Muscle Relaxants and Laryngeal Local Anesthetics for Laryngeal Mask Airway Insertion Decreasing Propofol in Elderly

NACompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

April 12, 2022

Primary Completion Date

August 24, 2023

Study Completion Date

August 24, 2023

Conditions
Anesthesia, General
Interventions
DRUG

10% lidocaine spray

10% lidocaine spray 3 puff for the throat before induction

DRUG

Placebo of lidocaine spray

Normal saline spray 3 puff for the throat before induction

DRUG

Cisatracurium

Intravenous cisatracurium 0.12 mg/kg during induction

DRUG

Placebo of cisatracurium

Intravenous normal saline during induction

DRUG

Propofol

The dosage of intravenous propofol for the first subjects was predetermined for each arm, and the dosage for the subsequent subjects would be determined according to the response of the previous subjects using the Dixon's up-and-down method with a step size of 0.25 mg/kg. If the subjects had no movement and stable hemodynamic status during and after the laryngeal mask airway (LMA) placement, the predetermined dosage of propofol for the subsequent subject would be decreased by 0.25 mg/kg. On the other hand, if the subjects had obvious movement, failure to LMA placement, and significant hemodynamic changes, the predetermined dosage of propofol for the subsequent subject would be increased by 0.25 mg/kg.

Trial Locations (1)

33305

Linkup Chang Gung Memorial Hospital, Taoyuan

All Listed Sponsors
lead

Chang Gung Memorial Hospital

OTHER