60
Participants
Start Date
March 12, 2022
Primary Completion Date
July 2, 2022
Study Completion Date
July 2, 2022
Transthoracic Echocardiography
Measurement of cardiac output in supine position with left lateral tilt at baseline, at 10 minutes after intrathecal injection, immediately after delivery, and at 1 hour after intrathecal injection
Spinal Anesthesia
Performed at the L3-L4 or L4-L5 interspace using 25-gauge spinal needle
Intrathecal Bupivacaine
Bupivacaine 12.5 mg (2.5 mL 0.5%) will be administered in the subarachnoid space
Intrathecal Fentanyl
Fentanyl 15 μg will be administered in the subarachnoid space
Crystalloid Coload 1000 mL
Ringer acetate 1000 mL will be administered over 10 minutes starting immediately after intrathecal injection
Cesarean Delivery
Lower segment cesarean section using the Pfannenstiel incision and uterine exteriorization
Intravenous Ephedrine
Intravenous ephedrine 3, 5, and 10 mg will be administered when Systolic blood pressure decreases below 90%, 80%, and 70% of baseline, respectively.
Oxytocin
Intravenous oxytocin 10 U in 500 mL Ringer acetate will be administered over 30 minutes starting immediately after delivery of the fetus
Department of Anesthesia and Surgical Critical Care, Mansoura University Hospitals, Al Mansurah
Mansoura University
OTHER