Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

July 19, 2022

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
Metastatic Colon AdenocarcinomaMetastatic Rectal AdenocarcinomaStage III Colon Cancer AJCC v8Stage III Rectal Cancer AJCC v8Stage IV Colon Cancer AJCC v8Stage IV Rectal Cancer AJCC v8Unresectable Colon AdenocarcinomaUnresectable Rectal Adenocarcinoma
Interventions
BIOLOGICAL

Cetuximab

Given IV

DRUG

Encorafenib

Given PO

BIOLOGICAL

Nivolumab

Given IV

Trial Locations (286)

14263

Roswell Park Cancer Institute, Buffalo

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19611

Reading Hospital, West Reading

26330

United Hospital Center, Bridgeport

26506

West Virginia University Healthcare, Morgantown

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28374

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst

28546

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29425

Medical University of South Carolina, Charleston

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30265

CTCA at Southeastern Regional Medical Center, Newnan

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43015

Delaware Health Center-Grady Cancer Center, Delaware

Grady Memorial Hospital, Delaware

43016

Columbus Oncology and Hematology Associates, Dublin

43040

Memorial Hospital, Marysville

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

43081

Saint Ann's Hospital, Westerville

43123

Mount Carmel Grove City Hospital, Grove City

43130

Fairfield Medical Center, Lancaster

43213

Mount Carmel East Hospital, Columbus

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43228

Doctors Hospital, Columbus

43302

OhioHealth Marion General Hospital, Marion

43623

Toledo Clinic Cancer Centers-Toledo, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44903

OhioHealth Mansfield Hospital, Mansfield

45005

Dayton Physicians LLC-Atrium, Franklin

45331

Miami Valley Cancer Care and Infusion, Greenville

45373

Upper Valley Medical Center, Troy

45409

Miami Valley Hospital, Dayton

Premier Blood and Cancer Center, Dayton

45415

Dayton Physician LLC - Englewood, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45459

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

46158

Franciscan Health Mooresville, Mooresville

46237

Franciscan Health Indianapolis, Indianapolis

46307

Northwest Cancer Center - Main Campus, Crown Point

46311

Northwest Oncology LLC, Dyer

46312

Saint Catherine Hospital, Indianapolis

46321

The Community Hospital, Munster

Women's Diagnostic Center - Munster, Munster

46342

Northwest Cancer Center - Hobart, Hobart

Saint Mary Medical Center, Hobart

46360

Woodland Cancer Care Center, Michigan City

46383

Northwest Cancer Center - Valparaiso, Valparaiso

47905

Franciscan Saint Elizabeth Health - Lafayette East, Lafayette

48044

Henry Ford Saint John Hospital - Macomb Medical, Macomb

48054

Henry Ford River District Hospital, East China Township

48075

Henry Ford Health Providence Southfield Hospital, Southfield

48093

Henry Ford Health Warren Hospital, Warren

Henry Ford Warren Hospital - GLCMS, Warren

Macomb Hematology Oncology PC, Warren

48106

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48114

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

Trinity Health Medical Center - Brighton, Brighton

48118

Chelsea Hospital, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

Trinity Health Medical Center - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48202

Henry Ford Hospital, Detroit

48236

Henry Ford Health Saint John Hospital, Detroit

Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods

Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48374

Henry Ford Health Providence Novi Hospital, Novi

48377

Henry Ford Medical Center-Columbus, Novi

48503

Cancer Hematology Centers - Flint, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

MyMichigan Medical Center Saginaw, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48764

MyMichigan Medical Center Tawas, Tawas City

48912

University of Michigan Health - Sparrow Lansing, Lansing

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49009

Beacon Kalamazoo Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49444

Trinity Health Muskegon Hospital, Muskegon

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49519

University of Michigan Health - West, Wyoming

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50314

Mercy Medical Center - Des Moines, Des Moines

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

Aurora Saint Luke's South Shore, Cudahy

53142

Aurora Cancer Care-Kenosha South, Kenosha

53149

ProHealth D N Greenwald Center, Mukwonago

53188

UW Cancer Center at ProHealth Care, Waukesha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54806

Duluth Clinic Ashland, Ashland

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

54911

ThedaCare Regional Cancer Center, Appleton

55072

Essentia Health Sandstone, Sandstone

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55407

Abbott-Northwestern Hospital, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55746

Essentia Health Hibbing Clinic, Hibbing

55792

Essentia Health Virginia Clinic, Virginia

55805

Essentia Health Cancer Center, Duluth

56636

Essentia Health - Deer River Clinic, Deer River

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60123

Advocate Sherman Hospital, Elgin

60429

Advocate South Suburban Hospital, Hazel Crest

60504

Rush-Copley Medical Center, Aurora

60515

Advocate Good Samaritan Hospital, Downers Grove

60560

Rush-Copley Healthcare Center, Yorkville

60612

University of Illinois, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

63703

Saint Francis Medical Center, Cape Girardeau

70121

Ochsner Medical Center Jefferson, New Orleans

70433

Ochsner Hematology Oncology North Shore - Covington (West Region), Covington

70805

LSU Health Baton Rouge-North Clinic, Baton Rouge

70808

Our Lady of the Lake Physician Group, Baton Rouge

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

75080

UT Southwestern Clinical Center at Richardson/Plano, Richardson

75237

UT Southwestern Simmons Cancer Center - RedBird, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

UT Southwestern/Simmons Cancer Center-Fort Worth, Fort Worth

77030

M D Anderson Cancer Center, Houston

79106

The Don and Sybil Harrington Cancer Center, Amarillo

80045

UCHealth University of Colorado Hospital, Aurora

80129

UCHealth Highlands Ranch Hospital, Highlands Ranch

80524

Poudre Valley Hospital, Fort Collins

80528

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

Medical Center of the Rockies, Loveland

80631

UCHealth Greeley Hospital, Greeley

80907

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80909

UCHealth Memorial Hospital Central, Colorado Springs

80920

Memorial Hospital North, Colorado Springs

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

Saint Luke's Cancer Institute - Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85338

CTCA at Western Regional Medical Center, Goodyear

92612

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93720

Kaiser Permanente-Fresno, Fresno

94080

Kaiser Permanente-South San Francisco, South San Francisco

94115

Kaiser Permanente-San Francisco, San Francisco

94538

Kaiser Permanente-Fremont, Fremont

94568

Kaiser Permanente Dublin, Dublin

94577

Kaiser Permanente San Leandro, San Leandro

94589

Kaiser Permanente-Vallejo, Vallejo

94596

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

Kaiser Permanente-Oakland, Oakland

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95356

Kaiser Permanente-Modesto, Modesto

95403

Kaiser Permanente-Santa Rosa, Santa Rosa

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95661

Kaiser Permanente-Roseville, Roseville

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95814

Kaiser Permanente Downtown Commons, Sacramento

95816

Mercy Cancer Center - Sacramento, Sacramento

95823

Kaiser Permanente-South Sacramento, Sacramento

96819

Kaiser Permanente Moanalua Medical Center, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98122

Swedish Medical Center-First Hill, Seattle

60453-2699

Advocate Christ Medical Center, Oak Lawn

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08822

Hunterdon Medical Center, Flemington

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

02903

Rhode Island Hospital, Providence

05819

Dartmouth Cancer Center - North, Saint Johnsbury

00961

Puerto Rico Hematology Oncology Group, Bayamón

00927

Centro Comprensivo de Cancer de UPR, San Juan

PROncology, San Juan

00936

San Juan City Hospital, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH