Comparing Capecitabine and Temozolomide in Combination to Lutetium Lu 177 Dotatate in Patients With Advanced Pancreatic Neuroendocrine Tumors

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

31

Participants

Timeline

Start Date

February 16, 2023

Primary Completion Date

March 31, 2028

Study Completion Date

October 1, 2033

Conditions
Metastatic Pancreatic Neuroendocrine TumorUnresectable Pancreatic Neuroendocrine Carcinoma
Interventions
DRUG

Lutetium Lu 177 Dotatate

Given IV

DRUG

Capecitabine

Given PO

DRUG

Temozolomide

Given PO

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (171)

10029

Mount Sinai Hospital, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

13210

State University of New York Upstate Medical University, Syracuse

15025

Jefferson Hospital, Jefferson Hills

15090

Wexford Health and Wellness Pavilion, Wexford

15146

Forbes Hospital, Monroeville

15212

Allegheny General Hospital, Pittsburgh

15224

West Penn Hospital, Pittsburgh

16544

Saint Vincent Hospital, Erie

20016

Sibley Memorial Hospital, Washington D.C.

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

38017

Baptist Memorial Hospital and Cancer Center-Collierville, Collierville

38120

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis

38671

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven

42003

Mercy Health - Paducah Cancer Center, Paducah

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43623

Toledo Clinic Cancer Centers-Toledo, Toledo

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

49221

Hickman Cancer Center, Adrian

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

Aurora Saint Luke's South Shore, Cudahy

53142

Aurora Cancer Care-Kenosha South, Kenosha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53228

Aurora Health Center - Greenfield, Greenfield

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Medical Center - Minocqua, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54729

Marshfield Clinic-Chippewa Center, Chippewa Falls

54848

Marshfield Medical Center - Ladysmith, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55905

Mayo Clinic in Rochester, Rochester

56187

Sanford Cancer Center Worthington, Worthington

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

60010

Advocate Good Shepherd Hospital, Barrington

60014

AMG Crystal Lake - Oncology, Crystal Lake

60048

AMG Libertyville - Oncology, Libertyville

Condell Memorial Hospital, Libertyville

60068

Advocate Lutheran General Hospital, Park Ridge

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

Advocate Sherman Hospital, Elgin

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60429

Advocate South Suburban Hospital, Hazel Crest

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60453

Advocate Outpatient Center - Oak Lawn, Oak Lawn

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60506

Advocate Outpatient Center - Aurora, Aurora

60515

Advocate Good Samaritan Hospital, Downers Grove

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60657

Advocate Illinois Masonic Medical Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63080

Missouri Baptist Sullivan Hospital, Sullivan

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

Missouri Baptist Medical Center, St Louis

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

68516

Cancer Partners of Nebraska, Lincoln

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

80112

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Rocky Mountain Cancer Centers - Swedish, Englewood

The Melanoma and Skin Cancer Institute, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80209

The Women's Imaging Center, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80501

Rocky Mountain Cancer Centers-Longmont, Longmont

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85054

Mayo Clinic Hospital in Arizona, Phoenix

90048

Cedars Sinai Medical Center, Los Angeles

90211

Tower Cancer Research Foundation, Beverly Hills

90505

Torrance Memorial Physician Network - Cancer Care, Torrance

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94598

BASS Medical Group - Lennon, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Bay Area Tumor Institute, Oakland

98368

Jefferson Healthcare, Port Townsend

99701

Fairbanks Memorial Hospital, Fairbanks

94553-3156

Contra Costa Regional Medical Center, Martinez

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06830

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06477

Smilow Cancer Hospital-Orange Care Center, Orange

06902

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

32224-9980

Mayo Clinic in Florida, Jacksonville

60453-2699

Advocate Christ Medical Center, Oak Lawn

02118

Boston Medical Center, Boston

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

02891

Smilow Cancer Hospital Care Center - Westerly, Westerly

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER

NCT05247905 - Comparing Capecitabine and Temozolomide in Combination to Lutetium Lu 177 Dotatate in Patients With Advanced Pancreatic Neuroendocrine Tumors | Biotech Hunter | Biotech Hunter