Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft

Enrolling by invitationOBSERVATIONAL
Enrollment

760

Participants

Timeline

Start Date

January 1, 2005

Primary Completion Date

December 31, 2024

Study Completion Date

December 1, 2026

Conditions
Infective EndocarditisHeart Failure
Interventions
PROCEDURE

Cryopreserved Aortic Homograft

CAH is used for aortic root reconstruction and for repair of mitro-aortic curtain (emicommando procedure) and it is inserted as miniroot . In cases of PVE the infected prosthesis is removed with aggressive debridement of all infected and necrotic tissue. (7)The coronary ostia are prepared for reconstruction of aortic root. In complex valve endocarditis involving aortic and mitral valve a double homograft may be used.Mitro-aortic endocarditis intervalvular fibrosa is largely involved.The abscess cavity is precisely bounded and debrided. and a double homograft is used for the reconstruction (commando procedure

PROCEDURE

Stented/Non stented xenograft

The insertion of stented/non stented xenograft may be performed using separate or continuos stich with or without teflon pledget. Biological valves may be implated alone or combined with polyester or pericardial patch when reconstruction of annulus is required. In cases of aggressive lesions requiring root and /or intervalvular fibrosa reconstruction the choice of prosthetic bioroot using bioprosthetic valve is considered acceptable alternatives to CAH although it should be guided by the surgeon's experience

PROCEDURE

Mechanical prostheses

The insertion of conventional mechanical valves may be performed using separate or continuos stich with or without teflon pledget. Mechanical prostheses may be implated alone or combined with polyester or pericardial patch when reconstruction of annulus is required. In cases of aggressive lesions requiring root and /or intervalvular fibrosa reconstruction the choice of prosthetic valved conduit with a mechanical valve is considered acceptable alternatives to CAH although it should be guided by the surgeon's experience

Trial Locations (1)

93200

Francesco Nappi, Saint-Denis

All Listed Sponsors
collaborator

Campus Bio-Medico University

OTHER

collaborator

Henri Mondor University Hospital

OTHER

collaborator

Universita degli Studi di Genova

OTHER

collaborator

University of Bristol

OTHER

collaborator

Aberdeen Royal Infirmary

OTHER

lead

Centre Cardiologique du Nord

OTHER

NCT05253469 - Infective Endocarditis Surgery Using Conventional Prosthetic Valves Versus Cryopreserved Aortic Homograft | Biotech Hunter | Biotech Hunter