Changes in Cardiac Output During Cesarean Delivery Under Spinal Anesthesia

CompletedOBSERVATIONAL
Enrollment

60

Participants

Timeline

Start Date

March 12, 2022

Primary Completion Date

July 2, 2022

Study Completion Date

July 2, 2022

Conditions
Anesthesia, SpinalCesarean SectionEchocardiographyCardiac Output
Interventions
RADIATION

Transthoracic Echocardiography

Measurement of cardiac output in supine position with left lateral tilt at baseline, at 10 minutes after intrathecal injection, immediately after delivery, and at 1 hour after intrathecal injection

PROCEDURE

Spinal Anesthesia

Performed at the L3-L4 or L4-L5 interspace using 25-gauge spinal needle

DRUG

Intrathecal Bupivacaine

Bupivacaine 12.5 mg (2.5 mL 0.5%) will be administered in the subarachnoid space

DRUG

Intrathecal Fentanyl

Fentanyl 15 μg will be administered in the subarachnoid space

DRUG

Crystalloid Coload 1000 mL

Ringer acetate 1000 mL will be administered over 10 minutes starting immediately after intrathecal injection

PROCEDURE

Cesarean Delivery

Lower segment cesarean section using the Pfannenstiel incision and uterine exteriorization

DRUG

Intravenous Ephedrine

Intravenous ephedrine 3, 5, and 10 mg will be administered when Systolic blood pressure decreases below 90%, 80%, and 70% of baseline, respectively.

DRUG

Oxytocin

Intravenous oxytocin 10 U in 500 mL Ringer acetate will be administered over 30 minutes starting immediately after delivery of the fetus

Trial Locations (1)

35516

Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals, Al Mansurah

All Listed Sponsors
lead

Mansoura University

OTHER