Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease

Auto-Refractometry / Adaptative Optics (OA) / Swept Source Optical Coherence Tomography (SS-OCT-A) / Globe Axial length measurements / Color Retinophotography of the retina.

Analyses of molecular biomarkers including

Measurement of blood pressure and arterial stiffness

3DT1 / 3DFLAIR / T2GRE / DTI 15 directions (and B0MAP)

Mini Mental State Examination (MMSE) / Montreal Cognitive Assessment (MoCA) / 16 items Free and Cued Recall (RL/RI 16 items) / Trail Making Test A et B (TMT A et B) / Frontal Assessment Battery (FAB) / Phonemic (letter P) and semantic (animals) verbal fluency tests / Digit Symbol Substitution Test (DSST)

15 items

Instrumental Activities of Daily Living (IADL)

Unipodal standing test

over 5 meters