NCT05281471 - Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076) | Biotech Hunter

Enrollment

186

Participants

Timeline

Start Date

August 31, 2022

Primary Completion Date

June 30, 2026

Study Completion Date

October 31, 2026

Conditions

Platinum-resistant Ovarian CancerPlatinum-refractory Ovarian CancerFallopian Tube CancerPrimary Peritoneal CancerHigh-grade Serous Ovarian CancerEndometrioid Ovarian CancerOvarian Clear Cell Carcinoma

Interventions

BIOLOGICAL

olvimulogene nanivacirepvec

Olvi-Vec is an engineered oncolytic vaccinia virus

DRUG

Platinum chemotherapy: carboplatin (preferred) or cisplatin

Administered according to local practice

DRUG

Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane (paclitaxel, docetaxel or nab-paclitaxel) or pegylated liposomal doxorubicin

Administered according to local practice

DRUG

Bevacizumab (or biosimilar)

Administered according to local practice

Trial Locations (30)

11794

RECRUITING

Stony Brook Cancer Center, Stony Brook

15224

RECRUITING

AHN West Penn Hospital, Pittsburgh

20910

RECRUITING

Holy Cross Hospital, Silver Spring

27834

RECRUITING

East Carolina University, Greenville

28204

RECRUITING

Levine Cancer Institute, Charlotte

29425

RECRUITING

Hollings Cancer Center, Charleston

32804

RECRUITING

AdventHealth Cancer Institute, Orlando

34239

RECRUITING

Sarasota Memorial Research Institute, Sarasota

36604

RECRUITING

The University of South Alabama, Mitchell Cancer Institute, Mobile

37403

RECRUITING

Erlanger Health, Inc., Chattanooga

43214

RECRUITING

OhioHealth Research Institute, Columbus

43560

RECRUITING

ProMedica Flower Hospital, Sylvania

44195

RECRUITING

Cleveland Clinic, Cleveland

45429

RECRUITING

Kettering Health, Kettering

46202

RECRUITING

Indiana University Simon Comprehensive Cancer Center, Indianapolis

48109

RECRUITING

University of Michigan, Ann Arbor

48201

RECRUITING

Karmanos Cancer Institute, Detroit

63110

RECRUITING

Washington University School of Medicine, St Louis

63141

RECRUITING

Mercy Hospital St. Louis, St Louis

73104

RECRUITING

Oklahoma University Health Stephenson Cancer Center, Oklahoma City

77030

RECRUITING

Baylor College of Medicine, Houston

RECRUITING

University of Texas Science Center at Houston, McGovern Medical School, Houston

85719

RECRUITING

University of Arizona Cancer Center, Tucson

89106

RECRUITING

Women's Cancer Center of Nevada, Las Vegas

89511

RECRUITING

Center of Hope, Reno

91010

RECRUITING

City of Hope, Duarte

92093

RECRUITING

UC San Diego Health - Moores Cancer Center, La Jolla

92663

RECRUITING

Hoag Gynecologic Oncology, Newport Beach

92868

RECRUITING

UCI Health Chao Family Comprehensive Cancer Center, Orange

99204

RECRUITING

Providence Sacred Heart Medical Center & Children's Hospital, Spokane