Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

197

Participants

Timeline

Start Date

December 22, 2021

Primary Completion Date

April 30, 2028

Study Completion Date

July 31, 2028

Conditions
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Interventions
DRUG

E2814

Administered intravenously in a blinded fashion

DRUG

Lecanemab

Administered intravenously

DRUG

Matching Placebo (E2814)

Placebo administered intravenously in a blinded fashion.

Trial Locations (38)

2031

Neuroscience Research Australia, Randwick

3010

Mental Health Research Institute, Melbourne

8036

Hospital Clínic I Provincial de Barcelona, Barcelona

14269

Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City

15213

University of Pittsburgh, Pittsburgh

25125

IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia

30329

Emory University, Atlanta

31059

CHU de Toulouse - Hôpital Purpan, Toulouse

35294

University of Alabama in Birmingham, Birmingham

46202

Indiana University School of Medicine, Indianapolis

50134

Azienda Ospedaliera Universitaria Careggi, Florence

59037

Hopital Roger Salengro - CHU Lille, Lille

60068

Advocate Lutheran General Hospital, Park Ridge

63110

Washington University in St. Louis, St Louis

69677

Groupe Hospitalier Pitie-Salpetriere, Paris

Hopital Neurologique Pierre Wertheimer, Bron

72076

Universitaetsklinikum Tubingen, Tübingen

75231

Kerwin Research Center,, Dallas

76031

CHU de Rouen - Hôpital Charles Nicolle, Rouen

81377

LMU-Campus Grosshadern, Munich

90033

USC Keck School of Medicine, Los Angeles

92037

University of California San Diego Medical Center, La Jolla

98195

University of Washington, Seattle

06510

Yale University School of Medicine, New Haven

02096

Butler Hospital, Providence

C1428AQK

Instituto de Investigaciones Neurologicas Raul Carrea, FLENI, Ciudad Autonoma de Buenos Aire

05403-000

Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo

V6T 2B5

UBC Hospital, Vancouver

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

H4H 1R3

McGill Center for Studies in Aging, Verdun

G1J 1Z4

CHU de Quebec - Hôpital de l' Enfant Jésus, Québec

Unknown

Grupo de Neurociencias Sede de la Universidad de Antioquia, Medellín

DUBLIN 4

St Vincent's University Hospital, Dublin

951-8520

Niigata University Medical & Dental Hospital, Niigata

113-8655

University of Tokyo Hospital, Bunkyō City

1081 GM

Brain Research Center, Amsterdam

00936

University of Puerto Rico, School of Medicine, San Juan

WC1B 3BG

The National Hospital for Neurology and Neurosurgery, London

All Listed Sponsors
collaborator

Alzheimer's Association

OTHER

collaborator

National Institute on Aging (NIA)

NIH

collaborator

Accelerating Medicines Partnership (AMP)

OTHER

collaborator

Eisai Inc.

INDUSTRY

lead

Washington University School of Medicine

OTHER