Testing the Combination of Inotuzumab Ozogamicin and Lower Dose Chemotherapy Compared to Usual Chemotherapy for Adults With B-Cell Acute Lymphoblastic Leukemia or B-Cell Lymphoblastic Lymphoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

68

Participants

Timeline

Start Date

June 9, 2023

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2028

Conditions
B Acute Lymphoblastic LeukemiaB Lymphoblastic Lymphoma
Interventions
DRUG

Cyclophosphamide

Given IV

DRUG

Vincristine

Given IV

DRUG

Dexamethasone

Given IV or PO

BIOLOGICAL

Inotuzumab Ozogamicin

Given IV

DRUG

Methotrexate

Given IV or PO

DRUG

Cytarabine

Given IV

DRUG

Methylprednisolone

Given IV

BIOLOGICAL

Rituximab

Given IV

DRUG

Prednisone

Given PO

DRUG

Mercaptopurine

Given PO

DRUG

Doxorubicin

Given IV

Trial Locations (72)

10029

Mount Sinai Hospital, New York

11030

North Shore University Hospital, Manhasset

11042

Northwell Health/Center for Advanced Medicine, Lake Success

14642

University of Rochester, Rochester

17822

Geisinger Medical Center, Danville

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19107

Thomas Jefferson University Hospital, Philadelphia

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

23298

Virginia Commonwealth University/Massey Cancer Center, Richmond

26506

West Virginia University Healthcare, Morgantown

29425

Medical University of South Carolina, Charleston

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

35233

University of Alabama at Birmingham Cancer Center, Birmingham

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

40207

Norton Suburban Hospital and Medical Campus, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

53226

Medical College of Wisconsin, Milwaukee

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Medical Center - Minocqua, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Logan Health Medical Center, Kalispell

60026

NorthShore University HealthSystem-Glenbrook Hospital, Glenview

60035

NorthShore University HealthSystem-Highland Park Hospital, Highland Park

60153

Loyola University Medical Center, Maywood

60201

NorthShore University HealthSystem-Evanston Hospital, Evanston

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

62269

Memorial Hospital East, Shiloh

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

87106

University of New Mexico Cancer Center, Albuquerque

92612

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

94304

Stanford Cancer Institute Palo Alto, Palo Alto

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97239

Oregon Health and Science University, Portland

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

06520

Yale University, New Haven

02215

Dana-Farber Cancer Institute, Boston

05401

University of Vermont Medical Center, Burlington

05405

University of Vermont and State Agricultural College, Burlington

00936

San Juan City Hospital, San Juan

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER