32
Participants
Start Date
October 5, 2022
Primary Completion Date
February 1, 2025
Study Completion Date
July 1, 2028
Ponatinib
Ponatinib is a novel, synthetic, orally-active TKI discovered using a computational and structure based drug design approach. Ponatinib was specifically designed to inhibit all clinically relevant variants of BCR-ABL1, including the T315I mutant (15-17). In vitro assays have demonstrated that Ponatinib potently inhibits the kinase enzymatic activity of the T315I ABL kinase domain, as well as that of the native (unmutated) enzyme. In leukemia cell lines expressing these BCR-ABL1 variants, Ponatinib potently inhibited BCR-ABL1 signaling, leading to the reduction of cellular proliferation and induction of apoptosis. Ponatinib also inhibits the proliferation of cell lines expressing other major clinically-observed Imatinib-resistant mutants of BCR-ABL1.
RECRUITING
Ematologia con Unità di Trapianto, Avellino
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Ematologia Presidio Ospedaliero Tortora, Pagani
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Ematologia ASST Papa Giovanni XXIII, Bergamo
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Ematologia AOU S.ORSOLA-MALPIGHI, Bologna
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Ematologia ASST Spedali Civili, Brescia
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Ematologia AOU Policlinico Vittorio Emanuele-Ferrarotto, Catania
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Ematologia AOU Careggi, Florence
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Ematologia Ospedale V.Fazzi, Lecce
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Ematologia Ospedale dell'Angelo, Mestre
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Ematologia Ospedale Maggiore Policlinico, Milan
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Ematologia AOU Federico II, Napoli
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Ematologia AOU Maggiore della Carità, Novara
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Ematologia AO Ospedali Riuniti Villa Sofia Cervello, Palermo
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Ematologia Fondazione Policlinico San Matteo, Pavia
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Ematologia Presidio Ospedaliero Spirito Santo, Pescara
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Ematologi Presidio Ospedaliero Guglielmo da Saliceto, Piacenza
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Ematologia Presidio Ospedaliero Infermi, Rimini
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Dipartimento di Medicina Traslazionale e di Precisione - Ematologia, Roma
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Ematologia AOU Policlinico Tor Vergata, Roma
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Ematologia Policlinico A.Gemelli, Roma
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Ematologia AOU Senese, Siena
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Ematologia Ospedale Mauriziano, Torino
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Ematologia Ospedale S.Giovanni Battista Molinette, Torino
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Ematologia Policlinico G.B. Rossi, Verona
Gruppo Italiano Malattie EMatologiche dell'Adulto
OTHER