A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

PHASE3RecruitingINTERVENTIONAL
Enrollment

662

Participants

Timeline

Start Date

July 22, 2022

Primary Completion Date

June 10, 2025

Study Completion Date

January 31, 2028

Conditions
Chronic Lymphocytic LeukemiaLeukemia, LymphocyticLeukemia, B-cellSmall Lymphocytic Lymphoma
Interventions
DRUG

Pirtobrutinib

Administered orally.

DRUG

Ibrutinib

Administered orally.

Trial Locations (148)

112

ACTIVE_NOT_RECRUITING

Koo Foundation Sun Yan-Sen Cancer Center, Taipei

704

ACTIVE_NOT_RECRUITING

National Cheng-Kung Uni. Hosp., Tainan City

710

ACTIVE_NOT_RECRUITING

Chang Bing Show Chwan Memorial Hospital, Changhua

1140

ACTIVE_NOT_RECRUITING

Hanusch Krankenhaus, Vienna

2025

ACTIVE_NOT_RECRUITING

Middlemore Clinical Trials, Papatoetoe

3000

ACTIVE_NOT_RECRUITING

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares, Santa Fe

ACTIVE_NOT_RECRUITING

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven

3021

ACTIVE_NOT_RECRUITING

Western Health, Sunshine Hospital, St Albans

3204

ACTIVE_NOT_RECRUITING

Waikato Hospital, Hamilton

4004

ACTIVE_NOT_RECRUITING

Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum, Debrecen

6005

ACTIVE_NOT_RECRUITING

The Perth Blood Institute, West Perth

6009

ACTIVE_NOT_RECRUITING

One Clinical Research, Nedlands

6242

ACTIVE_NOT_RECRUITING

Momentum Clinical Research, Newtown

6500

ACTIVE_NOT_RECRUITING

Gazi University Faculty of Medicine, Ankara

7600

ACTIVE_NOT_RECRUITING

Hospital Privado De Comunidad, Mar del Plata

8035

ACTIVE_NOT_RECRUITING

Hospital Universitari Vall d'Hebron, Barcelona

9016

ACTIVE_NOT_RECRUITING

Dunedin Hospital, Dunedin

9700

ACTIVE_NOT_RECRUITING

Markusovszky Egyetemi Oktatokorhaz, Szombathely

10034

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Kralovske Vinohrady, Prague

10126

RECRUITING

A.O.U. Citta' della Salute e della Scienza di Torino, Torino

12808

ACTIVE_NOT_RECRUITING

Vseobecna fakultni nemocnice v Praze, Prague

15100

ACTIVE_NOT_RECRUITING

Azienda Ospedaliera Nazionale Santi Antonio e Biagio e Cesare Arrigo, Alessandria

