256
Participants
Start Date
August 17, 2022
Primary Completion Date
June 20, 2025
Study Completion Date
June 25, 2026
Avelumab
Participants will receive avelumab intravenous infusion at a dose of 800 milligrams (mg) once every 2 weeks (Q2W) until unacceptable toxicity, withdraw consent or initiation of a new treatment.
Sacituzumab Govitecan
Participants will receive sacituzumab govitecan intravenous infusion at dose of 10 milligrams per kilogram (mg/kg) of body weight once a week (Q1W) on Day 1 and 8 of 21-day treatment cycles, in combination with avelumab 800 mg Q2W, until unacceptable toxicity, withdraw consent or initiation of a new treatment.
M6223
Participants will receive M6223 (anti-T cell-immuno-receptor with Ig and ITM domains \[anti-TIGIT\]) intravenous infusion at dose of 1600 mg Q2W in combination with avelumab 800 mg Q2W, until unacceptable toxicity, withdraw consent or initiation of a new treatment.
NKTR-255
Participants will receive NKTR-255 intravenous infusion at a dose of 3 micrograms per kilogram body weight (mcg/kg) once every 4 weeks (Q4W) in combination with avelumab 800 mg Q2W, until unacceptable toxicity, withdraw consent or initiation of a new treatment.
The Johns Hopkins Hospital, Baltimore
Kliniken Maria Hilf GmbH - Klinik fuer Urologie, Muenchen
University of Wisconsin Cancer Center, Madison
AMR Kansas City, Formerly Center for Pharmaceutical Research, an AMR company - Kansas City, MO at St. Joseph Medical Center, Kansas City
University of Kansas Medical Center Research Institute, Inc. - 3901 Rainbow (MAIN), Kansas City
Beacon Cancer Care, Coeur d'Alene
Hôpital Foch - Service d'Oncologie Médicale, Suresnes
Seattle Cancer Care Alliance, Seattle
Multicare Health System Tacoma General Hospital, Tacoma
Johns Hopkins University, Baltimore
Flinders Medical Centre, Bedford Park
Sunshine Hospital - PARENT, Footscray
Ashford Cancer Centre Research, Kurralta Park
Liverpool Hospital - PARENT, Liverpool
Calvary Mater Newcastle - PARENT, Newcastle
Tasman Oncology Research Ltd - Oncology, Southport
Macquarie University Hospital - PARENT, Sydney
The Kinghorn Can Cen, Westmead
ZNA Middelheim - Middelheim - account 2, Antwerp
AZ Klina - PARENT, Brasschaat
Institut Jules Bordet - Medical Oncology, Brussels
Universitair Ziekenhuis Gent - Medical Oncology, Ghent
AZ Groeninge - Campus Kennedylaan - account 2, Kortrijk
Centre Hospitalier de l'Ardenne - PARENT, Libramont
CHU de Liège - PARENT, Liège
Universitaetsklinikum Wuerzburg - Klinik u. Poliklinik f. Urologie u. Kinderurologie, Wuerzburg
William Osler Health System - Brampton Civic Hospital, Brampton
CISSS de la Monteregie-Centre - Hospital Charles Le Moyne, Greenfield Park
CHUM Centre de Recherche, Montreal
The Ottawa Hospital Cancer Centre, Ottawa
ICO - Site Paul Papin - service d'oncologie medicale, Angers
Institut Bergonié - Service d'Oncologie Médicale, Bordeaux
Centre François Baclesse - Pathologies Gynecologiques, Caen
Hôpital Henri Mondor - Service d'Oncologie Médicale, Créteil
Clinique Victor Hugo - Centre Jean Bernard - Service d'Oncologie Médical, Le Mans
Centre Leon Berard - Service d'Oncologie Medicale, Lyon
Hôpital de la Timone - service d'urologie, Marseille
Hopital Caremeau - Service Hématologie Clinique/Oncologie Médicale, Nîmes
Hôpital Cochin - Hematologie et Oncologie Médicale, Paris
CHU Poitiers - Hôpital la Milétrie - service d'oncologie médicale, Poitiers
CRLCC Eugene Marquis - Service d'Oncologie médicale, Rennes
ICO - Site René Gauducheau - Service d'Oncologie medicale, Saint-Herblain
