A Study of Itolizumab in Combination With Corticosteroids for the First-Line Treatment of Acute Graft Versus Host Disease (EQUATOR)

PHASE3TerminatedINTERVENTIONAL
Enrollment

158

Participants

Timeline

Start Date

April 29, 2022

Primary Completion Date

April 22, 2025

Study Completion Date

May 12, 2025

Conditions
Graft Versus Host DiseaseGVHDAcute-graft-versus-host DiseaseAcute GVHDaGVHD
Interventions
BIOLOGICAL

Itolizumab

Itolizumab \[Bmab600\]

DRUG

EQ001 Placebo

EQ001 Placebo

Trial Locations (118)

1023

Starship Children's Hospital, Auckland

1070

ULB - Institut Jules Bordet; department of Hematology, Anderlecht

1200

Cliniques Universitaires Saint-Luc; Hematology Department, Brussels

2060

ZNA Stuivenberg, Antwerp

2145

Westmead Hospital, Westmead

3000

UZ Leuven - Campus Gasthuisberg - Department of Hematology, Leuven

3002

Royal Melbourne Hospital, East Melbourne

3084

Austin Health, Heidelberg

4000

CHU de Liege - Hematology Department, Liège

5000

Royal Adelaide Hospital, Adelaide

8000

AZ Sint-Jan Brugge-Oostende AV, Bruges

8025

Hospital de la Santa Creu i Sant Pau, Barcelona

8800

AZ Delta, Roeselare

10065

David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center, New York

10126

AOU Citta della Salute e della Scienza di Torino - Ospedale Regina Margherita, Torino

11042

Northwell Health, Lake Success

11794

Stony Brook University Medical Center, Stony Brook

13009

Institut Paoli Calmettes - Hematology, Marseille

13353

Charité Universitätsmedizin Berlin, Tumorimmunologie Campus Virchow-Klinikum, Berlin

14003

CHU de Caen - Hopital Femme-Enfant-Hematologie (FEH), Caen

15232

University of Pittsburgh Medical Center (UPMC) - Hillman Cancer Center, Pittsburgh

18014

Hospital Universitario Virgen de las Nieves, Granada

19104

University of Pennsylvania Abramson Cancer Center, Philadelphia

20014

Hospital Universitario Donostia, Donostia / San Sebastian

20089

Istituto Clinico Humanitas, Rozzano

20132

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Milan

IRCCS Ospedale San Raffaele, Milan

20900

Fondazione IRCCS San Gerardo dei Tintori, Monza

21201

University of Maryland Medical Center, Baltimore

27157

Wake Forest, Winston-Salem

27514

University of North Carolina (UNC), Chapel Hill

28007

Hospital General Universitario Gregorio Maranon, Madrid

28034

Hospital Universitario Ramon y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28046

Clinica Universidad de Navarra - Pamplona, Madrid

Hospital Universitario La Paz, Madrid

Hospital Universitario Marques de Valdecilla, Madrid

29010

Hospital Universitario Regional de Málaga, Málaga

30322

Emory University, Atlanta

31059

CHU Toulouse, Hematology, Toulouse

32804

AdventHealth Orlando, Orlando

33604

CHU Bordeaux - Hopital Haut-Leveque - Centre François Magendie, Pessac

33612

Moffitt Cancer Center, Tampa

35033

CHU de Rennes Hôpital Pontchaillou, Rennes

35294

University of Alabama at Birmingham, Birmingham

37007

Hospital Clinico Universitario de Salamanca, Salamanca

37134

Azienda Ospedaliera - Universitaria Integrata di Verona - Ospedale Borgo Roma, Verona

37203

Sarah Cannon Research Institute, LLC (SCRI), Nashville

38043

CHU de Grenoble Hôpital Michallon, Grenoble

40138

Dipartimento Malattie oncologiche ed ematologiche - U.O. Ematologia - Programma dipartimentale Terapie cellulari avanzate, Bologna

