Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia

NARecruitingINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

September 2, 2022

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Stroke, IschemicAphasia Non Fluent
Interventions
DEVICE

Noninvasive transcranial brain stimulation: excitatory iTBS

600 pulses (3 pulses at 50 Hz given every 200 milliseconds in 2-second trains at 10-second intervals, delivered at 80% of active motor threshold) generated by Magstim Super Rapid2 stimulator equipped with a figure-of-eight coil applied over BA 45 Device: Magstim Co., Wales, UK.

DEVICE

Noninvasive transcranial brain stimulation: inhibitory cTBS

600 pulses (3 pulses at 50 Hz, repeated at 5 Hz, delivered at 80% of active motor threshold) generated by Magstim Super Rapid2 stimulator equipped with a figure-of-eight coil applied over BA 45 homologue Device: Magstim Co., Wales, UK.

BEHAVIORAL

Individual speech-language therapy (SLT)

45 minutes training tailored to every patient's deficits, abilities and needs. Exercises used during each therapeutic session include: expressions tasks (naming and sentence building), complex utterances comprehension tasks, reading and writing exercises. Training is administered using paper-and-pencil tasks and computerized aphasia therapy program AfaSystem (Harpo sp.zoo, Poznań, Poland).

DEVICE

Sham TBS simulating left hemispheric iTBS

Sham TMS coil positioned exactly like an active TMS coil resulting in a very good approximation of the auditory effects Device: Magstim Co., Wales, UK.

Trial Locations (1)

Unknown

RECRUITING

Institute of Psychiatry and Neurology, Warsaw

All Listed Sponsors
lead

Institute of Psychiatry and Neurology, Warsaw

OTHER