815
Participants
Start Date
May 2, 2022
Primary Completion Date
March 31, 2027
Study Completion Date
May 2, 2035
Encorafenib and Binimetinib
Encorafenib 450 mg (6 × 75 mg capsules) once daily (QD) and binimetinib 45 mg (3 x 15 mg tablets) twice daily (BID) orally for a maximum of 12 months.
Placebo to match Encorafenib ; Placebo to match Binimetinib
Encorafenib (6 × 75 mg placebo capsules) QD and binimetinib (3 × 15 mg placebo tablets) BID placebos orally for a maximum of 12 months.
Institut Jules Bordet, Anderlecht
Semmelweis Egyetem, Budapest
AKH - Medizinische Universität Wien, Vienna
Universitair Ziekenhuis Brussel, Brussels
Orszagos Onkologiai Intezet, Budapest
Cliniques Universitaires Saint-Luc, Brussels
Johese Clinical Research: Midstream, Centurion
Sanatorio Britanico S.A., Rosario
ZNA Middelheim, Antwerp
Melanoma Institute Australia, Wollstonecraft
Westmead Hospital, Sydney
ZNA, Merksem
Sandton Oncology Medical Group, Johannesburg
Austin Health, Heidelberg
Universitätsklinikum St.Pölten-Lilienfeld, Sankt Pölten
Box Hill Hospital, Box Hill
The Alfred Hospital, Prahran
Krankenhaus der Elisabethinen Linz, Linz
Debreceni Egyetem, Debrecen
Princess Alexandra Hospital, Woolloongabba
Adelaide Oncology & Haematolog, Calvary North Adelaide Hospital, North Adelaide
CHU UCL Namur, Yvoir
Hollywood Private Hospital, Nedlands
Sir Charles Gairdner Hospital, Nedlands
Ålesund Hospital, Ålesund
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Szeged
Pecsi Tudomanyegyetem, Pécs
Landeskrankenhaus - Universitaetsklinikum Graz, Graz
Universitaetsspital Zuerich, Zurich
UZ Gent, Ghent
Petz Aladar Egyetemi Oktato Korhaz, Győr
Vitaz, Sint-Niklaas
National Hospital Oncology, Bloemfontein
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino
"Clinical Center Bezanijska kosa", Belgrade
Institute of Oncology and Radiology of Serbia, Belgrade
Military Medical Academy, Belgrade
General Hospital of Athens Laiko, Athens
Azienda Sanitaria Ospedaliera S.Croce e Carle, Cuneo
Hôpital de la Timone, Marseille
Hospital Universitario Reina Sofia, Córdoba
IRCCS Ospedale Policlinico San Martino, Genova
Karolinska University Hospital, Stockholm
Clinical Center Nis, Niš
Metropolitan Hospital, Neo Faliro
Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
IEO Istituto Europeo di Oncologia, Milan
Universitaetsklinikum Hamburg-Eppendorf, Hamburg
CHU de Dijon - Hôpital du Bocage, Dijon
Oncology Institute of Vojvodina, Kamenitz
Elbekliniken Buxtehude GmbH, Buxtehude
Universitaetsklinikum Schleswig-Holstein, Kiel
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo
Hospital General Universitario Gregorio Marañon, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Hospital Universitario 12 de Octubre, Madrid
Centro Integral Oncologico Clara Campal, Madrid
Hospital Regional Universitario de Malaga, Málaga
Hospital Universitario Virgen de la Arrixaca, El Palmar
Institut Claudius Regaud - Oncopole, Toulouse
CHU de Bordeaux - Hôpital Saint André, Bordeaux
IRCCS Centro di Riferimento Oncologico, Aviano
Azienda Sanitaria Universitaria Friuli Centrale, Udine
Clinical Center Kragujevac, Kragujevac
CRLCC Eugene Marquis, Rennes
IOV - Istituto Oncologico Veneto IRCCS, Padua
CHU Tours - Hôpital Trousseau, Chambray-lès-Tours
CHU de Grenoble - Hôpital André Michallon, La Tronche
CHU Saint Etienne - Hôpital Nord, Saint-Étienne-de-Montluc
CHU Nantes - Hôtel Dieu, Nantes
Hospital Clinico Universitario de Valencia, Valencia
Hospital General Universitario de Valencia, Valencia
"IRCCS Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori Dino Amadori - IRST", Meldola
A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena
Bioclinic Thessaloniki, Thessaloniki
"Anticancer Hospital of Thessaloniki Theagenio", Thessaloniki
Azienda Ospedaliero Universitaria Pisana, Pisa
Interbalkan Hospital of Thessaloniki, Thessaloniki
Hopital Claude Huriez - CHU Lille, Lille
CAC Clermont-Ferrand Centre Jean Perrin, Clermont-Ferrand
Centre Hospitalier de Pau - Hôpital François Mitterrand, Pau
Universitaetsklinikum Heidelberg, Heidelberg
Centre Hospitalier Lyon Sud, Pierre-Bénite
Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari, Bari
Hôpital Saint-Louis, Paris
CHU de Rouen - Hôpital Charles Nicolle, Rouen
Fakultni nemocnice Olomouc, Olomouc
Istituto Nazionale Tumori Fondazione G. Pascale, Naples
CHU Poitiers - Hôpital la Milétrie, Poitiers
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone, Palermo
Hôpital Ambroise Paré, Boulogne-Billancourt
Institut Gustave Roussy, Villejuif
Universitaetsklinikum Wuerzburg, Würzburg
Ospedale San Vincenzo, Taormina
S.C Centrul de Oncologie Sf. Nectarie S.R.L, Craiova
S.C Medisprof S.R.L, Cluj-Napoca
Institutul Regional de Oncologie Iasi, Iași
Centro Oncologico Korben, CABA
Centro de Investigaciones Medicas Mar del Plata, Mar del Plata
Fundacion CIDEA, Ciudad Autonoma Bs As
Instituto de Oncologia de Rosario, Rosario
Hospital Aleman, Ciudad Autonoma Buenos Aires
Instituto Medico Especializado Alexander Fleming, Ciudad Autonoma Buenos Aires
Clinica Adventista Belgrano, Ciudad Autonoma Buenos Aires
AMO - Assistência Multidisciplinar em Oncologia, Salvador
Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba
Instituto de Cancer de Londrina, Londrina
Hospital de Clínicas de Porto Alegre, Porto Alegre
HGB - Hospital Giovanni Battista - Mãe de Deus Center, Porto Alegre
Instituto de Oncologia Saint Gallen, Santa Cruz do Sul
CEPON - Centro de Pesquisas Oncológicas de Santa Catarina, Florianópolis
Fundação Doutor Amaral Carvalho, Jaú
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André
A. C. Camargo Cancer Center, São Paulo
London Health Sciences Centre (LHSC) - Victoria Hospital, London
Toronto Sunnybrook Hospital, Toronto
Princess Margaret Cancer Centre, Toronto
CIUSSS du Centre Ouest de l'lle de Montreal, Montreal
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultni nemocnice Ostrava, Ostrava - Poruba
Fakultni nemocnice Kralovske Vinohrady, Prague
Vseobecna fakultni nemocnice v Praze, Prague
CHU Nice - Hopital de l Archet 2, Nice
Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden
Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia, Perugia
Istituto Nazionale Tumori Regina Elena IRCCS, Roma
IDI-Istituto Dermopatico dell'Immacolata IRCCS, Roma
Policlinico Universitario di Sassari, Sassari
Antoni van Leeuwenhoek, Amsterdam
Universitair Medisch Centrum Groningen (UMCG), Groningen
Leids Universitair Medisch Centrum, Leiden
Maastricht University Medical Center, Maastricht
Radboudumc, Nijmegen
Erasmus MC, Rotterdam
UMC Utrecht, Utrecht
Isala, Zwolle
Oslo University Hospital, Oslo
Narodowy Instytut Onkologii im. M. Sklodowskiej-Curie - Panstwowy Instytut Badawczy, Gliwice
Przychodnia Lekarska Komed, Konin
Centrum Onkologii-Instytut im. M. Sklodowskiej-Curie, Krakow
Wielkopolskie Centrum Onkologii, Poznan
Centrum Medyczne Pratia Poznan, Skórzewo
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Warsaw
Dolnoslaskie Centrum Onkologii, Wroclaw
Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Lisbon
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Norrlands Universitetssjukhus, Umeå
Royal Preston Hospital, Preston
Northern Centre for Cancer Care, Newcastle upon Tyne
European Organisation for Research and Treatment of Cancer - EORTC
NETWORK
Pierre Fabre Medicament
INDUSTRY