17007

RECRUITING

Institut Català d'Oncologia de Girona (ICO Girona), Girona

17403

ACTIVE_NOT_RECRUITING

Cancer Care Associates of York, York

20132

ACTIVE_NOT_RECRUITING

IRCCS Ospedale San Raffaele, Milan

20141

ACTIVE_NOT_RECRUITING

Istituto Europeo di Oncologia, Milan

20817

RECRUITING

American Oncology Partners of Maryland, PA, Bethesda

21500

ACTIVE_NOT_RECRUITING

KO-MED Centra Kliniczne, Biała Podlaska

23230

RECRUITING

Virginia Cancer Institute, Richmond

28031

ACTIVE_NOT_RECRUITING

Hospital Universitario Infanta Leonor-INTERNAL MED, Madrid

28034

ACTIVE_NOT_RECRUITING

Hospital Universitario Ramón y Cajal, Madrid

28222

ACTIVE_NOT_RECRUITING

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda

29600

ACTIVE_NOT_RECRUITING

Hospital Costa Del Sol, Marbella

29605

ACTIVE_NOT_RECRUITING

Prisma Health Cancer Institute, Greenville

31008

ACTIVE_NOT_RECRUITING

Clinica Universitaria De Navarra, Pamplona

ACTIVE_NOT_RECRUITING

Hospital De Navarra, Pamplona

32086

ACTIVE_NOT_RECRUITING

Cancer Specialists of North Florida -St Augustine, Saint Augustine

33401

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists East, West Palm Beach

34365

ACTIVE_NOT_RECRUITING

American Hospital, Istanbul

34457

COMPLETED

Acıbadem Maslak Hastanesi, Istanbul

34732

ACTIVE_NOT_RECRUITING

Istanbul University Istanbul Medicine Faculty, Faith

35010

RECRUITING

Hospital De Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria

35033

ACTIVE_NOT_RECRUITING

Hôpital de Pontchaillou, Rennes

35040

ACTIVE_NOT_RECRUITING

Ege Üniversitesi, Bornova

35100

ACTIVE_NOT_RECRUITING

9 Eylul University Hospital, Balçova

37044

ACTIVE_NOT_RECRUITING

CHRU De Tours, Tours

37203

ACTIVE_NOT_RECRUITING

Sarah Cannon Research Institute SCRI, Nashville

39008

ACTIVE_NOT_RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

40138

ACTIVE_NOT_RECRUITING

Policlinico Sant'Orsola Malpighi, Bologna

40519

ACTIVE_NOT_RECRUITING

Pratia Onkologia Katowice, Katowice

41009

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

42122

ACTIVE_NOT_RECRUITING

Azienda Unita Sanitaria Locale di Reggio Emilia, Reggio Emilia

44093

ACTIVE_NOT_RECRUITING

CHU de Nantes - Hotel Dieu, Nantes

44309

ACTIVE_NOT_RECRUITING

Gemeinschaftspraxis für Hämatologie und Onkologie (Gefos), Dortmund

47014

ACTIVE_NOT_RECRUITING

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

47392

RECRUITING

Inje Univ Busan Paik Hospital, Busan

59102

ACTIVE_NOT_RECRUITING

St. Vincent Frontier Cancer Center, Billings

61363

ACTIVE_NOT_RECRUITING

Chang Gung Memorial Hospital - Chiayi, Chiayi County

62500

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Brno, Brno

69495

ACTIVE_NOT_RECRUITING

Centre Hospitalier Lyon Sud, Pierre-Bénite

70112

ACTIVE_NOT_RECRUITING

Tulane Cancer Center Office of Clinical Research, New Orleans

70809

ACTIVE_NOT_RECRUITING

Hematology Oncology Clinic, Baton Rouge

72000

ACTIVE_NOT_RECRUITING

Centre Hospitalier du Mans, Le Mans

75651

ACTIVE_NOT_RECRUITING

Hopital de la Pitie Salpetriere, Paris

76038

ACTIVE_NOT_RECRUITING

Centre de Lutte Contre le Cancer - Centre Henri Becquerel Normandie Rouen, Rouen

77025

ACTIVE_NOT_RECRUITING

Kelsey Research Foundation, Houston

77339

RECRUITING

Lumi Research, Kingwood

85000

ACTIVE_NOT_RECRUITING

CHD Vendee, La Roche-sur-Yon

87042

