460
Participants
Start Date
March 24, 2022
Primary Completion Date
June 4, 2024
Study Completion Date
June 7, 2027
Pembrolizumab/Vibostolimab Co-Formulation
Pembrolizumab 200 mg plus vibostolimab 200 mg fixed dose coformulation administered via IV infusion Q3W on Day 1 of each cycle until discontinuation criteria are met.
Saline placebo
Saline solution administered via IV infusion on Cycle 1 (and Q3W as needed beyond Cycle 1)
Etoposide
Etoposide 100 mg/m\^2 administered via IV infusion Q3W on Days 1 2, 3 of each cycle for up to 4 cycles
Cisplatin
Cisplatin 75 mg/m\^2 administered via IV infusion Q3W on Day 1 of each cycle for up to 4 cycles.
Atezolizumab
Atezolizumab 1200 mg administered via IV infusion Q3W on Day 1 of each cycle until discontinuation criteria are met.
Carboplatin
Carboplatin AUC 5 mg/mL/min administered via IV infusion Q3W on Day 1 of each cycle for up to 4 cycles.
Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0502), Vienna
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0501), Vienna
Hospital Provincial del Centenario ( Site 0205), Rosario
Reformatus Pulmonologiai Centrum-Onkopulmonologiai Jarobeteg Centrum ( Site 1101), Törökbálint
Calvary Mater Newcastle ( Site 2703), Waratah
Nepean Hospital ( Site 2700), Kingswood
Western Health-Sunshine & Footscray Hospitals-Cancer Services-Cancer Research ( Site 2701), Melbourne
Frankston Hospital-Oncology and Haematology ( Site 2702), Frankston
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0505), Linz
Kepler Universitätsklinikum ( Site 0507), Linz
Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1105), Kecskemét
Somogy Megyei Kaposi Mór Oktató Kórház-Pulmonologiai Osztaly ( Site 1104), Kaposvár
Medizinische Universität Graz ( Site 0504), Graz
Petz Aladar Egyetemi Oktato Korhaz-Pulmonológia (Dr. Szalai Zsuzsanna) ( Site 1102), Győr
Sotiria Thoracic Diseases Hospital of Athens ( Site 1003), Athens
Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0805), Marseille
Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0005), Lancaster
Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1403), Rozzano
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1401), Milan
Turku University Hospital-The Department of Pulmonary Medicine ( Site 0701), Turku
University of Virginia Cancer Center ( Site 0019), Charlottesville
LungenClinic Grosshansdorf-Onkologie ( Site 0903), Großhansdorf
Blue Ridge Cancer Care ( Site 0015), Blacksburg
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2102), Madrid
H.R.U Málaga - Hospital General-Oncology ( Site 2104), Málaga
Medizinische Hochschule Hannover-Department of Pneumology ( Site 0901), Hanover
CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 0800), Toulouse
Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0014), Boca Raton
Medipol University Medical Faculty-oncology ( Site 2400), Istanbul
Lungenfachklinik Immenhausen-Thoracic Oncology ( Site 0907), Immenhausen
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2401), Istanbul
Chungnam national university hospital-Department of Internal Medicine ( Site 2802), Daejeon
Ege University Medicine of Faculty-Chest Diseases Department ( Site 2402), Bornova
I.E.U. Medical Point Hastanesi-Oncology ( Site 2408), Izmir
Infirmary Cancer Care ( Site 0022), Mobile
Hattiesburg Clinic Hematology/Oncology ( Site 0003), Hattiesburg
Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 2103), Seville
Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2801), Deagu
Hospital Civil Fray Antonio Alcalde-Oncology ( Site 0407), Guadalajara
Actualidad Basada en la Investigación del Cáncer-Lung Cancer ( Site 0403), Guadalajara
Fort Wayne Medical Oncology and Hematology ( Site 0013), Fort Wayne
Cancer and Hematology Centers of Western Michigan ( Site 0001), Grand Rapids
Chonnam National University Hwasun Hospital-Pulmonology ( Site 2800), Hwasun
iCan Oncology Center Centro Medico AVE ( Site 0406), Monterrey
Vaasan Keskussairaala-Department of Clinical Oncology ( Site 0700), Vaasa
Centro de Investigacion Clinica de Oaxaca ( Site 0410), Oaxaca City
Thoraxklinik-Heidelberg gGmbH-Studienzentrum Thoraxonkologie ( Site 0905), Heidelberg
University General Hospital of Heraklion ( Site 1004), Heraklion
Azienda Ospedaliera Dei Colli-U.O.C Pneumologia Oncologica DH PNL ONC ( Site 1402), Naples
Centre Hospitalier Universitaire de Limoges - Hôpital Dupuyt-Unité d'oncologie thoracique et cutané ( Site 0803), Limoges
Los Angeles Hematology Oncology Medical Group ( Site 0006), Los Angeles
VA West Los Angeles Medical Center ( Site 0004), Los Angeles
Oulun yliopistollinen sairaala-Oncology and Hematology ( Site 0702), Oulu
Klaipeda University Hospital-Oncology chemotherapy ( Site 1502), Klaipėda
Beijing Cancer hospital-Thoracic Cancer Department A ( Site 2901), Beijing
Beijing Peking Union Medical College Hospital ( Site 2921), Beijing
Jilin Cancer Hospital-GCP office ( Site 2909), Changchun
The First Hospital of Jilin University ( Site 2914), Changchun
Harbin Medical University Cancer Hospital-oncology of department ( Site 2920), Harbin
