Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE)

PHASE3CompletedINTERVENTIONAL
Enrollment

476

Participants

Timeline

Start Date

July 1, 2020

Primary Completion Date

October 29, 2024

Study Completion Date

November 21, 2024

Conditions
Intrauterine Growth RestrictionPreeclampsiaSickle Cell DiseasePregnancy Complications
Interventions
DRUG

Low-dose aspirin

Low dose aspirin (LDA) group will receive 100mg aspirin daily taken at once just before bedtime from 12 weeks gestational age or enrollment till 36 weeks gestational age.

OTHER

Placebo

Placebo group will receive one tablet of the placebo which has same shape, size, thickness and colour as the LDA daily taken at once just before bedtime from 12 weeks gestational age or enrollment till 36 weeks gestational age.

Trial Locations (16)

100254

Lagos University Teaching Hospital, Idi-Araba

101001

Lagos Island Maternity Hospital, Lagos, Lagos

Unknown

Ajeromi General Hospital, Ajegunle, Lagos State, Ajegunle

Federal Medical Centre, Ebute Metta, Lagos State, Ebute-Metta

Alimosho General Hospital, Igando, Lagos State, Igando

Lagos State University Teaching Hospital (LASUTH, Ikeja

General Hospital, Ikorodu, Lagos State, Ikorodu

General Hospital, Isolo, Lagos State, Isolo

General Hospital, Somolu, Lagos State, Somolu

Randle General Hospital, Surulere, Lagos State, Surulere

Obafemi Awolowo University Teaching Hospital OAUTH), Ife, Osun State, Ile-Ife

General Hospital, Gbagada, Lagos State, Lagos

General Hospital, Ibeju-Lekki, Lagos State, Lagos

General Hospital, Ifako Ijaiye, Lagos State, Lagos

General Hospital, Orile-Agege, Lagos State, Lagos

Mother and Child Centre, Amuwo-Odofin, Lagos, Lagos

All Listed Sponsors
lead

University of Lagos, Nigeria

OTHER

NCT05253781 - Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIPSICKLE) | Biotech Hunter | Biotech Hunter