ACTIVE_NOT_RECRUITING

Centre Hospitalier Universitaire (Limoges) (CHU DUPUYTREN 1), Limoges

89075

ACTIVE_NOT_RECRUITING

Universitätsklinikum Ulm, Ulm

90703

ACTIVE_NOT_RECRUITING

TOI Clinical Research, Cerritos

92069

ACTIVE_NOT_RECRUITING

California Cancer Associates for Research and Excellence, San Marcos

92801

RECRUITING

Pacific Cancer Medical Center, Inc, Anaheim

94305

RECRUITING

Stanford School of Medicine-Cancer Clinical Trials Office, Palo Alto

99208

ACTIVE_NOT_RECRUITING

Medical Oncology Associates, PS, Spokane

99218

ACTIVE_NOT_RECRUITING

MultiCare Health System Institute for Research and Innovation, Spokane

200032

ACTIVE_NOT_RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

230001

ACTIVE_NOT_RECRUITING

Anhui Provincial Hospital, Hefei

231200

ACTIVE_NOT_RECRUITING

The Second Hospital of Anhui Medical University, Hefei

300020

ACTIVE_NOT_RECRUITING

Blood Institute of the Chinese Academy of Medical science, Tianjin

300052

ACTIVE_NOT_RECRUITING

Tianjin Medical University General Hospital, Tianjin

310003

ACTIVE_NOT_RECRUITING

First Affiliated Hosp of College of Med, Zhejiang University, Hangzhou

310009

ACTIVE_NOT_RECRUITING

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

322000

ACTIVE_NOT_RECRUITING

The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu

330029

ACTIVE_NOT_RECRUITING

Jiangxi Provincial Cancer Hospital, Nanchang

410011

ACTIVE_NOT_RECRUITING

The Second Xiangya Hospital of Central South University, Changsha

410013

ACTIVE_NOT_RECRUITING

Hunan Cancer Hospital, Changsha

430022

ACTIVE_NOT_RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

430030

ACTIVE_NOT_RECRUITING

Wu Han Tongji Hospital, Wuhan

510060

ACTIVE_NOT_RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

510515

ACTIVE_NOT_RECRUITING

Southern Medical University Nanfang Hospital, Guangzhou

530021

ACTIVE_NOT_RECRUITING

Guangxi Medical University Affiliated Tumor Hospital, Nanning

570311

ACTIVE_NOT_RECRUITING

Hainan General Hospital, Haikou

830000

ACTIVE_NOT_RECRUITING

Affiliated Cancer Hospital of Xinjiang Medical University, Ürümqi

2520000

ACTIVE_NOT_RECRUITING

Centro de Investigaciones Clínicas Viña del Mar (CIC), Viña del Mar

4780000

ACTIVE_NOT_RECRUITING

Sociedad de Investigaciones Médicas Limitada, Temuco

6423906

ACTIVE_NOT_RECRUITING

Tel Aviv Sourasky Medical Center, Tel Aviv

7580206

ACTIVE_NOT_RECRUITING

Inmunocel, Santiago

8320000

ACTIVE_NOT_RECRUITING

CeCim Biocinetic, Santiago

9112001

ACTIVE_NOT_RECRUITING

Hadassah Medical Center, Jerusalem

14784400

ACTIVE_NOT_RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos, Barretos

80810050

ACTIVE_NOT_RECRUITING

Centro Integrado de Oncologia de Curitiba, Curitiba

81520060

ACTIVE_NOT_RECRUITING

Hospital Erasto Gaertner - Liga Paranaense de Combate ao Câncer, Curitiba

90110270

ACTIVE_NOT_RECRUITING

Centro Gaucho Integrado - Mae de Deus Center, Porto Alegre

99010090

ACTIVE_NOT_RECRUITING

Instituto do Câncer - Hospital São Vicente de Paulo, Passo Fundo

33916-2233

ACTIVE_NOT_RECRUITING

Florida Cancer Specialists, Fort Myers

C1426ANZ

ACTIVE_NOT_RECRUITING

Alexander Fleming, Ciudad Autónoma de Buenos Aire

B-9100

ACTIVE_NOT_RECRUITING

VITAZ, Sint-Niklaas

18618-687

ACTIVE_NOT_RECRUITING

Upeclin - Unidade de Pesquisa Clínica da Faculdade de Medicina de Botucatu - UNESP, Botucatu

