Impact of Chest Wall Mechanics on Lung and Cardiovascular Function During Delayed Sternal Closure

NACompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

August 26, 2022

Primary Completion Date

October 26, 2023

Study Completion Date

January 8, 2024

Conditions
Palliation of Congenital Heart DiseasesCardiopulmonary BypassChest Wall MechanicsNeonatal Delayed Sternal Closure
Interventions
OTHER

Esophageal manometry catheter at various PEEP levels and tidal volumes

Participants will undergo placement of an esophageal manometry catheter before planned sternal closure. This catheter will be used to measure esophageal pressure which is a surrogate for pleural (intrathoracic) pressure. Esophageal pressure will then be used to estimate changes in respiratory system mechanics and hemodynamics following sternal closure and across different levels of positive end-expiratory pressure (PEEP) and tidal volumes.

Trial Locations (1)

Unknown

The Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

Children's Hospital Los Angeles

OTHER

lead

The Hospital for Sick Children

OTHER