Shanghai Chest Hospital-Oncology department ( Site 2900), Shanghai
Fudan University Shanghai Cancer Center ( Site 2908), Shanghai
Centrul de Oncologie Oncolab-Medical Oncology ( Site 1904), Craiova
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 1901), Craiova
The First Affiliated Hospital of Soochow University ( Site 2913), Suzhou
Anhui Cancer Hospital ( Site 2915), Hefei
Cabinet Medical Oncomed ( Site 1902), Timișoara
Sir Run Run Shaw Hospital-Medical Oncology ( Site 2906), Hangzhou
Zhejiang Cancer Hospital-Oncology ( Site 2919), Hangzhou
Fujian Provincial Cancer Hospital-oncology department ( Site 2904), Fuzhou
Cardiomed SRL Cluj-Napoca ( Site 1900), Cluj-Napoca
Hunan Cancer Hospital ( Site 2907), Changsha
Union Hospital Tongji Medical College Huazhong University of Science and Technology-Medical Oncology ( Site 2912), Wuhan
Hubei Cancer Hospital ( Site 2922), Wuhan
Henan Cancer Hospital ( Site 2916), Zhengzhou
Sichuan Cancer hospital. ( Site 2923), Chengdu
West China Hospital Sichuan University ( Site 2903), Chengdu
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 2910), Xi'an
Rambam Health Care Campus-Oncology ( Site 1301), Haifa
Sheba Medical Center-ONCOLOGY ( Site 1302), Ramat Gan
Shaare Zedek Medical Center-Oncology ( Site 1300), Jerusalem
Dana-Farber Cancer Institute ( Site 0018), Boston
Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 0203), Ciudad Autonoma de Buenos Aires
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201), Mar del Plata
Centro de Educación Médica e Investigaciones Clínicas (CEMIC)-Medical Oncology ( Site 0200), Buenos Aires
Sanatorio Parque ( Site 0202), Rosario
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0106), Kingston
Lakeridge Health ( Site 0102), Oshawa
SRH Wald-Klinikum Gera-Lungenkrebszentrum ( Site 0900), Gera
Errikos Dunant Hospital Center-Second Department of Oncology and Clinical Trials Unit ( Site 1002), Athens
Metropolitan Hospital ( Site 1001), Athens
European Interbalkan Medical Center ( Site 1000), Thessaloniki
St. James's Hospital ( Site 1200), Dublin
Beaumont Hospital, Dublin-Cancer Clinical Trials & Research Unit ( Site 1201), Dublin
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1400), Rome
Aichi Cancer Center ( Site 3016), Nagoya
National Cancer Center Hospital East ( Site 3002), Kashiwa
National Hospital Organization Shikoku Cancer Center ( Site 3012), Matsuyama
Kurume University Hospital ( Site 3014), Kurume
National Hospital Organization Hokkaido Cancer Center ( Site 3015), Sapporo
Kanazawa University Hospital ( Site 3006), Kanazawa
Kanagawa Cancer Center ( Site 3004), Yokohama
Sendai Kousei Hospital ( Site 3001), Sendai
Niigata Cancer Center Hospital ( Site 3005), Niigata
Kansai Medical University Hospital ( Site 3009), Hirakata
Shizuoka Cancer Center ( Site 3007), Nakatogari
Cancer Institute Hospital of JFCR ( Site 3003), Koto
National Hospital Organization Kyushu Medical Center ( Site 3013), Fukuoka
Okayama University Hospital ( Site 3011), Okayama
National Cancer Institute-Department of Thoracic Surgery and Oncology ( Site 1501), Vilnius
Hospital of Lithuanian University of Health Sciences Kauno klinikos-Pulmonology ( Site 1500), Kaunas
Arké SMO S.A. de C.V. ( Site 0401), Mexico City
Ziekenhuis Rijnstate ( Site 1606), Arnhem
Maastricht UMC+-Pulmonary disease ( Site 1602), Maastricht
Jeroen Bosch Hospital-Pulmonology ( Site 1605), 's-Hertogenbosch
Isala, locatie Zwolle-Poli Longziekten ( Site 1612), Zwolle
Medische Centrum Leeuwarden ( Site 1619), Leeuwarden
Erasmus Medisch Centrum ( Site 1621), Rotterdam
Martini Ziekenhuis ( Site 1618), Groningen
Przychodnia Lekarska KOMED ( Site 1701), Konin
Med-Polonia Sp. z o. o. ( Site 1710), Poznan
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1709), Siedlce
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1700), Warsaw
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1703), Przemyśl
Szpital Specjalistyczny w Prabutach Spolka z o.o. ( Site 1706), Prabuty
Centrum Pulmonologii i Torakochirurgii w Bystrej ( Site 1707), Bystra
Champalimaud Foundation ( Site 1812), Lisbon
Hospital CUF Descobertas ( Site 1815), Lisbon
Centro Hospitalar do Porto - Hospital de Santo António ( Site 1813), Porto
Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 1810), Porto
MedEuropa Bucuresti - Centru de Radioterapie-Oncology ( Site 1905), Bucharest
Centrul medical Focus ( Site 1903), Bucharest
Korea University Guro Hospital-Internal Medicine ( Site 2803), Seoul
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2100), Barcelona
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 2407), Adana
Hacettepe Universitesi-oncology hospital ( Site 2409), Ankara
Memorial Ankara Hastanesi-Medical Oncology ( Site 2406), Ankara
Ankara Bilkent City Hospital ( Site 2403), Ankara
The Christie-Clinical Research Facility ( Site 2607), Manchester
Mount Vernon Hospital ( Site 2602), Northwood
Heartlands Hospital-Oncology Research ( Site 2604), Birmingham
Merck Sharp & Dohme LLC
INDUSTRY