13083-878

ACTIVE_NOT_RECRUITING

Hemocentro Unicamp, Campinas

85806-300

ACTIVE_NOT_RECRUITING

Hospital Uopeccan - Centro de Pesquisa Clinica, Cascavel

14051-140

ACTIVE_NOT_RECRUITING

Hospital de Clínicas de Ribeirão Preto, Ribeirão Preto

09060-650

ACTIVE_NOT_RECRUITING

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André

15090-000

ACTIVE_NOT_RECRUITING

Centro Integrado de Pesquisa Clinica, São José do Rio Preto

01321-001

ACTIVE_NOT_RECRUITING

Hospital BP, São Paulo

05403-000

ACTIVE_NOT_RECRUITING

Hospital da Clinicas da Faculdade de Medicina da USP, São Paulo

08270-120

ACTIVE_NOT_RECRUITING

Hospital Santa Marcelina, São Paulo

H3A 1A1

TERMINATED

Royal Victoria Hospital-Montreal, Montreal

G1J 1Z4

ACTIVE_NOT_RECRUITING

Hopital de L'Enfant Jesus, Québec

R3E 0V9

ACTIVE_NOT_RECRUITING

Cancer Care Manitoba, Winnipeg

500 05

ACTIVE_NOT_RECRUITING

Fakultni nemocnice Hradec Kralove, Hradec Králové

708 52

ACTIVE_NOT_RECRUITING

Fakultni Nemocnice Ostrava, Ostrava

305 99

ACTIVE_NOT_RECRUITING

Fakultni Nemocnice Plzen, Pilsen

06189

ACTIVE_NOT_RECRUITING

Centre Antoine Lacassagne, Nice

01307

ACTIVE_NOT_RECRUITING

Onkologische Gemeinschaftspraxis / BAG, Dresden

ACTIVE_NOT_RECRUITING

Universitaetsklinikum Carl Gustav Carus an der TU Dresden, Medizinische Klinik und Poliklinik 1, Dresden

860-8556

ACTIVE_NOT_RECRUITING

Kumamoto University Hospital, Kumamoto

990-9585

ACTIVE_NOT_RECRUITING

Yamagata University Hospital, Yamagata

85-168

ACTIVE_NOT_RECRUITING

Szpital Uniwersytecki nr 1 im. Antoniego Jurasza, Bydgoszcz

80-952

ACTIVE_NOT_RECRUITING

Uniwersyteckie Centrum Kliniczne, Gdansk

30-510

ACTIVE_NOT_RECRUITING

Pratia MCM Krakow, Krakow

20-081

ACTIVE_NOT_RECRUITING

Klinika Hematoonkologii i Transplantacji Szpiku,Samodzielny Publiczny Szpital Kliniczny Nr 1, Lublin

60-185

ACTIVE_NOT_RECRUITING

AIDPORT Sp. z o.o., Skórzewo

50-367

ACTIVE_NOT_RECRUITING

Uniwersytecki Szpital Kliniczny Klinika, Wroclaw

06591

ACTIVE_NOT_RECRUITING

The Catholic University of Korea-Seoul St. Mary's Hospital, Seocho-Gu

03080

ACTIVE_NOT_RECRUITING

Seoul National University Hospital, Seoul

06351

ACTIVE_NOT_RECRUITING

Samsung Medical Center, Seoul

08916

RECRUITING

Hospital Germans Trias i Pujol, Badalona

08025

ACTIVE_NOT_RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

08036

ACTIVE_NOT_RECRUITING

Hospital Clinic de Barcelona, Barcelona

08908

ACTIVE_NOT_RECRUITING

Hospital Duran i Reynals, L'Hospitalet de Llobregat

06590

ACTIVE_NOT_RECRUITING

Ankara University Medicine Hospital, Mamak

BS2 8ED

ACTIVE_NOT_RECRUITING

Bristol Haematology and Oncology Centre, Bristol

HU16 5JQ

RECRUITING

Castle Hill Hospital, Cottingham

LE1 5WW

ACTIVE_NOT_RECRUITING

HOPE Centre, Leicester

EC1A 7BE

ACTIVE_NOT_RECRUITING

St Bartholomew's Hospital, London

SA2 8QA

ACTIVE_NOT_RECRUITING

Singleton Hospital, Swansea

Sponsors
All Listed Sponsors
lead

Loxo Oncology, Inc.

INDUSTRY

NCT05254743 - A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) | Biotech Hunter | Biotech Hunter