40225

Universitaetsklinikum Duesseldorf, Düsseldorf

41013

Hospital Universitario Virgen del Rocio, Seville

41944

Kyungpook National University Hospital, Daegu

43201

The Ohio State University (OSU), Columbus

44106

University Hospitals Cleveland Medical Center, Cleveland

45242

Oncology Hematology in Cincinnati, Cincinnati

46010

Hospital Clínico Universitario de Valencia, Valencia

46026

Hospital Universitari i Politecnic La Fe, Valencia

48109

University of Michigan, Ann Arbor

48149

Universitätsklinikum Münster, Münster

48202

Henry Ford Hospital, Detroit

49241

Pusan National University Hospital, Busan

49503

Spectrum Health, Grand Rapids

50134

Azienda Ospedaliero-Universitaria Careggi, Florence

50937

Universitaetsklinikum Koeln (AoeR), Cologne

52242

University of Iowa, Iowa City

55905

Mayo Clinic - Rochester, Rochester

58128

Chonnam National University Hwasun Hospital, Hwasun

59000

CHU de Lille - Hopital Claude Huriez, Lille

60153

Loyola University Chicago, performing research at Loyola University Medical Center, Maywood

60611

Northwestern Memorial Hospital, Chicago

60637

The University of Chicago Medical Center (UCMC), Chicago

69003

CHU de Nantes - Hôtel-Dieu, Lyon

69495

HCL Centre Hospitalier Lyon Sud, Pierre-Bénite

70112

Tulane University Medical Center, New Orleans

75010

AP-HP Hopital Saint-Louis, Paris

75246

Baylor Scott & White Research Institute, Dallas

75390

UT Southwestern Medical Center, Dallas

80054

CHU Amiens Picardie - Hopital Sud, Amiens

89081

Universitaetsklinikum Ulm, Ulm

89133

"Grande Ospedale Metropolitano Bianchi Melacrino Morelli", Reggio Calabria

90033

University of Southern California, Los Angeles

90059

University of California, Los Angeles (UCLA) - Medical Center, Los Angeles

91010

City of Hope, Duarte

92093

University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla

94305

Stanford Cancer Center, Stanford

94805

Institut Gustave Roussy - Hematology, Villejuif

95123

Azienda Ospedaliero Universitaria Policlinico G. Rodolico-San Marco- Presidio Ospedaliero Ferrarotto Alessi, Catania

97080

Universitätsklinikum Würzburg, Medizinische Klinik II, Würzburg

97239

Oregon Health & Science University (OHSU), Portland

98109

Fred Hutchinson Cancer Research Center, Seattle

3109601

Rambam Health Care Campus, Haifa

4941492

Bone Marrow Transplantation Unit Rabin MC, Petah Tikva

5265601

Chaim Sheba Medical Center, Tel Litwinsky

6423906

Tel Aviv Sourasky Medical Center, Tel Aviv

9112001

Hadassah Medical Center Ein Karem, Jerusalem

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

07601

John Theurer Cancer Center At Hackensack UMC, Hackensack

08901

Rutgers Cancer Institute of NJ, New Brunswick

V5Z 1M9

Vancouver Coastal Health Authority, Vancouver

M5G 2M9

Princess Margaret Hospital, Toronto

H3G 1A4

McGill University Health Center - Research Institute, Montreal

G1R 2J6

CHU de Québec - Université Laval, Québec

S7N 4H4

University of Saskatchewan, Saskatoon

06200

CHU Nice, Hospital l'Archet, Nice

06120

Martin Luther Universitat Halle-Wittenberg, Halle

07747

Universitätsklinikum Jena, Jena

04103

Universitaetsklinikum Leipzig, Leipzig

00168

Fondazione Policlinico Universitario A. Gemelli IRCCS - Universita Cattolica del Sacro Cuore, Rome

1099-023

Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon

4200-072

Instituto Português de Oncologia do Porto Francisco Gentil, E.P.E., Porto

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08036

Hospital Clinic Barcelona, Barcelona

08908

Institut Catala d'Oncologia - L'Hospitalet, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Biocon Limited

INDUSTRY

lead

Equillium

INDUSTRY