A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

March 14, 2022

Primary Completion Date

August 23, 2026

Study Completion Date

August 23, 2026

Conditions
Breast CancerSolid Tumors
Interventions
DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07104091 + PF-07220060 + fulvestrant dose expansion

PF-07104091 and PF-07220060 will be administered orally in combination with fulvestrant

DRUG

PF-07104091 + PF-07220060 + fulvestrant dose expansion

PF-07104091 and PF-07220060 will be administered orally in combination with fulvestrant

DRUG

PF-07104091 + PF-07220060 + letrozole dose expansion

PF-07104091 and PF-07220060 will be administered orally in combination with letrozole

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

DRUG

PF-07220060 + PF-07104091 combination dose escalation

PF-07104091 and PF-07220060 will be administered orally

Trial Locations (51)

1303

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia

1426

Centro Oncologico Korben, Buenos Aires

1632

Multiprofile Hospital for Active Treatment Serdika EOOD, Sofia

2193

15 Eton Road, Johannesburg

Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg

WCR Office, Johannesburg

Wits Clinical Research, Johannesburg

3000

Complex Oncology Center - Vratsa, Vratsa

4004

Complex Oncology Center - Plovdiv EOOD, Plovdiv

6300

Specialized Hospital for Active Treatment of Oncology - Haskovo, Haskovo

9301

FARMOVS, Bloemfontein

12808

Vseobecna fakultni nemocnice v Praze, Prague

14080

Instituto Nacional de Cancerologia, Mexico City

15706

CHUS - Hospital Clinico Universitario, Santiago de Compostela

28041

Hospital Universitario 12 de Octubre, Madrid

28050

Hospital Universitario HM Sanchinarro, Madrid

41013

Hospital Universitario Virgen Del Rocio, Seville

49546

START Midwest, Grand Rapids

64111

Saint Luke's Cancer Institute, Kansas City

64460

"Hospital Universitario Dr. Jose Eleuterio Gonzalez", Monterrey

75246

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

77030

The University of Texas MD Anderson Cancer Center, Houston

90095

Administrative Address: UCLA Hematology/Oncology, Los Angeles

Ronald Reagan UCLA Medical Center, Los Angeles

UCLA Hematology/Oncology, Los Angeles

90404

UCLA Hematology / Oncology-Parkside, Santa Monica

UCLA Hematology/Oncology-Santa Monica, Santa Monica

97125

Mérida Investigación Clínica, Mérida

98104

Swedish Medical Center, Seattle

98122

Swedish Medical Center, Seattle

130021

The First Hospital of Jilin University, Changchun

200032

Fudan University Shanghai Cancer Center, Shanghai

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

310016

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou

Sir Run Run Shaw Hospital, Hangzhou

610041

West China Hospital of Sichuan University, Chengdu

West China Hospital, Sichuan University, Chengdu

14784400

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

02114

Massachusetts General Hospital, Boston

R8500ACE

Clinica Viedma S. A, Viedma

X50004FHP

Clínica Universitaria Reina Fabiola, Córdoba

F5300COE

Fundación CORI para la Investigación y Prevención del Cáncer, La Rioja

98700-000

ONCOSITE - Centro de Pesquisa Clinica em Oncologia, Ijuí

90110-270

Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa, Porto Alegre

90850-170

Centro de Pesquisa Clínica - Área Administrativa, Porto Alegre

01317-000

Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda, São Paulo

779 00

Fakultni nemocnice Olomouc, Olomouc

180 81

Fakultni nemocnice Bulovka, Prague

0040

Wilgers Oncology Centre, Pretoria

08035

Hospital Universitari Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY