EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

6,019

Participants

Timeline

Start Date

October 26, 2022

Primary Completion Date

May 29, 2027

Study Completion Date

May 29, 2027

Conditions
Cardiovascular DiseaseMyocardial InfarctionStrokeCoronary Revascularization
Interventions
DRUG

Evolocumab

Evolocumab will be provided as a single-dose, prefilled autoinjector pen (AI/pen) for fixed dose subcutaneous (SC) injection.

DRUG

Routine Lipid Management

Routine lipid management therapies will be administered at the discretion of the investigator per SoC.

Trial Locations (120)

10065

New York Presbyterian-Weill Cornell Medical Center, New York

10310

Richmond University Medical Center, Staten Island

10580

Montefiore Medical Center, The Bronx

11706

South Shore University Hospital Northwell Health, Bay Shore

11794

Stony Brook Medicine, Stony Brook

12601

Hudson Valley Cardiovascular Practice PC, Poughkeepsie

14642

University of Rochester Medical Center, Rochester

17201

Wellspan Chambersburg Hospital, Chambersburg

17603

Lancaster General Hospital/The Heart Group of Lancaster, Lancaster

19611

Reading Hospital Tower Health, West Reading

23114

Bon Secours St Marys Hospital Richmond, Midlothian

23225

Chippenham Hospital, Richmond

27401

Moses H Cone Memorial Hospital, Greensboro

27599

University of North Carolina Cardiology, Chapel Hill

28204

Novant Health Heart and Vascular Institute Presbyterian Medical Center, Charlotte

