Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

PHASE2RecruitingINTERVENTIONAL
Enrollment

88

Participants

Timeline

Start Date

November 14, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
Interventions
DRUG

BET Bromodomain Inhibitor ZEN-3694

Given PO

PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Diagnostic Imaging Testing

Undergo diagnostic imaging

DRUG

Talazoparib

Given PO

Trial Locations (36)

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20892

RECRUITING

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

ACTIVE_NOT_RECRUITING

National Institutes of Health Clinical Center, Bethesda

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

32610

ACTIVE_NOT_RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

60611

RECRUITING

Northwestern University, Chicago

64064

RECRUITING

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

SUSPENDED

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

RECRUITING

University of Kansas Cancer Center - North, Kansas City

66160

RECRUITING

University of Kansas Cancer Center, Kansas City

66205

RECRUITING

University of Kansas Clinical Research Center, Fairway

RECRUITING

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

RECRUITING

University of Kansas Cancer Center-Overland Park, Overland Park

66211

RECRUITING

University of Kansas Hospital-Indian Creek Campus, Overland Park

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

77030

RECRUITING

M D Anderson Cancer Center, Houston

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78712

ACTIVE_NOT_RECRUITING

University of Texas at Austin, Austin

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90020

RECRUITING

Keck Medicine of USC Koreatown, Los Angeles

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92103

RECRUITING

UC San Diego Medical Center - Hillcrest, San Diego

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

92663

RECRUITING

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

06520

RECRUITING

Yale University, New Haven

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

77555-0565

RECRUITING

University of Texas Medical Branch, Galveston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH