NCT05275751View on ClinicalTrials.gov

Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

51

Participants

Timeline

Start Date

June 13, 2022

Primary Completion Date

November 30, 2022

Study Completion Date

November 30, 2022

Conditions
Pain
Interventions
DRUG

TRPA1-inhibitor

Pharmacological inhibition of TRPA1 during intradermal injection of hot synthetic interstitial fluid

DRUG

TRPV1-inhibitor

Pharmacological inhibition of TRPV1 during intradermal injection of hot synthetic interstitial fluid

DRUG

TRPM3-inhibitor

Pharmacological inhibition of TRPM3 during intradermal injection of hot synthetic interstitial fluid

DRUG

Placebo

No pharmacological intervention

DRUG

Chloride-channel inhibitor

Pharmacological inhibition of a chloride channel during intradermal injection of hot synthetic interstitial fluid

Trial Locations (1)

1090

Medical University of Vienna, Vienna

All Listed Sponsors
lead

Medical University of Vienna

OTHER