29203

Prisma Upstate and Midlands Greenville Hospital System, Columbia

29607

Upstate Cardiology, Greenville

32209

University of Florida and Shands Hospital, Jacksonville

32501

Baptist Health Care, Pensacola

32504

Ascension Sacred Heart, Pensacola

32610

University of Florida at Gainesville, Gainesville

32789

Clinical Site Partners Orlando dba Flourish Research, Winter Park

32803

AdventHealth Orlando, Orlando

33410

Cardiology Partners Clinical Research Institute, Palm Beach Gardens

33434

Excel Medical Clinical Trials, Boca Raton

33614

Tampa Cardiovascular Interventions and Research, Tampa

33756

Clearwater Cardiovascular Consultants, Clearwater

34695

Clearwater Cardiovascular Consultants, Safety Harbor

35294

University of Alabama at Birmingham, Birmingham

36532

Eastern Shore Research Institute, Fairhope

37205

Ascension Saint Thomas Nashville, Nashville

37830

Parkway Cardiology Associates, Oak Ridge

37849

Cardiovascular Research of Knoxville North Knoxville Medical Center, Powell

37934

Tennova Healthcare-Turkey Creek Medical Center, Knoxville

38801

Cardiology Associates of North Mississippi, Tupelo

39216

Jackson Heart, Jackson

40202

University of Louisville Health - Jewish Hospital, Louisville

43210

The Ohio State University Wexner Medical Center, Columbus

43701

Genesis Healthcare System, Zanesville

44710

Aultman Hospital, Canton

46290

Ascension Saint Vincent Heart Center, Indianapolis

47374

Reid Physician Associates, Richmond

48043

McLaren Macomb Research Services, Mount Clemens

48202

Henry Ford Hospital, Detroit

48307

Advanced Cardiology Associates, Rochester Hills

48912

Sparrow Clinical Research Institute, Lansing

49546

Healthy Heart Cardiology, Grand Rapids

49770

McLaren Northern Michigan Hospital, Petoskey

53215

Aurora Saint Lukes Medical Center, Milwaukee

55805

Essentia Health Saint Marys Medical Center, Duluth

60068

Advocate Lutheran General Hospital, Park Ridge

60612

Jesse Brown Veterans Affairs Medical Center, Chicago

60640

Great Lakes Clinical Trials - Ravenswood, Chicago

64111

Saint Lukes Hospital of Kansas City, Kansas City

64116

North Kansas City Hospital, North Kansas City

66160

University of Kansas Hospital, Kansas City

66211

Midwest Heart and Vascular Specialists, Overland Park

74104

Ascension Saint John Bartlesville, Tulsa

Ascension Saint John Tulsa, Tulsa

78640

Ascension Texas Cardiovascular Kyle, Kyle

78705

Ascension Texas Cardiovascular, Austin

80045

University of Colorado Hospital, Aurora

83712

Saint Lukes Boise Medical Center, Boise

85258

Scottsdale Healthcare at Shea - HonorHealth, Scottsdale

85719

Pima Heart and Vascular Clinical Research, Tucson

86001

Northern Arizona Healthcare Corporation Cardiovascular Institute, Flagstaff

90073

VA Greater Los Angeles Healthcare System, Los Angeles

90095

University of California Los Angeles, Los Angeles

92868

University of California-Irvine, Orange

94520

John Muir Health and Cardiovascular Institute, Concord

29900010

Instituto Cardiovascular de Linhares, Linhares

69900785

Clínica Silvestre Sante, Rio Branco

35801-4317

Heart Center Research LLC, Huntsville

06610

Bridgeport Hospital, Bridgeport

06106

Hartford Hospital, Hartford

06905

Cardiology Associates of Fairfield County PC, Stamford

02114

Massachusetts General Hospital, Boston

08807

Advanced Heart Care LLC, Bridgewater

07601

Hackensack University Medical Center, Hackensack

07102

Saint Michaels Medical Center, Newark

02903

Rhode Island Hospital, Providence

02886

Kent Hospital, Warwick

37232-8802

Vanderbilt University Medical Center, Nashville

74453-200

Hospital Ruy Azeredo, Ipiranga Goiânia

Hospital Universitario Sao Francisco na Providencia de Deus, Ipiranga Goiânia

30140-073

Hospital Madre Teresa, Belo Horizonte

Hospital Universitário Ciências Médicas de Belo Horizonte, Belo Horizonte

37706-106

Hospital do Coracao de Pocos de Caldas CEC servicos medicos, Poços de Caldas

52061-540

Ps Cardiologico de PE - Procape, Casa Forte

59020-500

Instituto Atena de Pesquisa Clínica, Natal

90035-001

Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento, Porto Alegre

90035-903

Hospital de Clínicas de Porto Alegre, Porto Alegre

90620-001

Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre

Santa Casa de Porto Alegre, Porto Alegre

90840-440

Hospital Mãe de Deus, Porto Alegre

Irmandade da Santa Casa de Misericordia de Marilia, Marília

01323-900

Hospital Beneficência Portuguesa, São Paulo

89204-250

Cmep-Centro Multidisciplinar Ensino e Pesq, Joinville

88103-450

Instituto de Cardiologia de Santa Catarina, Praia Comprida, Sao Jose

49055-530

Centro de Pesquisa Clinica do Coracao, Aracaju

13060-080

Instituto de Pesquisa Clínica de Campinas, Campinas

19050-680

Hospital Regional de Presidente Prudente, Presidente Prudente

04012-909

Instituto Dante Pazanesse, São Paulo

05403-000

Instituto do coracao da Faculdade de Medicina da Universidade de Sao Paulo - InCor, São Paulo

05652-900

Hospital Israelita Albert Einstein, São Paulo

441 33

Alingsas Lasarett, Alingsås

801 88

Gavle Sjukhus, Gävle

553 05

Lanssjukhuset Ryhov, Jönköping

371 85

Blekingesjukhuset Karlskrona, Karlskrona

581 85

Linkoping University Hospital, Linköping

971 80

Sunderby Sjukhus, Luleå

221 85

Skane Universitetssjukhus i Lund, Lund

431 80

Molndals Sjukhus, Molndahl

601 82

Vrinnevisjukhuset, Norrkoeping, Norrköping

831 83

Ostersunds sjukhus, Östersund

118 83

Sodersjukhuset, Stockholm

851 86

Sundsvalls Sjukhus, Sundsvall

751 85

Akademiska Sjukhuset i Uppsala, Uppsala

351 85

Centrallasarettet Vaxjo, Vaxjo

721 89

Vastmanlands Sjukhus Vasteras, Västerås

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Colorado Prevention Center

OTHER

lead

Amgen

INDUSTRY

NCT05284747 - EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction | Biotech Hunter | Biotech Hunter