NCT05279898View on ClinicalTrials.gov

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

NACompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

February 28, 2023

Primary Completion Date

June 30, 2024

Study Completion Date

December 31, 2024

Conditions
Postoperative DeliriumHemodynamic InstabilityPainNeurocognitive Dysfunction
Interventions
DEVICE

EEG Monitoring

Perioperative monitoring, MMGA guided by EEG for intervention group

DRUG

Ropivacaine

Intraoperative bilateral PIFB block with 20 mL of 0.2% Ropivicaine on either side of the sternum after anesthetic induction but before surgical incision (total of 40mL) PIFB on postoperative day 1 (provided they are extubated or getting ready to be extubated) to help with mobilization (for intervention group)

DRUG

Ketamine

Intraoperative infusion

DRUG

Remifentanil

Intraoperative infusion

DRUG

Dexmedetomidine

Intraoperative infusion

DRUG

Rocuronium

Intraoperative intermittent bolus

DRUG

Propofol

Intraoperative infusion

Trial Locations (1)

02115

Beth Israel Deaconess Medical Center, Boston

All Listed Sponsors
lead

Beth Israel Deaconess Medical Center

OTHER