Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition.

NARecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

December 30, 2027

Study Completion Date

March 30, 2028

Conditions
MalnutritionSarcopenia
Interventions
DIETARY_SUPPLEMENT

BCAA

daily administration of oral nutritional supplements (ONS) 1) providing whole proteins together with dietary advice according with the ESPEN nutrition guidelines. All the patients will receive the standard commercially available product used at CHUV (Resource protein ®, nestle) and nutritional counselling (SC) and 4 gram per day of BCAAs mixture. Ratio between the BCAAs will be Leucine/Isoleucine/Valine=2:1:1

DIETARY_SUPPLEMENT

Micronutriments

daily administration of oral nutritional supplements (ONS) 1) providing whole proteins together with dietary advice according with the ESPEN nutrition guidelines. All the patients will receive the standard commercially available product used at CHUV (Resource protein ®, nestle ) and nutritional counselling (SC) and Vitamin A 1200 mg RE, Vitamin D3 2000 IU, Thiamine B1 100 mg, Cobalamin B12 10 mcg, Ascorbic acid C 200 mg, Iron 30 mg, Selenium 100 mcg, Zinc 20 mg, Omega-3 PUFA 1 g

DIETARY_SUPPLEMENT

standard treatment + placebo

daily administration of oral nutritional supplements (ONS) 1) providing whole proteins together with dietary advice according with the ESPEN nutrition guidelines. All the patients will receive the standard commercially available product used at CHUV (Resource protein ®, nestle ) and nutritional counselling (SC) and maltodextrin 4 g as placebo

Trial Locations (1)

1012

RECRUITING

CHUV, Lausanne

All Listed Sponsors
lead

Patrizia D'Amelio

OTHER