Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

79

Participants

Timeline

Start Date

November 21, 2022

Primary Completion Date

November 1, 2025

Study Completion Date

September 1, 2033

Conditions
Castration-Sensitive Prostate CarcinomaMetastatic Prostate CarcinomaStage IV Prostate Cancer AJCC V8Stage IVA Prostate Cancer AJCC V8Stage IVB Prostate Cancer AJCC V8
Interventions
OTHER

Pharmacotherapy Discontinuation

Stop hormonal medications (Abiraterone, Enzalutamide, Apalutamide, Leuprolide, Goserelin, Degarelix, Relugolix)

OTHER

Follow-Up

Undergo follow-up

OTHER

Questionnaire Administration

Ancillary studies

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (326)

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

Montefiore Medical Center-Weiler Hospital, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10604

Memorial Sloan Kettering Westchester, East White Plains

10940

Garnet Health Medical Center, Middletown

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

13126

Upstate Cancer Center at Oswego, Oswego

13210

State University of New York Upstate Medical University, Syracuse

13215

SUNY Upstate Medical Center-Community Campus, Syracuse

13478

Upstate Cancer Center at Verona, Verona

18017

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

Lehigh Valley Hospital-Hazleton, Hazleton

18301

Pocono Medical Center, East Stroudsburg

19107

Thomas Jefferson University Hospital, Philadelphia

19148

Jefferson Methodist Hospital, Philadelphia

24115

Sovah Health Martinsville, Martinsville

28791

Margaret R Pardee Memorial Hospital, Hendersonville

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33180

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

40004

Flaget Memorial Hospital, Bardstown

40353

Saint Joseph Mount Sterling, Mount Sterling

40504

Saint Joseph Hospital, Lexington

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43210

Ohio State University Comprehensive Cancer Center, Columbus

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43623

Toledo Clinic Cancer Centers-Toledo, Toledo

44484

Saint Joseph Warren Hospital, Warren

44501

Saint Elizabeth Youngstown Hospital, Youngstown

44512

Saint Elizabeth Boardman Hospital, Boardman

45005

Dayton Physicians LLC-Atrium, Franklin

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45331

Dayton Physicians LLC-Wayne, Greenville

Miami Valley Cancer Care and Infusion, Greenville

Wayne Hospital, Greenville

45373

Dayton Physicians LLC - Troy, Troy

Upper Valley Medical Center, Troy

45409

Dayton Blood and Cancer Center, Dayton

Miami Valley Hospital, Dayton

Greater Dayton Cancer Center, Kettering

45415

Dayton Physician LLC-Miami Valley Hospital North, Dayton

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45431

Indu and Raj Soin Medical Center, Beavercreek

45459

Dayton Physicians LLC-Miami Valley South, Centerville

Miami Valley Hospital South, Centerville

45840

Armes Family Cancer Center, Findlay

Blanchard Valley Hospital, Findlay

Orion Cancer Care, Findlay

47374

Reid Health, Richmond

48044

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

Michigan Breast Specialists-Macomb Township, Macomb

48054

Great Lakes Cancer Management Specialists-Doctors Park, East China

48088

Advanced Breast Care Center PLLC, Warren

48093

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

Macomb Hematology Oncology PC, Warren

Michigan Breast Specialists-Warren, Warren

Saint John Macomb-Oakland Hospital, Warren

48106

Saint Joseph Mercy Hospital, Ann Arbor

Huron Gastroenterology PC, Ypsilanti

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48114

Saint Joseph Mercy Brighton, Brighton

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

48116

University of Michigan - Brighton Center for Specialty Care, Brighton

48118

Saint Joseph Mercy Chelsea, Chelsea

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

48188

Saint Joseph Mercy Canton, Canton

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

48197

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48236

Ascension Saint John Hospital, Detroit

Academic Hematology Oncology Specialists, Grosse Pointe Woods

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods

48312

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights

48341

21st Century Oncology-Pontiac, Pontiac

Hope Cancer Center, Pontiac

Newland Medical Associates-Pontiac, Pontiac

Saint Joseph Mercy Oakland, Pontiac

48346

Hematology Oncology Consultants-Clarkston, Clarkston

Newland Medical Associates-Clarkston, Clarkston

48453

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

Genesee Cancer and Blood Disease Treatment Center, Flint

Genesee Hematology Oncology PC, Flint

Genesys Hurley Cancer Institute, Flint

Hurley Medical Center, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48604

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

Caro Cancer Center, Caro

48764

Ascension Saint Joseph Hospital, Tawas City

48912

University of Michigan Health - Sparrow Lansing, Lansing

49221

Hickman Cancer Center, Adrian

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50314

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50325

Medical Oncology and Hematology Associates-West Des Moines, Clive

Mercy Cancer Center-West Lakes, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51503

