Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy

NACompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

April 26, 2017

Primary Completion Date

May 1, 2021

Study Completion Date

November 1, 2021

Conditions
Epilepsy
Interventions
DRUG

Rapid withdrawal of antiepileptic

"Reduction by about 20 % of initial dosage every 15 days until complete discontinuation (total withdrawal time: 60 days).~Drugs: carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid, zonisamide"

DRUG

Slow withdrawal of antiepileptic

"Slow withdrawal: reduction by about 20 % of initial dosage every 40 days, until complete discontinuation (total withdrawal time: 160 days).~Drugs: carbamazepine, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, topiramate, valproic acid, zonisamide"

Trial Locations (1)

89100

Regional Epilepsy Center, Presidio Riuniti, Magna Græcia University of Catanzaro, Reggio Calabria

All Listed Sponsors
collaborator

Ministry of Health, Italy

OTHER_GOV

lead

University Magna Graecia

OTHER

NCT05236166 - Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy | Biotech Hunter | Biotech Hunter