96
Participants
Start Date
April 12, 2022
Primary Completion Date
August 24, 2023
Study Completion Date
August 24, 2023
10% lidocaine spray
10% lidocaine spray 3 puff for the throat before induction
Placebo of lidocaine spray
Normal saline spray 3 puff for the throat before induction
Cisatracurium
Intravenous cisatracurium 0.12 mg/kg during induction
Placebo of cisatracurium
Intravenous normal saline during induction
Propofol
The dosage of intravenous propofol for the first subjects was predetermined for each arm, and the dosage for the subsequent subjects would be determined according to the response of the previous subjects using the Dixon's up-and-down method with a step size of 0.25 mg/kg. If the subjects had no movement and stable hemodynamic status during and after the laryngeal mask airway (LMA) placement, the predetermined dosage of propofol for the subsequent subject would be decreased by 0.25 mg/kg. On the other hand, if the subjects had obvious movement, failure to LMA placement, and significant hemodynamic changes, the predetermined dosage of propofol for the subsequent subject would be increased by 0.25 mg/kg.
Linkup Chang Gung Memorial Hospital, Taoyuan
Chang Gung Memorial Hospital
OTHER