Clinique Sainte-Anne - Service d'Oncologie Médicale, Strasbourg
Institut de Cancérologie de Strasbourg Europe - ICANS - Service d'oncologie médicale, Strasbourg
Universitaetsklinikum Essen - Westdeutsches Tumorzentrum, Essen
Universitaetsklinikum Frankfurt Goethe-Universitaet - Urologie und Kinderurologie2, Frankfurt
Universitaetsklinikum Wuerzburg - Klinik u. Poliklinik f. Urologie u. Kinderurologie, Halle
Kliniken Maria Hilf GmbH - Klinik fuer Urologie, Mönchengladbach
Universitaetsklinikum Muenster - Klinik und Poliklinik fuer Urologie, Münster
Universitaetsklinikum Tuebingen - Klinik fuer Urologie, Tübingen
Athens Medical Center, Athens
"General Hospital of Athens Alexandra", Athens
"University General Hospital Attikon", Athens
Euromedica General Clinic of Thessaloniki, Thessaloniki
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS - Oncologia Medica, Bologna
Azienda Ospedaliera Universitaria Careggi - S.O.D. di Oncologia Medica, Florence
"IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori Dino Amadori - IRST - Oncologia", Forlì
Fondazione IRCCS Istituto Nazionale dei Tumori - S.S. Oncologia Medica Genitourinaria, Milan
Ospedale San Raffaele - U.O. di Oncologia Medica, Milan
Humanitas Istituto Clinico Catanese - Oncologia Medica, Misterbianco
Istituto Nazionale Tumori Fondazione G. Pascale - Oncologia Medica A, Napoli
Istituto Nazionale Tumori Regina Elena IRCCS - Urologia, Napoli
IOV - Istituto Oncologico Veneto IRCCS - U.O. Oncologia Medica 1, Padua
Azienda Ospedaliero Universitaria Pisana - U.O. Oncologia, Pisa
Ospedale Santa Maria delle Croci, Ravenna
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Oncologia Medica, Rome
IRCCS Ospedale Casa Sollievo della Sofferenza - Dipartimento di Oncologia Medica, San Giovanni Rotondo
Azienda Ospedaliera S. Maria Di Terni - S.C. Oncologia Medica, Terni
Chungnam National University Hospital - Department of Internal Medicine (Rheumatology), Daejeon
National Cancer Center, Gyeonggi-do
Seoul National University Bundang Hospital, Seongnam-si
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University Health System, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
Hospital Infanta Cristina - Unidad de Fase I, Badajoz
Hospital Clinic de Barcelona - Servicio de Oncologia, Barcelona
Hospital de la Santa Creu i Sant Pau - Dept of Oncology, Barcelona
Hospital del Mar - Servicio de Oncologia, Barcelona
Hospital Universitario Virgen del Rocio - Oncology Service, Barcelona
Hospital Universitario Reina Sofia - Dept of Oncology, Córdoba
Hospital General Universitario de Elche - Servicio de Oncologia, Elche
Hospital Universitario Lucus Augusti - Oncology, Lugo
Hospital General Universitario Gregorio Marañon - Servicio de Oncologia Medica, Madrid
ALTHAIA, Xarxa assistencial Universitaria de Manresa - Oncology Dept, Manresa
Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City
China Medical University Hospital, Taichung
Chi Mei Hospital, Liouying, Tainan City
National Taiwan University Hospital, Taipei
Taipei Veterans General Hospital, Taipei
Chang Gung Memorial Hospital,Linkou, Taoyuan District
The Christie Hospital - Dept of Oncology, Manchester
Royal Preston Hospital - Rosemere Cancer Centre, Preston
Universitaetsklinikum Halle (Saale) - Universitaetsklinik und Poliklinik fuer Urologie, Halle
Barts Hospital - Dept of Medical Oncology, London
Merck KGaA, Darmstadt, Germany; Gilead Sciences; Nektar Therapeutics
UNKNOWN
EMD Serono Research & Development Institute, Inc.
INDUSTRY