Alegent Health Mercy Hospital, Council Bluffs

53051

Froedtert Menomonee Falls Hospital, Menomonee Falls

53095

Froedtert West Bend Hospital/Kraemer Cancer Center, West Bend

53154

Drexel Town Square Health Center, Oak Creek

53226

Medical College of Wisconsin, Milwaukee

54017

Cancer Center of Western Wisconsin, New Richmond

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55008

Cambridge Medical Center, Cambridge

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

Fairview Northland Medical Center, Princeton

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

56073

New Ulm Medical Center, New Ulm

56187

Sanford Cancer Center Worthington, Worthington

56201

Rice Memorial Hospital, Willmar

56601

Sanford Joe Lueken Cancer Center, Bemidji

56701

Sanford Thief River Falls Medical Center, Thief River Falls

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

58103

Sanford South University Medical Center, Fargo

Southpointe-Sanford Medical Center Fargo, Fargo

58104

Sanford Medical Center Fargo, Fargo

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

Northwestern Medicine Cancer Center Delnor, Geneva

60426

Ingalls Memorial Hospital, Harvey

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

Northwestern Medicine Orland Park, Orland Park

University of Chicago Medicine-Orland Park, Orland Park

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

62002

Saint Anthony's Health, Alton

62269

Cancer Care Center of O'Fallon, O'Fallon

HSHS Saint Elizabeth's Hospital, O'Fallon

Memorial Hospital East, Shiloh

62321

Illinois CancerCare-Carthage, Carthage

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

Saint Mary's Hospital, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63110

Washington University School of Medicine, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63129

Siteman Cancer Center-South County, St Louis

63131

Missouri Baptist Medical Center, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65065

Lake Regional Hospital, Osage Beach

65109

Capital Region Southwest Campus, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68122

Alegent Health Immanuel Medical Center, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

CHI Health Saint Francis, Grand Island

68847

CHI Health Good Samaritan, Kearney

72205

CARTI Cancer Center, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

77802

Saint Joseph Regional Cancer Center, Bryan

80045

Rocky Mountain Regional VA Medical Center, Aurora

80122

Littleton Adventist Hospital, Littleton

80138

Parker Adventist Hospital, Parker

80210

Porter Adventist Hospital, Denver

80228

Saint Anthony Hospital, Lakewood

80501

Longmont United Hospital, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83642

Idaho Urologic Institute-Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

85004

Cancer Center at Saint Joseph's, Phoenix

92270

Eisenhower Medical Center, Rancho Mirage

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

94568

Epic Care-Dublin, Dublin

94597

Epic Care Cyberknife Center, Walnut Creek

94608

Bay Area Breast Surgeons Inc, Emeryville

Epic Care Partners in Cancer Care, Emeryville

94609

Bay Area Tumor Institute, Oakland

95340

Mercy UC Davis Cancer Center, Merced

95608

Mercy Cancer Center �� Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95816

Mercy Cancer Center - Sacramento, Sacramento

97814

Saint Alphonsus Medical Center-Baker City, Baker City

97914

Saint Alphonsus Medical Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98166

Highline Medical Center-Main Campus, Burien

98310

Harrison Medical Center, Bremerton

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

98499

Saint Clare Hospital, Lakewood

94553-3156

Contra Costa Regional Medical Center, Martinez

02215

Dana-Farber Cancer Institute, Boston

02035

Dana-Farber Cancer Institute at Foxborough, Foxborough

01757

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional, Milford

02190

Dana-Farber/Brigham and Women's Cancer Center at South Shore, South Weymouth

01655

UMass Memorial Medical Center - University Campus, Worcester

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08701

Monmouth Medical Center Southern Campus, Lakewood

07039

Saint Barnabas Medical Center, Livingston

07740

Monmouth Medical Center, Long Branch

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

08755

Community Medical Center, Toms River

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Alliance for Clinical Trials in Oncology

OTHER