of New Jersey, New Brunswick
RECRUITING
Rutgers New Jersey Medical School, Newark
RECRUITING
Community Medical Center, Toms River
RECRUITING
Atrium Medical Center-Middletown Regional Hospital, Franklin
RECRUITING
Sanford USD Medical Center - Sioux Falls, Sioux Falls
RECRUITING
Central Vermont Medical Center/National Life Cancer Treatment, Berlin Corners
RECRUITING
University of Vermont Medical Center, Burlington
RECRUITING
University of Vermont and State Agricultural College, Burlington
SUSPENDED
University Health Network-Princess Margaret Hospital, Toronto
SUSPENDED
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER