1,800
Participants
Start Date
March 15, 2022
Primary Completion Date
October 28, 2026
Study Completion Date
September 28, 2029
Belzutifan
Three 40 mg tablets given as a single oral 120 mg dose.
Pembrolizumab
400 mg via IV infusion
Placebo
Oral tablet
Taipei Veterans General Hospital ( Site 2903), Taipei
Chang Gung Medical Foundation-Linkou Branch-Urology ( Site 2906), Taoyuan District
Taichung Veterans General Hospital ( Site 2902), Taichung
Auckland City Hospital ( Site 2003), Auckland
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1316), Budapest
MHAT Serdika-Second Department of Medical Oncology ( Site 0203), Sofia
Macquarie University-MQ Health Clinical Trials Unit ( Site 0003), Macquarie University
Blacktown Hospital ( Site 0002), Blacktown
Tamworth Hospital-North West Cancer Centre ( Site 0006), North Tamworth
Austin Health-Cancer Clinical Trials Centre ( Site 0005), Heidelberg
Complex Cancer Center Plovdiv-First Medical Oncology Department ( Site 0205), Plovdiv
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Site 0001), Brisbane
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1310), Debrecen
MBAL Uni Hospital-Department of Medical Oncology ( Site 0204), Panagyurishte
Lyell McEwin Hospital-Oncology Clinical Trials Unit ( Site 0008), Elizabeth Vale
Fiona Stanley Hospital-Medical Oncology ( Site 0004), Murdoch
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ ( Site 1319), Szeged
Ankara Bilkent Şehir Hastanesi-oncology ( Site 3206), Ankara
Somogy Megyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1311), Kaposvár
Petz Aladar Egyetemi Oktato Korhaz-Onkológiai Osztály ( Site 1321), Győr
National Taiwan University Hospital ( Site 2904), Taipei
Icahn School of Medicine at Mount Sinai ( Site 3539), New York
Azienda Sanitaria Ospedaliera S Luigi Gonzaga-SCDU Oncologia Medica ( Site 1602), Orbassano
Memorial Sloan Kettering Cancer Center ( Site 3568), New York
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 1022), Berlin
Chulalongkorn University ( Site 3005), Bangkok
Ramathibodi Hospital ( Site 3001), Bangkok
National Cancer Center-Center for Urologic Cancer ( Site 2604), Goyang-si
Hospital Pulau Pinang ( Site 1806), George Town
Faculty of Medicine Siriraj Hospital ( Site 3002), Bangkok
Monter Cancer Center ( Site 3560), Lake Success
Tri-Service General Hospital ( Site 2908), Taipei City
Helios Klinikum Berlin-Buch ( Site 1011), Berlin
Seoul National University Bundang Hospital-Urology ( Site 2602), Seongnam
INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1902), Mexico City
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran-Oncologia y Hematologia ( Site 1912), Mexico City
University of Rochester Medical Center ( Site 3528), Rochester
Institut Català d'Oncologia (ICO) - Girona ( Site 2707), Girona
MidLantic urology ( Site 3501), Bala-Cynwyd
Fox Chase Cancer Center-GU Oncology ( Site 3535), Philadelphia
Georgetown University Medical Center ( Site 3534), Washington D.C.
Ospedale San Raffaele-Oncologia Medica ( Site 1606), Milan
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1608), Milan
Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 1001), Hamburg
Turku University Hospital ( Site 0801), Turku
Johns Hopkins Hospital-Sidney Kimmel Comprehensive Cancer Center- GU Oncology ( Site 3549), Baltimore
Inova Schar Cancer Institute ( Site 3525), Fairfax
CHU Besançon-Medical oncology ( Site 0904), Besançon
Hospital Lucus Augusti-Oncology ( Site 2706), Lugo
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2710), Madrid
Hospital Clinico San Carlos-Oncology Department ( Site 2703), Madrid
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2708), Madrid
Hospital Universitario Virgen de la Victoria-Phase II-III-IV Trials ( Site 2709), Málaga
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 3515), Marietta
University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 3517), Miami
Tampereen yliopistollinen sairaala ( Site 0805), Tampere
Moffitt Cancer Center ( Site 3540), Tampa
Istanbul Universitesi Cerrahpasa-Internal Diseases ( Site 3204), Istanbul- Fatih
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 3201), Istanbul
Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou ( Site 0908), Rennes
Ege University Medicine of Faculty-Medical Oncology ( Site 3202), Izmir
ROC37 ( Site 0910), Chambray-lès-Tours
Urology Associates ( Site 3512), Nashville
The West Clinic, PLLC dba West Cancer Center ( Site 3522), Germantown
IRCCS - AOU di Bologna-Oncologia Medica Ardizzoni ( Site 1605), Bologna
Universitaetsklinikum Duesseldorf ( Site 1017), Düsseldorf
China Medical University Hospital-Department of Urology ( Site 2907), Taichung
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 3507), Columbus
Terapias Integrales del Riñon SA de CV ( Site 1910), Guadalajara
Hospital Civil Fray Antonio Alcalde-Oncology ( Site 1906), Guadalajara
Universitaetsklinikum Essen ( Site 1004), Essen
Fundación Instituto Valenciano de Oncología ( Site 2705), Valencia
Parkview Research Center at Parkview Regional Medical Center ( Site 3526), Fort Wayne
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1603), Meldola
Universitätsklinikum Münster - Albert Schweitzer Campus ( Site 1005), Münster
Cancer and Hematology Centers of Western Michigan ( Site 3502), Grand Rapids
Centre Hospitalier Universitaire d'Angers-Urology ( Site 0901), Angers
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1601), Florence
Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu ( Site 2309), Wrocław
Universitätsklinikum Aachen ( Site 1024), Aachen
Azienda USL 8 di Arezzo-Medical Oncology ( Site 1610), Arezzo
Universitätsklinikum Bonn ( Site 1006), Bonn
Sanford Cancer Center ( Site 3551), Sioux Falls
University Malaya Medical Centre ( Site 1804), Lembah Pantai
St. Vincent Frontier Cancer Center-Research ( Site 3506), Billings
Washington University-Internal Medicine/Oncology ( Site 3531), St Louis
Filios Alta Medicina ( Site 1903), Monterrey
iCan Oncology Center Centro Medico AVE ( Site 1901), Monterrey
Universitaetsklinikum des Saarlandes-Klinik fuer Urologie und Kinderurologies ( Site 1020), Homburg
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0903), Strasbourg
Centro de Investigacion Clinica de Oaxaca ( Site 1904), Oaxaca City
Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 3550), Omaha
A.O.U.C. Policlinico di Bari ( Site 1607), Bari
Kuopion Yliopistollinen Sairaala-Syöpäkeskus ( Site 0804), Kuopio
Universitaetsklinikum Tuebingen ( Site 1002), Tübingen
Oncocenter ( Site 1909), Puebla City
Hôpital Saint-Louis ( Site 0905), Paris
Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0906), Paris
UT Southwestern Medical Center ( Site 3529), Dallas
Hospital H+ Queretaro-Cuidados Oncológicos ( Site 1905), Querétaro City
BRCR Global Mexico - Queretaro-SMIQ ( Site 1907), Querétaro City
University of Texas MD Anderson Cancer Center-Urology ( Site 3569), Houston
Hegau-Bodensee-Klinikum Singen ( Site 1016), Singen
Centro de Oncología Personalizada ( Site 1911), Culiacán
University of Colorado Anschutz Medical Campus ( Site 3514), Aurora
Kaohsiung Veterans General Hospital ( Site 2901), Kaohsiung City
Intermountain Health St. Mary's Regional Hospital ( Site 3562), Grand Junction
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 1003), Munich
Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 2905), Kaohsiung Niao Sung Dist
Mayo Clinic in Arizona - Phoenix ( Site 3554), Phoenix
UCLA Hematology/Oncology - Westwood (Building 200 Suite 140)-Department of Urology/Institute of Uro ( Site 3520), Los Angeles
Songklanagarind hospital ( Site 3004), Hat Yai
Oulun yliopistollinen sairaala ( Site 0802), Oulu
City of Hope Comprehensive Cancer Center ( Site 3567), Duarte
Moores Cancer Center-Clinical Trials Office- Genitourinary ( Site 3516), La Jolla
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 3518), Orange
Sarawak General Hospital-Radiotherapy Unit ( Site 1805), Kuching
Stanford Cancer Center ( Site 3523), Palo Alto
Gustave Roussy ( Site 0907), Villejuif
Seattle Cancer Care Alliance-Renal/Melanoma/MCC ( Site 3524), Seattle
Cancer Hospital Chinese Academy of Medical Science-Urinary Surgery ( Site 0435), Beijing
Beijing Cancer hospital-Urinary Surgery ( Site 0406), Beijing
First Medical Center of Chinese PLA General Hospital ( Site 0415), Beijing
Peking University First Hospital-Urology ( Site 0407), Beijing
Administradora Country S.A. - Clinica del Country ( Site 0504), Bogotá
National University Hospital ( Site 3602), Singapore
National Cancer Centre Singapore ( Site 3601), Singapore
Fudan University Shanghai Cancer Center-Urology department ( Site 0401), Shanghai
Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 0418), Shanghai
Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 0505), Valledupar
Huadong Hospital Affiliated to Fudan University ( Site 0405), Shanghai
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2401), Craiova
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 0424), Nanjing
Second Affiliated hospital of Anhui Medical University-Urology ( Site 0416), Hefei
IMAT S.A.S ( Site 0501), Montería
Afflilated Hospital of Bengbu Medical College-Urology Surgery ( Site 0438), Bengbu
Tianjin Medical University Cancer Institute and Hospital ( Site 0422), Tianjin
Cabinet Medical Oncomed ( Site 2403), Timișoara
The First Affiliated Hospital, Zhejiang University ( Site 0428), Hangzhou
Zhejiang Provincial People's Hospital-Urology ( Site 0426), Hangzhou
Ningbo First Hospital-Urology ( Site 0433), Ningbo
The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0425), Wenzhou
The Second Affiliated Hospital of Nanchang University ( Site 0443), Nanchang
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 0432), Nanchang
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0445), Fuzhou
Cardiomed SRL Cluj-Napoca ( Site 2406), Cluj-Napoca
Chongqing University Cancer Hospital ( Site 0414), Chongqing
Army Medical Center of People's Liberation Army ( Site 0439), Chongqing
Amethyst Radiotherapy Center-Oncologie Medicala ( Site 2405), Florești
Hunan Cancer Hospital ( Site 0421), Changsha
Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 0423), Wuhan
Wuhan Union Hospital ( Site 0430), Wuhan
Hubei Cancer Hospital-Urinary surgery ( Site 0419), Wuhan
Henan Cancer Hospital-Urology ( Site 0441), Zhengzhou
The First Affiliated Hospital of Guangzhou Medical University ( Site 0403), Guangzhou
Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Urology Surgery ( Site 0402), Guangzhou
SUN YAT-SEN UNIVERSITY CANCER CENTRE-Urology Surgery ( Site 0417), Guangzhou
West China Hospital of Sichuan University-Urology Surgery ( Site 0410), Chengdu
The First Affiliated Hospital of Xi'an Jiaotong University ( Site 0431), Xi'an
Bradford Hill Norte ( Site 0303), Antofagasta
ONCOCENTRO APYS-ACEREY ( Site 0301), Viña del Mar
Rambam Health Care Campus-Oncology ( Site 1502), Haifa
James Lind Centro de Investigacion del Cancer ( Site 0307), Temuco
Rabin Medical Center-Oncology ( Site 1503), Petah Tikva
Oncocentro Valdivia ( Site 0312), Valdivia
Sheba Medical Center-ONCOLOGY ( Site 1504), Ramat Gan
Clínica Puerto Montt ( Site 0309), Port Montt
Sourasky Medical Center-Oncology ( Site 1501), Tel Aviv
FALP-UIDO ( Site 0302), Santiago
Oncovida ( Site 0306), Santiago
Soroka Medical Center ( Site 1505), Beersheba
Bradfordhill ( Site 0305), Santiago
Hadassah Medical Center-Oncology ( Site 1506), Jerusalem
Hospital de Clínicas de Ribeirão Preto ( Site 0112), Ribeirão Preto
Centro Avançado de Tratamento Oncológico- CENANTRON-Clinical Research ( Site 0105), Belo Horizonte
Massachusetts General Hospital ( Site 3571), Boston
Beth Israel Deaconess Medical Center-Cancer Clinical Trials Office ( Site 3572), Boston
Dana-Farber Cancer Institute-GU ( Site 3505), Boston
Englewood Hospital and Medical Center ( Site 3557), Englewood
Rutgers Cancer Institute of New Jersey ( Site 3541), New Brunswick
Hospital São Carlos-Oncocentro Ce ( Site 0104), Fortaleza
Instituto do Câncer e Transplante de Curitiba ( Site 0102), Curitiba
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 0103), Natal
Hospital Nossa Senhora da Conceição-Centro Integrado de Pesquisa em Oncologia ( Site 0101), Porto Alegre
BP - A Beneficencia Portuguesa de São Paulo ( Site 0111), São Paulo
Arthur J.E. Child Comprehensive Cancer Centre ( Site 3706), Calgary
BC Cancer Vancouver-Clinical Trials Unit ( Site 3707), Vancouver
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 3710), Hamilton
Victoria Hospital & Children's Hospital - London Health Scie-London Regional Cancer Program ( Site 3705), London
Princess Margaret Cancer Centre ( Site 3703), Toronto
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 3708), Montreal
McGill University Health Centre ( Site 3709), Montreal
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 3701), Québec
Clinica de la Costa S.A.S. ( Site 0506), Barranquilla
Fakultni Nemocnice u sv. Anny v Brne-Onkologicko-chirurgicke oddeleni ( Site 0603), Brno
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0605), Brno
Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0606), Ostrava
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0601), Olomouc
Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0602), Prague
Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0607), Prague
Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 0604), Hradec Králové
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0803), Helsinki
CENTRE LEON BERARD-Medical oncology ( Site 0902), Lyon
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Urologie ( Site 1021), Dresden
Krankenhaus Martha-Maria Halle-Dölau-Klinik für Urologie, Kinderurologie und urologische Onkologie ( Site 1008), Halle
SRH Wald-Klinikum Gera ( Site 1015), Gera
Universitätsklinikum Jena ( Site 1007), Jena
Alexandra Hospital-ONCOLOGY DEPT. ( Site 1102), Athens
Metropolitan Hospital-2nd Oncology Dept ( Site 1104), Athens
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1101), Chaïdári
Euromedica General Clinic Thessaloniki-Oncology Unit ( Site 1103), Thessaloniki
European Interbalkan Medical Center-Oncology Department ( Site 1105), Thessaloniki
St. Vincent's University Hospital ( Site 1401), Dublin
Tallaght University Hospital ( Site 1402), Dublin
Cork University Hospital ( Site 1404), Cork
Beaumont Hospital, Dublin-Cancer Clinical Trials & Research Unit ( Site 1403), Dublin
Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1604), Rome
Azienda Ospedaliera Santa Maria Terni-SC Oncologia ( Site 1609), Terni
Fujita Health University Hospital ( Site 1709), Toyoake
National Cancer Center Hospital East ( Site 1704), Kashiwa
Toho University Sakura Medical Center ( Site 1718), Sakura
Ehime University Hospital ( Site 1714), Tōon
Sapporo Medical University Hospital ( Site 1702), Sapporo
Hokkaido University Hospital ( Site 1701), Sapporo
Kanagawa Cancer Center ( Site 1703), Yokohama
Nara Medical University Hospital ( Site 1712), Kashihara
Bell Land General Hospital ( Site 1710), Sakai
The University of Osaka Hospital ( Site 1711), Suita
Hamamatsu University Hospital ( Site 1708), Hamamatsu
Toranomon Hospital ( Site 1706), Minato-ku
Toyama University Hospital ( Site 1713), Toyoma
Kyushu University Hospital ( Site 1715), Fukuoka
Kagoshima University Hospital ( Site 1719), Kagoshima
Kumamoto University Hospital ( Site 1716), Kumamoto
Okayama University Hospital ( Site 1720), Okayama
Nippon Medical School Hospital ( Site 1705), Tokyo
Tokyo Women's Medical University Adachi Medical Center ( Site 1717), Tokyo
Keio University Hospital ( Site 1707), Tokyo
Wakayama Medical University Hospital ( Site 1721), Wakayama
BRCR Global Mexico - Guadalajara-Research ( Site 1908), Guadalajara
Ziekenhuis Rijnstate-Rijnstate Centrum Oncologisch Onderzoek ( Site 3113), Arnhem
Radboudumc ( Site 3120), Nijmegen
Maastricht UMC+ ( Site 3104), Maastricht
Amphia Ziekenhuis, locatie Breda Molengracht ( Site 3103), Breda
Maxima Medisch Centrum, locatie Eindhoven ( Site 3116), Eindhoven
Amsterdam UMC, locatie AMC ( Site 3105), Amsterdam
Tergooiziekenhuizen, locatie Hilversum ( Site 3102), Hilversum
Spaarne Gasthuis - Hoofddorp-Oncology ( Site 3107), Hoofddorp
Isala, locatie Zwolle-Oncology ( Site 3111), Zwolle
Haaglanden MC - locatie Antoniushove ( Site 3117), Leidschendam
Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 3101), Schiedam
Haga Ziekenhuis locatie Leyweg-Oncology ( Site 3108), The Hague
University Medical Center Groningen ( Site 3121), Groningen
St. Antonius Ziekenhuis, locatie Utrecht-Interne geneeskunde ( Site 3112), Utrecht
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 3106), Utrecht
Przychodnia Lekarska KOMED ( Site 2304), Konin
Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu M-chemotherapy department ( Site 2312), Poznan
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 2307), Bydgoszcz
MICS Centrum Medyczne Torun ( Site 2305), Torun
Szpital Wojewódzki im. Świętego Lukasza SP ZOZ w Tarnowie ( Site 2311), Tarnów
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2313), Siedlce
Luxmed Onkologia sp. z o. o. ( Site 2303), Warsaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2301), Warsaw
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 2306), Przemyśl
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 2302), Koszalin
Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 2315), Szczecin
Radiology Therapeutic Center-Oncology ( Site 2404), Otopeni
MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 2407), Bucharest
Asan Medical Center-Oncology ( Site 2601), Songpagu
Samsung Medical Center ( Site 2603), Seoul
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2702), Barcelona
Karolinska Universitetssjukhuset Solna ( Site 2802), Stockholm
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 2803), Uppsala
Sahlgrenska Universitetssjukhuset ( Site 2801), Gothenburg
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 3208), Adana
Ankara Gülhane Eitim ve Aratrma Hastanesi-Oncology ( Site 3207), Ankara
Ankara University Hospital Cebeci ( Site 3209), Ankara
Hacettepe Universitesi-oncology hospital ( Site 3203), Ankara
Royal Free Hospital ( Site 3304), London
The Christie NHS Foundation Trust ( Site 3301), Manchester
City Hospital, Nottingham University Hospitals ( Site 3303), Nottingham
Beatson West of Scotland Cancer Centre-Clinical Trials Unit ( Site 3305), Glasgow
Charing Cross Hospital ( Site 3302), London
St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3307), London
Singleton Hospital ( Site 3306), Swansea
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INDUSTRY