A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL593 in Healthy Participants and Participants With Frontotemporal Dementia (FTD-GRN)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

106

Participants

Timeline

Start Date

February 1, 2022

Primary Completion Date

December 31, 2026

Study Completion Date

November 30, 2028

Conditions
Frontotemporal Dementia
Interventions
DRUG

DNL593

Ascending single doses (for healthy participants) and multiple doses (for participants with FTD)

DRUG

Placebo

Ascending single doses (for healthy participants) and multiple doses (for participants with FTD)

Trial Locations (32)

8036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

19104

RECRUITING

Hospital of the University of Pennsylvania, Philadelphia

20014

RECRUITING

Hospital Universitario de Donostia, Donostia / San Sebastian

21218

RECRUITING

John Hopkins University, Baltimore

28046

WITHDRAWN

Hospital Universitario La Paz, Madrid

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

94143

RECRUITING

University of California San Francisco, San Francisco

Unknown

RECRUITING

University of Antwerp, Antwerp

RECRUITING

UZ Leuven, Leuven

RECRUITING

L2IP - Instituto de Pesquisas Clinicas LTDA, Brasília

WITHDRAWN

Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre

RECRUITING

Faculdade de Medicina Da Universidade de São Paulo, São Paulo

RECRUITING

Hospital Universitario San Ignacio, Bogotá

RECRUITING

Grupo de Neurosicencias de la Universidad de Antioquia, Medellín

NOT_YET_RECRUITING

Fakultni nemocnice v Motole, Prague

RECRUITING

CHU de Nantes, Nantes

RECRUITING

CHU Rouen, Rouen

RECRUITING

CHU Toulouse, Toulouse

RECRUITING

ASST degli Spedali Civili di Brescia, Brescia

RECRUITING

Azienda Ospedaliera Universitaria Careggi, Florence

RECRUITING

IRCCS Istituto Auxologico Italiano, Milan

RECRUITING

Azienda Ospedaliera Cardinale G Panico, Tricase

RECRUITING

Erasmus University Medical Center, Rotterdam

RECRUITING

Hospital de Braga, Braga

WITHDRAWN

Hospital Pedro Hispano, Matosinhos Municipality

RECRUITING

Campus Neurológico Sénior, Torres Vedras

WITHDRAWN

University Clinical Center Nis, Niš

WITHDRAWN

Hacettepe University, Ankara

RECRUITING

Istanbul University Istanbul Medical Faculty, Istanbul

WITHDRAWN

Dokuz Eylul University Medical Faculty, Izmir

RECRUITING

Ondokuz Mayis University Hospital, Samsun

CF48 4DR

COMPLETED

Simbec Orion, Merthyr Tydfil

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Takeda

INDUSTRY

lead

Denali Therapeutics Inc.

INDUSTRY